{"formatVersion":"1.1","id":"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing","path":"/library/diagnosing-alzheimers-neuropsychological-testing","url":"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing","title":"Diagnosing Alzheimer’s Disease","family":"Library detail","description":"Learn how Alzheimer's disease is diagnosed using clinical evaluations, cognitive testing, and established diagnostic criteria.","language":"en-US","access":{"audience":"public","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing","wordpressId":"4726","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://www.mentalhealth.com/people/erin-george#person","name":"Erin L. George","url":"https://www.mentalhealth.com/people/erin-george"}],"reviewer":{"@type":"Person","@id":"https://www.mentalhealth.com/people/morgan-blair#person","name":"Morgan Blair","url":"https://www.mentalhealth.com/people/morgan-blair"},"dates":{"datePublished":"2025-05-14T12:14:04Z","dateModified":"2026-05-14T19:04:13Z","lastReviewed":"2025-05-14"},"content":{"html":"<nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\"><ol><li><a href=\"https://www.mentalhealth.com/\">Home</a></li><li><a href=\"https://www.mentalhealth.com/library\">Library</a></li><li><a href=\"https://www.mentalhealth.com/library/assessments-diagnosis\">Assessments &amp; Diagnosis</a></li><li><span aria-current=\"page\">Diagnosing Alzheimer’s Disease</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard=\"\"><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Diagnosing Alzheimer’s Disease</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/erin-george\"><img alt=\"\" height=\"22\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/3e6614c23a1205b91bc9e56a.jpg\" width=\"22\" decoding=\"async\">Erin L. George</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/morgan-blair\"><img alt=\"\" height=\"22\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/9f1be5c5cc2b412cfab5f6cc.jpg\" width=\"22\" decoding=\"async\">Morgan Blair</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2025-05-14T12:14:04Z\">May 14, 2025</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2026-05-14T19:04:13Z\">May 14, 2026</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Alzheimer's disease is a progressive brain disorder that causes ongoing damage to cognitive function, making early diagnosis essential. While many people are familiar with its common symptoms, the early signs are often subtle and easily overlooked. </p><p>Diagnosing Alzheimer's accurately requires a comprehensive medical evaluation, which is why it's crucial to increase awareness about the diagnostic process. Sharing reliable information helps individuals and families recognize symptoms sooner and seek timely support.</p></div><figure class=\"article-feature\"><img alt=\"Older friends smile and gesture while sitting together on a sofa.\" decoding=\"async\" height=\"800\" loading=\"eager\" src=\"https://www.mentalhealth.com/assets/optimized/fd7ee00d88a6db39c95759b4.webp\" width=\"1200\" srcset=\"/assets/responsive/9fa9c1a3acbdcdeebaeb910b.webp 800w, /assets/optimized/fd7ee00d88a6db39c95759b4.webp 1200w\" sizes=\"(max-width: 800px) 100vw, 1200px\"></figure><section aria-labelledby=\"key-takeaways\" class=\"article-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Alzheimer’s diagnosis involves a comprehensive evaluation of cognitive changes, medical history, and daily functioning.</li><li>Cognitive testing, neurological examinations, imaging, and laboratory investigations help assess symptoms and rule out other causes.</li><li>Earlier recognition can improve access to care, symptom management, and planning for future support.</li></ul></section><span id=\"what-is-alzheimer-s-disease\" class=\"section-anchor-alias\" data-section-alias=\"what-is-alzheimers-disease\" aria-hidden=\"true\"></span><h2 id=\"what-is-alzheimers-disease\">What Is Alzheimer’s disease?</h2><p>Alzheimer’s disease is the most common type of dementia among older adults and is the fourth leading cause of death in people over the age of 65, following heart disease, cancer, and stroke. It’s a <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/cognitive-disorders\">cognitive disorder</a> that develops gradually and worsens over time, mainly affecting memory. </p><p>People with Alzheimer’s may also have trouble speaking, performing daily tasks, or recognizing familiar people and things. They often experience problems with judgment, decision-making, and knowing where they are or what time it is⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#current-challenges-early-detection-alzheimer-s-disease-brain-imaging\" data-reference-link=\"\" aria-label=\"Reference 1: Mistur, R., Mosconi, L., De Santi, S., Guzman, M., Li, Y., Tsui, W., et al. (2009). Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies. Journal of Clinical Neurology, 5(4), 153–166. thejcn.com. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>. </p><p>Currently, there is no single test that can definitively diagnose Alzheimer’s while a person is still alive. Doctors usually diagnose it by observing behavior and ruling out other conditions. Unfortunately, this approach makes it harder to catch the disease early and limits research on how to prevent it. Experts estimate that up to 90% of <a href=\"https://www.mentalhealth.com/library/dementia\" class=\"article-inline-link\" data-context-link=\"355\">dementia</a> cases go undetected in standard medical exams⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#current-challenges-early-detection-alzheimer-s-disease-brain-imaging\" data-reference-link=\"\" aria-label=\"Reference 1: Mistur, R., Mosconi, L., De Santi, S., Guzman, M., Li, Y., Tsui, W., et al. (2009). Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies. Journal of Clinical Neurology, 5(4), 153–166. thejcn.com. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><section aria-label=\"Subject matter expert\" class=\"article-expert article-expert-inline\" data-expert-kind=\"related\" data-expert-layout=\"standard\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><a href=\"https://www.mentalhealth.com/people/natalie-staats-reiss\" class=\"card-identity-photo\" aria-label=\"Natalie Staats Reiss  Ph.