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Amantadine

Written by \"\"Aimee AveyardMedically reviewed by \"\"Leila Khurshid, Pharm.D.

Published on · Updated on

Amantadine is a medication that was originally developed as an influenza drug and is now primarily used to counteract the side effects of medication for Parkinson’s disease. It can also be used to treat certain mental health conditions, including obsessive-compulsive disorder, treatment-resistant depression and others, such as attention deficit hyperactivity disorder and autism.

\"A

Key takeaways

  • Amantadine is used for Parkinson-related symptoms and may be prescribed for selected mental health conditions.
  • Side effects can include confusion, low blood pressure, hallucinations, and compulsive behaviors.
  • Abrupt discontinuation can cause serious adverse effects, so treatment changes require medical guidance.

Amantadine brand names

Amantadine is sold under the brand names Gocovri, Osmolex ER, Symadine and Symmetrel.

What is amantadine prescribed for?

Amantadine was originally developed as an antiviral drug to treat the flu⁠[1].

It is used to counteract the side effects of medication for Parkinson’s disease and can be used in combination with other drugs to directly treat symptoms of Parkinson’s disease⁠[2].

It can be prescribed for certain mental health disorders and other conditions related to the brain, such as:⁠[1]

Subject matter expert

\"\"

Leila Khurshid, Pharm.D.

Clinical pharmacy and medication

How does amantadine work?

As with many drugs, the exact mechanism of action by which amantadine works is not fully understood⁠[3]. It is an antiviral agent and prevents the flu virus from spreading. It affects the release of dopamine, a chemical in the brain that is involved in several processes in the body, including sleep, mood, attention and movement.

How is amantadine usually taken?

Amantadine comes in different forms, including capsules and tablets, slow-release capsules and tablets, and an oral liquid. Amantadine is usually taken once or twice a day and should be taken at the same time each day.

The dose will be decided by a doctor or mental health professional and will consider the severity of your symptoms and other conditions and medications.

How long does amantadine stay in your system?

Amantadine has a half-life of around 15 hours, on average, which is the time it takes for the body to break down and eliminate half of the dose. The half-life varies from person to person⁠[4].

Amantadine side effects

Like all medications,

Common side effects of amantadine include:⁠[2][4]

  • Dry mouth
  • Constipation, nausea and vomiting
  • Less of an appetite than usual
  • Sleep problems
  • Headaches
  • Drowsiness and confusion
  • Low blood pressure
  • Muscle spasms and contractions, problems walking
  • Purple or red marks on the skin

You should discuss side effects with your doctor.

If you feel drowsy or experience blurred vision, you should avoid driving and operating heavy machinery.

Seek medical attention for the following more serious side effects right away:⁠[2]

  • Hallucinations
  • Paranoia
  • Depression, low mood and/or anxiety
  • Suicidal ideation
  • Dizziness or fainting
  • Blurred vision
  • Swollen limbs, joints, hands or feet
  • Urinary retention
  • Shortness of breath

Some people have developed gambling problems or other compulsive behaviors after taking amantadine. Tell your doctor or healthcare provider if you become aware that you are developing intense urges to spend, eat, have sex or gamble⁠[2].

Amantadine precautions

Before prescribing amantadine, your doctor should discuss your medical history, any health problems you have, medications you are taking and any allergies. In particular, make sure you tell them:⁠[2]

  • If you are allergic to any of the ingredients in amantadine
  • Any other medication you are taking, including supplements and herbal remedies
  • If you have kidney disease
  • If you have or have had a problem with alcohol or other drugs
  • If you have any other physical or mental illness
  • If you are pregnant, trying for a baby or breastfeeding

You should not stop taking amantadine suddenly, as this can cause serious adverse effects, including psychosis, muscle problems, slurred speech, and fever⁠[2].

Amantadine interactions

Amantadine can interact with other medications, drugs and alcohol. Make sure you discuss any medication, supplement, herbal remedies or other substances you are taking with your doctor.

Amantadine can seriously interact with the dementia drug memantine, increasing the risk of central nervous system toxicity⁠[5]. It can also interact with other drugs that act on the central nervous system, such as levodopa (prescribed for Parkinson’s disease)⁠[4].

Taking amantadine with antipsychotic drugs can increase the risk of psychosis⁠[4].

Some diuretic medications can affect the rate at which amantadine is removed from the body, which can cause adverse reactions⁠[4].

Amantadine storage

Amantadine should be stored at room temperature (68-77°F or 20-25°C), away from light and moisture. Always keep medication with the original packaging to check the date and instructions for use. Keep all medication away from children⁠[2].