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/f740e834778e6cf83ef499f0.jpg\" width=\"64\" decoding=\"async\"></a><h2><a href=\"https://www.mentalhealth.com/people/natalie-staats-reiss\">Natalie Staats Reiss <span class=\"expert-credentials\">Ph.D.</span></a></h2></div><p class=\"article-expert-focus\">Older adults and caregivers</p></section><h2 id=\"initial-assessment\">Initial Assessment</h2><p>For suspected Alzheimer's disease, healthcare providers must perform an initial assessment to determine if an individual is suffering from the disorder and how advanced the symptoms are. A person's primary care physician (PCP) conducts an early Alzheimer's test. During the first appointment, the primary care physician will ask the patient about their symptoms and thoroughly examine all possible options.</p><p>The PCP will gather the patient's medical history to identify anything that may indicate early-onset dementia, which may later become Alzheimer's. They may also request family input to determine precisely how the individual's behavior or personality has changed and to determine if there is a family history of Alzheimer's. All of this information is pertinent when analyzing the existence and severity of symptoms⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#alzheimers-disease-diagnosed\" data-reference-link=\"\" aria-label=\"Reference 2: National Institute on Aging. (2022, December 8). How is Alzheimer’s disease diagnosed? National Institute on Aging. National Institute on Aging. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.</p><p>In some cases, the PCP may order blood or urine tests to help identify any other underlying medical issues. They may also test things like vision and hearing. They must rule out any other possibilities to avoid a misdiagnosis. Still, if they strongly suspect Alzheimer's disease, they will move on to organizing more cognitive tests⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#alzheimers-disease-diagnosed\" data-reference-link=\"\" aria-label=\"Reference 2: National Institute on Aging. (2022, December 8). How is Alzheimer’s disease diagnosed? National Institute on Aging. National Institute on Aging. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>. </p><h2 id=\"cognitive-and-neuropsychological-tests\">Cognitive and Neuropsychological Tests</h2><p>Several cognitive symptoms may indicate the onset of Alzheimer’s disease. These early warning signs include:</p><ul class=\"wp-block-list\">\n<li>Frequent memory lapses, especially forgetting recently learned information.</li>\n<li>Sudden or unexplained changes in personality or mood.</li>\n<li>Difficulty with spatial awareness or visual perception, such as judging distances.</li>\n<li>Trouble maintaining attention or staying focused.</li>\n<li>Repeating questions or statements in the same conversation.</li>\n<li>Becoming disoriented or getting lost in familiar places.</li>\n<li>Struggling to complete routine tasks that were once simple.</li>\n</ul><p>When these symptoms appear, a primary care physician (PCP) typically conducts initial neuropsychological evaluations. These tests assess a person's memory, problem-solving skills, attention, and language abilities to detect cognitive impairment. </p><p>The results help determine whether more advanced diagnostic procedures, such as brain imaging or laboratory tests, are necessary to confirm an Alzheimer’s diagnosis and rule out other possible causes. Early detection is critical for effective care planning and treatment⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#alzheimers-disease-fact-sheet\" data-reference-link=\"\" aria-label=\"Reference 3: National Institute on Aging. (2023). Alzheimer’s disease fact sheet. National Institute on Aging; National Institutes of Health. National Institute on Aging. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a></sup>. </p><p>Some of the most common and effective cognitive and behavioral tests include:</p><ul class=\"wp-block-list\">\n<li><strong>The mini-cog</strong>: This three-minute memory test requires patients to draw a clock accurately. A healthcare professional will review the results and decide if an in-depth follow-up assessment is needed.</li>\n<li><strong>The General Practitioner Assessment of Cognition</strong> <strong>(GPAC)</strong>: This is a test that screens individuals for signs of cognitive impairment. The patient first takes Part 1 of the test; if they fail, they must also complete Part 2.</li>\n<li><strong>The 8-item informant interview to differentiate aging and dementia: </strong>A questionnaire-style interview used to gather more information and distinguish between typical signs of aging and early dementia⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#cognitive-assessment\" data-reference-link=\"\" aria-label=\"Reference 4: Alzheimer’s Association. (2022). Cognitive Assessment. Alzheimer’s Disease and Dementia. Alzheimer’s Association. Accessed October 10 2026.\" data-reference-number=\"4\">[4]</a></sup>. </li>\n</ul><p>Overall, health providers want to test an individual's core cognitive abilities. They need to examine how well a patient can retain and recall information, whether they can logically solve problems, how they communicate, their attention to detail, and their level of comprehension.</p><h2 id=\"physical-and-neurological-tests\">Physical and Neurological Tests</h2><p>Though <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/alzheimers-disease\">Alzheimer's is a brain disease</a>, it's also essential to carry out physical and neurological tests to help rule out other potential conditions and analyze any physical symptoms that could impact an individual's quality of life.</p><p>During a physical and neurological examination for an Alzheimer's diagnosis, the PCP will usually consider factors like:</p><ul class=\"wp-block-list\">\n<li>The patient's diet and alcohol consumption.</li>\n<li>Blood pressure and heart rate.</li>\n<li>The patient's level of regular exercise.</li>\n<li>Testing blood and urine samples.</li>\n<li>Any medications the patient is taking.</li>\n<li>The patient's usual quality of sleep⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#medical-tests-diagnosing-alzheimers\" data-reference-link=\"\" aria-label=\"Reference 5: Alzheimer’s Association. (2024). Medical Tests for Diagnosing Alzheimer’s. Alzheimer’s Disease and Dementia; Alzheimer’s Association. Alzheimer’s Association. Accessed October 10 2026.\" data-reference-number=\"5\">[5]</a></sup>.</li>\n</ul><p>Testing and examining these factors can help to distinguish symptoms of Alzheimer's from other conditions that present similar symptoms. The patient could be suffering from a variety of different ailments, such as vitamin deficiency, sleep apnea, thyroid issues, side effects brought on by medications, and even <a href=\"https://www.mentalhealth.com/library/depression\" class=\"article-inline-link\" data-context-link=\"355\">depression</a>.<strong> </strong></p><p>Physicians are trained to recognize the signs of Alzheimer’s disease and will proceed with additional assessments if they suspect a patient may be affected⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#medical-tests-diagnosing-alzheimers\" data-reference-link=\"\" aria-label=\"Reference 5: Alzheimer’s Association. (2024). Medical Tests for Diagnosing Alzheimer’s. Alzheimer’s Disease and Dementia; Alzheimer’s Association. Alzheimer’s Association. Accessed October 10 2026.\" data-reference-number=\"5\">[5]</a></sup>. </p><h2 id=\"brain-imaging-techniques\">Brain Imaging Techniques</h2><p>If healthcare professionals suspect Alzheimer's disease, they will propose brain imaging tests to analyze and monitor how the disorder is changing an individual's brain. As the disease progresses, it is essential to manage its development and note where most of the damage occurs⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#brain-imaging-alzheimer-disease\" data-reference-link=\"\" aria-label=\"Reference 6: Johnson, K. A., Fox, N. C., Sperling, R. A., &amp; Klunk, W. E. (2012). Brain Imaging in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine, 2(4), a006213–a006213. perspectivesinmedicine.cshlp.org. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a></sup>. </p><p>There are three primary brain imaging techniques involved in early Alzheimer's testing:</p><ul class=\"wp-block-list\">\n<li><strong>Computed Tomography (CT) p</strong>rovides  X-ray images of the brain's structure to help identify causes of cognitive decline and any signs of shrinkage, fluid, or blood.</li>\n<li><strong>Magnetic resonance imaging (MRI)</strong> provides more detailed brain images, offering insight into structural and vascular damage.</li>\n<li><strong>Positron Emission Tomography (PET) </strong>creates 3D images of the brain, highlighting its structural and metabolic activity, using radioactive technology to trace disease and injury.</li>\n</ul><p>With images provided by CT, MRI, and PET scans, medical professionals can make more informed decisions about diagnosing Alzheimer's in a patient, determining the current stage of the disease, and selecting appropriate treatment therapies⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#brain-imaging-alzheimer-disease\" data-reference-link=\"\" aria-label=\"Reference 6: Johnson, K. A., Fox, N. C., Sperling, R. A., &amp; Klunk, W. E. (2012). Brain Imaging in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine, 2(4), a006213–a006213. perspectivesinmedicine.cshlp.org. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a></sup>. </p><h2 id=\"laboratory-tests-and-biomarkers\">Laboratory Tests and Biomarkers</h2><p>After all the initial assessments, the tests for an Alzheimer's diagnosis become more extensive, but this is necessary for accurately examining and monitoring a patient's symptoms. Medical professionals may carry out blood tests to check for signs of Alzheimer's disease, though they can usually confirm the diagnosis via a brain scan.</p><p>Researchers are actively developing blood tests to improve the diagnosis of Alzheimer’s disease, focusing on detecting specific biomarkers linked to the condition. These tests analyze blood samples for proteins such as amyloid beta and tau, which are commonly associated with Alzheimer’s. When these proteins accumulate in the brain, they can enter the bloodstream, providing a potential pathway for early detection. </p><p>New and more precise biomarker tests are showing encouraging results, offering hope for less invasive, faster, and more accurate diagnostic tools that could transform how Alzheimer’s is diagnosed and managed in the future⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#accurate-blood-test-alzheimers-disease\" data-reference-link=\"\" aria-label=\"Reference 7: Reynolds, S. (2024, August 13). Accurate blood test for Alzheimer’s disease. National Institutes of Health (NIH). National Institutes of Health. Accessed October 10 2026.\" data-reference-number=\"7\">[7]</a></sup>. </p><h2 id=\"genetic-testing-for-alzheimer-s\">Genetic Testing for Alzheimer's</h2><p>There are currently no reliable genetic tests available for those suffering from Alzheimer's disease, so it's not even a feasible option for family members who have relatives with the disorder, which could be genetically transmitted.</p><p>Researchers are actively developing blood tests to improve the diagnosis of Alzheimer’s disease, focusing on detecting specific biomarkers linked to the condition. These genetic tests for Alzheimer’s disease analyze blood samples for proteins such as amyloid beta and tau, which are commonly associated with the disease. </p><p>When these proteins accumulate in the brain, they can enter the bloodstream, providing a potential pathway for early detection. New and more precise biomarker tests are showing encouraging results, offering hope for less invasive, faster, and more accurate diagnostic tools that could transform how Alzheimer’s is diagnosed and managed in the future⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#alzheimers-disease-fact-sheet\" data-reference-link=\"\" aria-label=\"Reference 3: National Institute on Aging. (2023). Alzheimer’s disease fact sheet. National Institute on Aging; National Institutes of Health. National Institute on Aging. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a></sup>. </p><h2 id=\"differential-diagnosis\">Differential Diagnosis</h2><p>The symptoms of Alzheimer's disease are often very similar to those of other brain diseases that affect the brain. That's why so much invasive and extensive testing is required to differentiate between symptoms and ensure an accurate Alzheimer's diagnosis.</p><p>Memory problems are common in individuals who have experienced traumatic brain injury, stroke, or the growth of a tumor. Healthcare professionals use brain scans and blood tests to differentiate these symptoms from those of Alzheimer's. People who have Parkinson's disease also suffer similar cognitive problems to those with Alzheimer's, particularly memory loss, confused thinking, and difficulty performing specific everyday tasks. Distinguishing between the two is integral for appropriate patient care⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#alzheimers-disease-diagnosed\" data-reference-link=\"\" aria-label=\"Reference 2: National Institute on Aging. (2022, December 8). How is Alzheimer’s disease diagnosed? National Institute on Aging. National Institute on Aging. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>. </p><p>At times, a patient may have an infection or nutrient deficiency that mimics the early signs of Alzheimer’s disease. Even if these symptoms appear mild, it’s important to investigate them thoroughly to determine if Alzheimer’s is the underlying cause. </p><p>Additionally, Alzheimer’s is not the only form of dementia. Other types—such as vascular dementia and Lewy body dementia—can produce similar symptoms in the early stages. A primary care physician (PCP) can recommend the appropriate tests to help differentiate between these conditions and ensure an accurate diagnosis⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#alzheimers-disease-diagnosed\" data-reference-link=\"\" aria-label=\"Reference 2: National Institute on Aging. (2022, December 8). How is Alzheimer’s disease diagnosed? National Institute on Aging. National Institute on Aging. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.  </p><h2 id=\"challenges-in-early-diagnosis-of-alzheimer-s\">Challenges in Early Diagnosis of Alzheimer's</h2><p>Currently, there is no cure for Alzheimer’s disease, though several medications can help manage its symptoms and slow progression.</p><p>One of the primary challenges in diagnosing Alzheimer’s is early detection. Biomarker tests show promise for identifying subtle brain changes that may not be visible through standard imaging techniques until the disease has advanced. Accurate identification of early-onset Alzheimer’s would allow individuals to better recognize warning signs and take proactive steps if they are at risk⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#current-challenges-early-detection-alzheimer-s-disease-brain-imaging\" data-reference-link=\"\" aria-label=\"Reference 1: Mistur, R., Mosconi, L., De Santi, S., Guzman, M., Li, Y., Tsui, W., et al. (2009). Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies. Journal of Clinical Neurology, 5(4), 153–166. thejcn.com. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>. </p><p>Improved detection tools, such as brain imaging and blood-based biomarker tests, could streamline diagnosis. Until such technology becomes widely accessible, early consultation with a healthcare provider remains essential at the first sign of symptoms⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#current-challenges-early-detection-alzheimer-s-disease-brain-imaging\" data-reference-link=\"\" aria-label=\"Reference 1: Mistur, R., Mosconi, L., De Santi, S., Guzman, M., Li, Y., Tsui, W., et al. (2009). Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies. Journal of Clinical Neurology, 5(4), 153–166. thejcn.com. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>. </p><span id=\"why-early-diagnosis-of-alzheimer-s-matters\" class=\"section-anchor-alias\" data-section-alias=\"why-early-diagnosis-of-alzheimers-matters\" aria-hidden=\"true\"></span><h2 id=\"why-early-diagnosis-of-alzheimers-matters\">Why Early Diagnosis of Alzheimer’s Matters</h2><p>Diagnosing Alzheimer's disease is a complex and multifaceted process that involves a variety of thorough evaluations, including cognitive, neurological, and physical assessments, as well as advanced imaging techniques and biomarker testing. </p><p>Early diagnosis of Alzheimer's is critical, as it allows patients and their families to access vital treatment options and plan for the future while managing symptoms effectively. Understanding the diagnostic process also helps differentiate Alzheimer's from other conditions with similar symptoms, helping to avoid misdiagnosis and ensure appropriate care. </p><p>Seeking professional medical help at the first signs of cognitive decline is essential. Healthcare providers have the expertise and tools to perform comprehensive evaluations and rule out reversible causes or other disorders. Early intervention preserves cognitive function for longer and empowers patients and their families to make informed decisions about their health and well-being.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" data-reference-list=\"\" data-reference-style=\"author-date-title-source\" data-source-references=\"\" id=\"references\"><h2 id=\"references-2\">References</h2><ol><li id=\"current-challenges-early-detection-alzheimer-s-disease-brain-imaging\" value=\"1\" data-reference-number=\"1\" data-reference-format=\"393\">Mistur, R., Mosconi, L., De Santi, S., Guzman, M., Li, Y., Tsui, W., et al. (2009). <em class=\"reference-title\">Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies.</em> Journal of Clinical Neurology, 5(4), 153–166. <a href=\"https://www.thejcn.com/DOIx.php?id=10.3988%2Fjcn.2009.5.4.153&amp;utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">thejcn.com</a>. Accessed October 10 2026.</li><li id=\"alzheimers-disease-diagnosed\" value=\"2\" data-reference-number=\"2\" data-reference-format=\"393\">National Institute on Aging. (2022, December 8). <em class=\"reference-title\">How is Alzheimer’s disease diagnosed?</em> National Institute on Aging. <a href=\"https://www.nia.nih.gov/health/alzheimers-symptoms-and-diagnosis/how-alzheimers-disease-diagnosed?