What to do if you overdose on amantadine

It is possible to overdose on amantadine. The symptoms of an overdose include:⁠[2]

  • Increased heart rate
  • Breathing problems
  • Reduced urination
  • Swollen limbs, joints, hands or feet
  • Stiffness of the limbs
  • Involuntary movement of parts of the body, including shaking
  • Difficulty with coordination
  • Confusion
  • Disassociation – feeling disconnected from yourself or your surroundings
  • Fear or anger
  • Hallucinations
  • Feeling lethargic

If you take too much amantadine, contact the Poison Helpline at 1-800-222-1222 or seek emergency medical help immediately.

What happens when you stop taking amantadine?

Do not stop taking amantadine without medical advice from your doctor. Suddenly stopping amantadine can lead to serious consequences, including psychosis, muscle problems, and fever⁠[2].

References

  1. Children’s Hospital of Eastern Ontario (CHEO). (n.d.). Amantadine: Medication Info Sheets. Children’s Hospital of Eastern Ontario (CHEO). ementalhealth.ca. Accessed October 10 2026.
  2. Amantadine: MedlinePlus Drug Information. (2021, June 15). MedlinePlus. MedlinePlus. Accessed October 10 2026.
  3. DailyMed - AMANTADINE capsule. (n.d.). Dailymed.nlm.nih.gov. DailyMed. Accessed October 10 2026.
  4. Amantadine hydrochloride 100mg capsules - Summary of Product Characteristics (SmPC). (n.d.). Electronic Medicines Compendium. Accessed November 15 2022. Original online source unavailable; citation retained.
  5. National Institute for Health and Care Excellence. (n.d.). Amantadine: Interactions. National Institute for Health and Care Excellence. bnf.nice.org.uk. Accessed November 15 2022.

Medical Content

The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.

About MentalHealth.com

MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.

\"\"

Author

Aimee Aveyard

Writer

Aimee Aveyard is a medical writer with 20+ years of experience in communications.

Published
Updated
\"\"

Medical Reviewer

Leila Khurshid, Pharm.D.

Pharm.D., BCPS

Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.

Reviewed
\"\"

Related community

Medications

Explore questions and perspectives about psychiatric medications and the treatment experience.