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Institute on Aging</a>. Accessed October 10 2026.</li><li id=\"alzheimers-disease-fact-sheet\" value=\"3\" data-reference-number=\"3\" data-reference-format=\"393\">National Institute on Aging. (2023). <em class=\"reference-title\">Alzheimer’s disease fact sheet.</em> National Institute on Aging; National Institutes of Health. <a href=\"https://www.nia.nih.gov/health/alzheimers-and-dementia/alzheimers-disease-fact-sheet?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Institute on Aging</a>. Accessed October 10 2026.</li><li id=\"cognitive-assessment\" value=\"4\" data-reference-number=\"4\" data-reference-format=\"393\">Alzheimer’s Association. (2022). <em class=\"reference-title\">Cognitive Assessment.</em> Alzheimer’s Disease and Dementia. <a href=\"https://www.alz.org/professionals/health-systems-medical-professionals/cognitive-assessment?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">Alzheimer’s Association</a>. Accessed October 10 2026.</li><li id=\"medical-tests-diagnosing-alzheimers\" value=\"5\" data-reference-number=\"5\" data-reference-format=\"393\">Alzheimer’s Association. (2024). <em class=\"reference-title\">Medical Tests for Diagnosing Alzheimer’s.</em> Alzheimer’s Disease and Dementia; Alzheimer’s Association. <a href=\"https://www.alz.org/alzheimers-dementia/diagnosis/medical_tests?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">Alzheimer’s Association</a>. Accessed October 10 2026.</li><li id=\"brain-imaging-alzheimer-disease\" value=\"6\" data-reference-number=\"6\" data-reference-format=\"393\">Johnson, K. A., Fox, N. C., Sperling, R. A., &amp; Klunk, W. E. (2012). <em class=\"reference-title\">Brain Imaging in Alzheimer Disease.</em> Cold Spring Harbor Perspectives in Medicine, 2(4), a006213–a006213. <a href=\"https://perspectivesinmedicine.cshlp.org/content/2/4/a006213?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">perspectivesinmedicine.cshlp.org</a>. Accessed October 10 2026.</li><li id=\"accurate-blood-test-alzheimers-disease\" value=\"7\" data-reference-number=\"7\" data-reference-format=\"393\">Reynolds, S. (2024, August 13). <em class=\"reference-title\">Accurate blood test for Alzheimer’s disease.</em> National Institutes of Health (NIH). <a href=\"https://www.nih.gov/news-events/nih-research-matters/accurate-blood-test-alzheimer-s-disease?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-diagnosing-alzheimers-neuropsychological-testing&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Institutes of Health</a>. Accessed October 10 2026.</li></ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://www.mentalhealth.com/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://www.mentalhealth.com/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/erin-george\" class=\"card-identity-photo\" aria-label=\"Erin L. George\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/3e6614c23a1205b91bc9e56a.jpg\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Author</p><h3 id=\"erin-l-george\"><a href=\"https://www.mentalhealth.com/people/erin-george\">Erin L. George</a></h3><p class=\"article-bio-credentials\">MFT</p><p>Erin L. George, MFT, holds a master's degree in family therapy with a focus on group dynamics in high-risk families. As a court-appointed special advocate for children, she is dedicated to helping families rebuild relationships and improve their mental and behavioral health.</p><dl><div><dt>Published</dt><dd><time datetime=\"2025-05-14T12:14:04Z\">May 14, 2025</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2026-05-14T19:04:13Z\">May 14, 2026</time></dd></div></dl></div></section><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/morgan-blair\" class=\"card-identity-photo\" aria-label=\"Morgan Blair, M.A.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/9f1be5c5cc2b412cfab5f6cc.jpg\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"morgan-blair\"><a href=\"https://www.mentalhealth.com/people/morgan-blair\">Morgan Blair, M.A.</a></h3><p class=\"article-bio-credentials\">MA, LPCC</p><p>Morgan Blair is a licensed therapist, writer and medical reviewer, holding a master’s degree in clinical mental health counseling from Northwestern University.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2025-05-14\">May 14, 2025</time></dd></div></dl></div></section></div></section><section aria-label=\"Related community\" class=\"article-topic-community article-topic-community-end\"><a href=\"https://www.mentalhealth.com/community/medical-conditions\" class=\"card-identity-photo\" aria-label=\"Medical Conditions\"><img alt=\"\" class=\"topic-community-banner\" height=\"800\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/a46170681b759d25479d8b00.webp\" width=\"1200\" decoding=\"async\" srcset=\"/assets/responsive/94ca6929953fe41e502b8634.webp 800w, /assets/optimized/a46170681b759d25479d8b00.webp 1200w\" sizes=\"(min-width: 961px) 236px, calc(100vw - 80px)\"></a><p class=\"topic-community-label\">Related community</p><h2><a href=\"https://www.mentalhealth.com/community/medical-conditions\">Medical Conditions</a></h2><p>Explore the connections between physical health conditions and mental well-being.</p></section></div></div><aside aria-label=\"Article navigation and related information\" class=\"article-sidebar\" data-bounded-rail=\"\" tabindex=\"0\"><details class=\"article-contents\" data-expanded=\"false\" data-scrolled-past=\"false\" data-section-preview=\"3\" open=\"\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a aria-label=\"What Is Alzheimer’s disease?\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#what-is-alzheimers-disease\" title=\"What Is Alzheimer’s disease?\">What Is Alzheimer’s disease?</a></li><li><a aria-label=\"Initial Assessment\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#initial-assessment\" title=\"Initial Assessment\">Initial Assessment</a></li><li><a aria-label=\"Cognitive and Neuropsychological Tests\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#cognitive-and-neuropsychological-tests\" title=\"Cognitive and Neuropsychological Tests\">Cognitive and Neuropsychological Tests</a></li><li><a aria-label=\"Physical and Neurological Tests\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#physical-and-neurological-tests\" title=\"Physical and Neurological Tests\">Physical and Neurological Tests</a></li><li><a aria-label=\"Brain Imaging Techniques\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#brain-imaging-techniques\" title=\"Brain Imaging Techniques\">Brain Imaging Techniques</a></li><li><a aria-label=\"Laboratory Tests and Biomarkers\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#laboratory-tests-and-biomarkers\" title=\"Laboratory Tests and Biomarkers\">Laboratory Tests and Biomarkers</a></li><li><a aria-label=\"Genetic Testing for Alzheimer's\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#genetic-testing-for-alzheimer-s\" title=\"Genetic Testing for Alzheimer's\">Genetic Testing for Alzheimer's</a></li><li><a aria-label=\"Differential Diagnosis\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#differential-diagnosis\" title=\"Differential Diagnosis\">Differential Diagnosis</a></li><li><a aria-label=\"Challenges in Early Diagnosis of Alzheimer's\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#challenges-in-early-diagnosis-of-alzheimer-s\" title=\"Challenges in Early Diagnosis of Alzheimer's\">Challenges in Early Diagnosis of Alzheimer's</a></li><li><a aria-label=\"Why Early Diagnosis of Alzheimer’s Matters\" href=\"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#why-early-diagnosis-of-alzheimers-matters\" title=\"Why Early Diagnosis of Alzheimer’s Matters\">Why Early Diagnosis of Alzheimer’s Matters</a></li></ol><button aria-controls=\"article-section-list\" aria-expanded=\"false\" class=\"article-sections-toggle\" data-sections-toggle=\"\" type=\"button\">View more</button></nav></details></aside></div></div></div>","text":"Home Library Assessments & Diagnosis Diagnosing Alzheimer’s Disease Diagnosing Alzheimer’s Disease Written by Erin L. GeorgeMedically reviewed by Morgan Blair Published on May 14, 2025 · Updated on May 14, 2026 Alzheimer's disease is a progressive brain disorder that causes ongoing damage to cognitive function, making early diagnosis essential. While many people are familiar with its common symptoms, the early signs are often subtle and easily overlooked. Diagnosing Alzheimer's accurately requires a comprehensive medical evaluation, which is why it's crucial to increase awareness about the diagnostic process. Sharing reliable information helps individuals and families recognize symptoms sooner and seek timely support. Key takeaways Alzheimer’s diagnosis involves a comprehensive evaluation of cognitive changes, medical history, and daily functioning. Cognitive testing, neurological examinations, imaging, and laboratory investigations help assess symptoms and rule out other causes. Earlier recognition can improve access to care, symptom management, and planning for future support. What Is Alzheimer’s disease? Alzheimer’s disease is the most common type of dementia among older adults and is the fourth leading cause of death in people over the age of 65, following heart disease, cancer, and stroke. It’s a cognitive disorder that develops gradually and worsens over time, mainly affecting memory. People with Alzheimer’s may also have trouble speaking, performing daily tasks, or recognizing familiar people and things. They often experience problems with judgment, decision-making, and knowing where they are or what time it is⁠[1]. Currently, there is no single test that can definitively diagnose Alzheimer’s while a person is still alive. Doctors usually diagnose it by observing behavior and ruling out other conditions. Unfortunately, this approach makes it harder to catch the disease early and limits research on how to prevent it. Experts estimate that up to 90% of dementia cases go undetected in standard medical exams⁠[1]. Subject matter expert Natalie Staats Reiss Ph.D. Older adults and caregivers Initial Assessment For suspected Alzheimer's disease, healthcare providers must perform an initial assessment to determine if an individual is suffering from the disorder and how advanced the symptoms are. A person's primary care physician (PCP) conducts an early Alzheimer's test. During the first appointment, the primary care physician will ask the patient about their symptoms and thoroughly examine all possible options. The PCP will gather the patient's medical history to identify anything that may indicate early-onset dementia, which may later become Alzheimer's. They may also request family input to determine precisely how the individual's behavior or personality has changed and to determine if there is a family history of Alzheimer's. All of this information is pertinent when analyzing the existence and severity of symptoms⁠[2]. In some cases, the PCP may order blood or urine tests to help identify any other underlying medical issues. They may also test things like vision and hearing. They must rule out any other possibilities to avoid a misdiagnosis. Still, if they strongly suspect Alzheimer's disease, they will move on to organizing more cognitive tests⁠[2]. Cognitive and Neuropsychological Tests Several cognitive symptoms may indicate the onset of Alzheimer’s disease. These early warning signs include: Frequent memory lapses, especially forgetting recently learned information. Sudden or unexplained changes in personality or mood. Difficulty with spatial awareness or visual perception, such as judging distances. Trouble maintaining attention or staying focused. Repeating questions or statements in the same conversation. Becoming disoriented or getting lost in familiar places. Struggling to complete routine tasks that were once simple. When these symptoms appear, a primary care physician (PCP) typically conducts initial neuropsychological evaluations. These tests assess a person's memory, problem-solving skills, attention, and language abilities to detect cognitive impairment. The results help determine whether more advanced diagnostic procedures, such as brain imaging or laboratory tests, are necessary to confirm an Alzheimer’s diagnosis and rule out other possible causes. Early detection is critical for effective care planning