","text":"Home Library Medications Amantadine Amantadine Written by Aimee AveyardMedically reviewed by Leila Khurshid, Pharm.D. Published on November 23, 2022 · Updated on August 12, 2025 Amantadine is a medication that was originally developed as an influenza drug and is now primarily used to counteract the side effects of medication for Parkinson’s disease. It can also be used to treat certain mental health conditions, including obsessive-compulsive disorder, treatment-resistant depression and others, such as attention deficit hyperactivity disorder and autism. Key takeaways Amantadine is used for Parkinson-related symptoms and may be prescribed for selected mental health conditions. Side effects can include confusion, low blood pressure, hallucinations, and compulsive behaviors. Abrupt discontinuation can cause serious adverse effects, so treatment changes require medical guidance. Amantadine brand names Amantadine is sold under the brand names Gocovri, Osmolex ER, Symadine and Symmetrel. What is amantadine prescribed for? Amantadine was originally developed as an antiviral drug to treat the flu⁠[1]. It is used to counteract the side effects of medication for Parkinson’s disease and can be used in combination with other drugs to directly treat symptoms of Parkinson’s disease⁠[2]. It can be prescribed for certain mental health disorders and other conditions related to the brain, such as:⁠[1] Obsessive-compulsive disorder (OCD) Treatment-resistant depression Attention deficit hyperactivity disorder (ADHD) Autism spectrum disorder (ASD) Subject matter expert Leila Khurshid, Pharm.D. Clinical pharmacy and medication How does amantadine work? As with many drugs, the exact mechanism of action by which amantadine works is not fully understood⁠[3]. It is an antiviral agent and prevents the flu virus from spreading. It affects the release of dopamine, a chemical in the brain that is involved in several processes in the body, including sleep, mood, attention and movement. How is amantadine usually taken? Amantadine comes in different forms, including capsules and tablets, slow-release capsules and tablets, and an oral liquid. Amantadine is usually taken once or twice a day and should be taken at the same time each day. The dose will be decided by a doctor or mental health professional and will consider the severity of your symptoms and other conditions and medications. How long does amantadine stay in your system? Amantadine has a half-life of around 15 hours, on average, which is the time it takes for the body to break down and eliminate half of the dose. The half-life varies from person to person⁠[4]. Amantadine side effects Like all medications, Common side effects of amantadine include:⁠[2][4] Dry mouth Constipation, nausea and vomiting Less of an appetite than usual Sleep problems Headaches Drowsiness and confusion Low blood pressure Muscle spasms and contractions, problems walking Purple or red marks on the skin You should discuss side effects with your doctor. If you feel drowsy or experience blurred vision, you should avoid driving and operating heavy machinery. Seek medical attention for the following more serious side effects right away:⁠[2] Hallucinations Paranoia Depression, low mood and/or anxiety Suicidal ideation Dizziness or fainting Blurred vision Swollen limbs, joints, hands or feet Urinary retention Shortness of breath Some people have developed gambling problems or other compulsive behaviors after taking amantadine. Tell your doctor or healthcare provider if you become aware that you are developing intense urges to spend, eat, have sex or gamble⁠[2]. Amantadine precautions Before prescribing amantadine, your doctor should discuss your medical history, any health problems you have, medications you are taking and any allergies. In particular, make sure you tell them:⁠[2] If you are allergic to any of the ingredients in amantadine Any other medication you are taking, including supplements and herbal remedies If you have kidney disease If you have or have had a problem with alcohol or other drugs If you have any other physical or mental illness If you are pregnant, trying for a baby or breastfeeding You should not stop taking amantadine suddenly, as this can cause serious adverse effects, including psychosis, muscle problems, slurred speech, and fever⁠[2]. Amantadine interactions Amantadine can interact with other medications, drugs and alcohol. Make sure you discuss any medication, supplement, herbal remedies or other substances you are taking with your doctor. Amantadine can seriously interact with the dementia drug memantine, increasing the risk of central nervous system toxicity⁠[5]. It can also interact with other drugs that act on the central nervous system, such as levodopa (prescribed for Parkinson’s disease)⁠[4]. Taking amantadine with antipsychotic drugs can increase the risk of psychosis⁠[4]. Some diuretic medications can affect the rate at which amantadine is removed from the body, which can cause adverse reactions⁠[4]. Amantadine storage Amantadine should be stored at room temperature (68-77°F or 20-25°C), away from light and moisture. Always keep medication with the original packaging to check the date and instructions for use. Keep all medication away from children⁠[2]. What to do if you overdose on amantadine It is possible to overdose on amantadine. The symptoms of an overdose include:⁠[2] Increased heart rate Breathing problems Reduced urination Swollen limbs, joints, hands or feet Stiffness of the limbs Involuntary movement of parts of the body, including shaking Difficulty with coordination Confusion Disassociation – feeling disconnected from yourself or your surroundings Fear or anger Hallucinations Feeling lethargic If you take too much amantadine, contact the Poison Helpline at 1-800-222-1222 or seek emergency medical help immediately. What happens when you stop taking amantadine? Do not stop taking amantadine without medical advice from your doctor. Suddenly stopping amantadine can lead to serious consequences, including psychosis, muscle problems, and fever⁠[2]. References Children’s Hospital of Eastern Ontario (CHEO). (n.d.). Amantadine: Medication Info Sheets. Children’s Hospital of Eastern Ontario (CHEO). ementalhealth.ca. Accessed October 10 2026. Amantadine: MedlinePlus Drug Information. (2021, June 15). MedlinePlus. MedlinePlus. Accessed October 10 2026. DailyMed - AMANTADINE capsule. (n.d.). Dailymed.nlm.nih.gov. DailyMed. Accessed October 10 2026. Amantadine hydrochloride 100mg capsules - Summary of Product Characteristics (SmPC). (n.d.). Electronic Medicines Compendium. Accessed November 15 2022. Original online source unavailable; citation retained. National Institute for Health and Care Excellence. (n.d.). Amantadine: Interactions. National Institute for Health and Care Excellence. bnf.nice.org.uk. Accessed November 15 2022. Medical Content The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy. About MentalHealth.com MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life. Author Aimee Aveyard Writer Aimee Aveyard is a medical writer with 20+ years of experience in communications. Published November 23, 2022 Updated August 12, 2025 Medical Reviewer Leila Khurshid, Pharm.D. Pharm.D., BCPS Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital. Reviewed November 25, 2022 Related community Medications Explore questions and perspectives about psychiatric medications and the treatment experience. Table of contentsChoose a section Amantadine brand names What is amantadine prescribed for? How does amantadine work? How is amantadine usually taken? How long does amantadine stay in your system? Amantadine side effects Amantadine precautions Amantadine interactions Amantadine storage What to do if you overdose on amantadine What happens when you stop taking amantadine? 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