and treatment⁠[3]. Some of the most common and effective cognitive and behavioral tests include: The mini-cog: This three-minute memory test requires patients to draw a clock accurately. A healthcare professional will review the results and decide if an in-depth follow-up assessment is needed. The General Practitioner Assessment of Cognition (GPAC): This is a test that screens individuals for signs of cognitive impairment. The patient first takes Part 1 of the test; if they fail, they must also complete Part 2. The 8-item informant interview to differentiate aging and dementia: A questionnaire-style interview used to gather more information and distinguish between typical signs of aging and early dementia⁠[4]. Overall, health providers want to test an individual's core cognitive abilities. They need to examine how well a patient can retain and recall information, whether they can logically solve problems, how they communicate, their attention to detail, and their level of comprehension. Physical and Neurological Tests Though Alzheimer's is a brain disease, it's also essential to carry out physical and neurological tests to help rule out other potential conditions and analyze any physical symptoms that could impact an individual's quality of life. During a physical and neurological examination for an Alzheimer's diagnosis, the PCP will usually consider factors like: The patient's diet and alcohol consumption. Blood pressure and heart rate. The patient's level of regular exercise. Testing blood and urine samples. Any medications the patient is taking. The patient's usual quality of sleep⁠[5]. Testing and examining these factors can help to distinguish symptoms of Alzheimer's from other conditions that present similar symptoms. The patient could be suffering from a variety of different ailments, such as vitamin deficiency, sleep apnea, thyroid issues, side effects brought on by medications, and even depression. Physicians are trained to recognize the signs of Alzheimer’s disease and will proceed with additional assessments if they suspect a patient may be affected⁠[5]. Brain Imaging Techniques If healthcare professionals suspect Alzheimer's disease, they will propose brain imaging tests to analyze and monitor how the disorder is changing an individual's brain. As the disease progresses, it is essential to manage its development and note where most of the damage occurs⁠[6]. There are three primary brain imaging techniques involved in early Alzheimer's testing: Computed Tomography (CT) provides X-ray images of the brain's structure to help identify causes of cognitive decline and any signs of shrinkage, fluid, or blood. Magnetic resonance imaging (MRI) provides more detailed brain images, offering insight into structural and vascular damage. Positron Emission Tomography (PET) creates 3D images of the brain, highlighting its structural and metabolic activity, using radioactive technology to trace disease and injury. With images provided by CT, MRI, and PET scans, medical professionals can make more informed decisions about diagnosing Alzheimer's in a patient, determining the current stage of the disease, and selecting appropriate treatment therapies⁠[6]. Laboratory Tests and Biomarkers After all the initial assessments, the tests for an Alzheimer's diagnosis become more extensive, but this is necessary for accurately examining and monitoring a patient's symptoms. Medical professionals may carry out blood tests to check for signs of Alzheimer's disease, though they can usually confirm the diagnosis via a brain scan. Researchers are actively developing blood tests to improve the diagnosis of Alzheimer’s disease, focusing on detecting specific biomarkers linked to the condition. These tests analyze blood samples for proteins such as amyloid beta and tau, which are commonly associated with Alzheimer’s. When these proteins accumulate in the brain, they can enter the bloodstream, providing a potential pathway for early detection. New and more precise biomarker tests are showing encouraging results, offering hope for less invasive, faster, and more accurate diagnostic tools that could transform how Alzheimer’s is diagnosed and managed in the future⁠[7]. Genetic Testing for Alzheimer's There are currently no reliable genetic tests available for those suffering from Alzheimer's disease, so it's not even a feasible option for family members who have relatives with the disorder, which could be genetically transmitted. Researchers are actively developing blood tests to improve the diagnosis of Alzheimer’s disease, focusing on detecting specific biomarkers linked to the condition. These genetic tests for Alzheimer’s disease analyze blood samples for proteins such as amyloid beta and tau, which are commonly associated with the disease. When these proteins accumulate in the brain, they can enter the bloodstream, providing a potential pathway for early detection. New and more precise biomarker tests are showing encouraging results, offering hope for less invasive, faster, and more accurate diagnostic tools that could transform how Alzheimer’s is diagnosed and managed in the future⁠[3]. Differential Diagnosis The symptoms of Alzheimer's disease are often very similar to those of other brain diseases that affect the brain. That's why so much invasive and extensive testing is required to differentiate between symptoms and ensure an accurate Alzheimer's diagnosis. Memory problems are common in individuals who have experienced traumatic brain injury, stroke, or the growth of a tumor. Healthcare professionals use brain scans and blood tests to differentiate these symptoms from those of Alzheimer's. People who have Parkinson's disease also suffer similar cognitive problems to those with Alzheimer's, particularly memory loss, confused thinking, and difficulty performing specific everyday tasks. Distinguishing between the two is integral for appropriate patient care⁠[2]. At times, a patient may have an infection or nutrient deficiency that mimics the early signs of Alzheimer’s disease. Even if these symptoms appear mild, it’s important to investigate them thoroughly to determine if Alzheimer’s is the underlying cause. Additionally, Alzheimer’s is not the only form of dementia. Other types—such as vascular dementia and Lewy body dementia—can produce similar symptoms in the early stages. A primary care physician (PCP) can recommend the appropriate tests to help differentiate between these conditions and ensure an accurate diagnosis⁠[2]. Challenges in Early Diagnosis of Alzheimer's Currently, there is no cure for Alzheimer’s disease, though several medications can help manage its symptoms and slow progression. One of the primary challenges in diagnosing Alzheimer’s is early detection. Biomarker tests show promise for identifying subtle brain changes that may not be visible through standard imaging techniques until the disease has advanced. Accurate identification of early-onset Alzheimer’s would allow individuals to better recognize warning signs and take proactive steps if they are at risk⁠[1]. Improved detection tools, such as brain imaging and blood-based biomarker tests, could streamline diagnosis. Until such technology becomes widely accessible, early consultation with a healthcare provider remains essential at the first sign of symptoms⁠[1]. Why Early Diagnosis of Alzheimer’s Matters Diagnosing Alzheimer's disease is a complex and multifaceted process that involves a variety of thorough evaluations, including cognitive, neurological, and physical assessments, as well as advanced imaging techniques and biomarker testing. Early diagnosis of Alzheimer's is critical, as it allows patients and their families to access vital treatment options and plan for the future while managing symptoms effectively. Understanding the diagnostic process also helps differentiate Alzheimer's from other conditions with similar symptoms, helping to avoid misdiagnosis and ensure appropriate care. Seeking professional medical help at the first signs of cognitive decline is essential. Healthcare providers have the expertise and tools to perform comprehensive evaluations and rule out reversible causes or other disorders. Early intervention preserves cognitive function for longer and empowers patients and their families to make informed decisions about their health and well-being. References Mistur, R., Mosconi, L., De Santi, S., Guzman, M., Li, Y., Tsui, W., et al. (2009). Current challenges for the early detection of Alzheimer's disease: Brain imaging and CSF studies. Journal of Clinical Neurology, 5(4), 153–166. thejcn.com. Accessed October 10 2026. National Institute on Aging. (2022, December 8). How is Alzheimer’s disease diagnosed? National Institute on Aging. National Institute on Aging. Accessed October 10 2026. National Institute on Aging. (2023). Alzheimer’s disease fact sheet. National Institute on Aging; National Institutes of Health. National Institute on Aging. Accessed October 10 2026. Alzheimer’s Association. (2022). Cognitive Assessment. Alzheimer’s Disease and Dementia. Alzheimer’s Association. Accessed October 10 2026. Alzheimer’s Association. (2024). Medical Tests for Diagnosing Alzheimer’s. Alzheimer’s Disease and Dementia; Alzheimer’s Association. Alzheimer’s Association. Accessed October 10 2026. Johnson, K. A., Fox, N. C., Sperling, R. A., & Klunk, W. E. (2012). Brain Imaging in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine, 2(4), a006213–a006213. perspectivesinmedicine.cshlp.org. Accessed October 10 2026. Reynolds, S. (2024, August 13). Accurate blood test for Alzheimer’s disease. National Institutes of Health (NIH). National Institutes of Health. Accessed October 10 2026. Medical Content The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy. About MentalHealth.com MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life. Author Erin L. George MFT Erin L. George, MFT, holds a master's degree in family therapy with a focus on group dynamics in high-risk families. As a court-appointed special advocate for children, she is dedicated to helping families rebuild relationships and improve their mental and behavioral health. Published May 14, 2025 Updated May 14, 2026 Medical Reviewer Morgan Blair, M.A. MA, LPCC Morgan Blair is a licensed therapist, writer and medical reviewer, holding a master’s degree in clinical mental health counseling from Northwestern University. Reviewed May 14, 2025 Related community Medical Conditions Explore the connections between physical health conditions and mental well-being. Table of contentsChoose a section What Is Alzheimer’s disease? Initial Assessment Cognitive and Neuropsychological Tests Physical and Neurological Tests Brain Imaging Techniques Laboratory Tests and Biomarkers Genetic Testing for Alzheimer's Differential Diagnosis Challenges in Early Diagnosis of Alzheimer's Why Early Diagnosis of Alzheimer’s Matters View more","wordCount":2257},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://www.mentalhealth.com/#organization","name":"MentalHealth.com","url":"https://www.mentalhealth.com/","publishingPrinciples":"https://www.mentalhealth.com/publishing/editorial-policy"},{"@type":"WebSite","@id":"https://www.mentalhealth.com/#website","url":"https://www.mentalhealth.com/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://www.mentalhealth.com/#organization"}},{"@type":"BreadcrumbList","@id":"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.mentalhealth.com/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://www.mentalhealth.com/library"},{"@type":"ListItem","position":3,"name":"Assessments & Diagnosis","item":"https://www.mentalhealth.com/library/assessments-diagnosis"},{"@type":"ListItem","position":4,"name":"Diagnosing Alzheimer’s Disease","item":"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing"}]},{"@type":"ImageObject","@id":"https://www.mentalhealth.com/library/diagnosing-alzheimers-neuropsychological-testing#primaryimage","url":"https://www.mentalhealth.com/assets/optimized/fd7ee00d88a6db39c95759b4.webp","contentUrl":"https://www.mentalhealth.com/assets/optimized/fd7ee00d88a6db39c95759b4.webp","width":1200,"height":800,"encodingFormat":"image/webp","caption":"Older friends smile and gesture while sitting together on a sofa."},{"@type":"Person","@id":"https://www.mentalhealth.com/people/erin-george#person","name":"Erin L. 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