{"formatVersion":"1.1","id":"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects","path":"/library/hydroxyzine-uses-dosage-side-effects","url":"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects","title":"Hydroxyzine (Vistaril)","family":"Library detail","description":"Hydroxyzine is an antihistamine medication that is often used in the treatment of anxiety and insomnia. Learn more about it here.","language":"en-US","access":{"audience":"public","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects","wordpressId":"411","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://www.mentalhealth.com/people/naomi-carr#person","name":"Naomi Carr","url":"https://www.mentalhealth.com/people/naomi-carr"}],"reviewer":{"@type":"Person","@id":"https://www.mentalhealth.com/people/jenni-jacobsen#person","name":"Jenni Jacobsen, Ph.D.","url":"https://www.mentalhealth.com/people/jenni-jacobsen"},"dates":{"datePublished":"2023-03-29T12:58:05Z","dateModified":"2025-08-13T12:18:32Z","lastReviewed":"2023-03-29"},"content":{"html":"<nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\"><ol><li><a href=\"https://www.mentalhealth.com/\">Home</a></li><li><a href=\"https://www.mentalhealth.com/library\">Library</a></li><li><a href=\"https://www.mentalhealth.com/library/medications\">Medications</a></li><li><span aria-current=\"page\">Hydroxyzine (Vistaril)</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard=\"\"><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Hydroxyzine (Vistaril)</h1><p class=\"article-inline-credits\"><span class=\"credit-row\"><span>Written by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/naomi-carr\">Naomi Carr</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/jenni-jacobsen\">Jenni Jacobsen, Ph.D.</a></span></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2023-03-29T12:58:05Z\">March 29, 2023</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-08-13T12:18:32Z\">August 13, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Hydroxyzine, also known as Vistaril, is an antihistamine, primarily used in the treatment of allergies and <a href=\"https://www.mentalhealth.com/library/anxiety\" class=\"article-inline-link\" data-context-link=\"355\">anxiety</a>. Always take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on hydroxyzine, as adverse effects can occur.</p></div><figure class=\"article-feature\"><img alt=\"Two men talk together in a bright counseling room.\" decoding=\"async\" height=\"754\" loading=\"eager\" src=\"https://www.mentalhealth.com/assets/optimized/7573f422112508627e09b9ca.webp\" width=\"1200\" srcset=\"/assets/responsive/42787c07a603f00f1405bda4.webp 800w, /assets/optimized/7573f422112508627e09b9ca.webp 1200w\" sizes=\"(max-width: 800px) 100vw, 1200px\"></figure><section aria-labelledby=\"key-takeaways\" class=\"article-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Hydroxyzine is an antihistamine used for anxiety, allergic symptoms, and sedation.</li><li>Hydroxyzine’s sedating effects can cause drowsiness and reduced alertness.</li><li>Alcohol and other central nervous system depressants can intensify sedation, making medication review important.</li></ul></section><h2 id=\"hydroxyzine-brand-names\">Hydroxyzine brand names</h2><ul>\n<li>Vistaril</li>\n</ul><span id=\"what-is-hydroxyzine-prescribed-for-hydroxyzine-is-approved-by-the-us-food-drug-administration-for-use-in-the-treatment-of-anxiety-allergic-reactions-and-as-a-sedative-before-and-after-surgery\" class=\"section-anchor-alias\" data-section-alias=\"what-is-hydroxyzine-prescribed-for\" aria-hidden=\"true\"></span><h2 id=\"what-is-hydroxyzine-prescribed-for\">What is hydroxyzine prescribed for?</h2><p>\nHydroxyzine is approved by the US Food &amp; Drug Administration for use in the treatment of anxiety, allergic reactions, and as a sedative before and after surgery⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>. It can also be prescribed off-label, for a use not approved by the FDA, as a treatment for <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/sleep-disorders\">insomnia</a>, if it is deemed necessary by a medical professional⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#pharmacotherapy-insomnia-primary-care\" data-reference-link=\"\" aria-label=\"Reference 2: Smith, E., Narang, P., Enja, M., &amp; Lippmann, S. (2016). Pharmacotherapy for Insomnia in Primary Care. The Primary Care Companion for CNS Disorders, 18(2), 10.4088/PCC.16br01930. psychiatrist.com. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.\n</p><p>The safety and effectiveness of the long-term use of hydroxyzine for anxiety has not been established, so it is typically prescribed for up to four months. However, if it is deemed necessary for treatment, a doctor can continue to prescribe hydroxyzine for long-term use⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.\n</p><span id=\"how-does-hydroxyzine-work-hydroxyzine-works-by-limiting-the-effects-of-histamine-thereby-reducing-the-prevalence-of-allergic-reactions-such-as-rash-and-itchiness\" class=\"section-anchor-alias\" data-section-alias=\"how-does-hydroxyzine-work\" aria-hidden=\"true\"></span><h2 id=\"how-does-hydroxyzine-work\">How does hydroxyzine work?</h2><p>\nHydroxyzine works by limiting the effects of histamine, thereby reducing the prevalence of allergic reactions such as rash and itchiness⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine\" data-reference-link=\"\" aria-label=\"Reference 3: American Society of Health-System Pharmacists, Inc. (2017). Hydroxyzine. MedlinePlus. MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a></sup>.\nIt also acts as a sedative, by impacting activity in certain parts of the central nervous system, so it can be used as an effective <a href=\"https://www.mentalhealth.com/library/anxiety-treatment\" class=\"article-inline-link\" data-context-link=\"355\">treatment for anxiety</a> and sleep disturbances⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#pubchem-compound-summary-cid-3658-hydroxyzine\" data-reference-link=\"\" aria-label=\"Reference 4: National Center for Biotechnology Information. (2023). PubChem Compound Summary for CID 3658, Hydroxyzine. National Library of Medicine.\" data-reference-number=\"4\">[4]</a><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#value-hydroxyzine-generalized-anxiety-disorder-controlled-double-blind-study\" data-reference-link=\"\" aria-label=\"Reference 5: Ferreri, M., Hantouche, E.G., &amp; Billardon, M. (1994). Value of Hydroxyzine in Generalized Anxiety Disorder: Controlled Double-Blind Study Versus Placebo. L'Encephale, 20(6), 785–791. PubMed.\" data-reference-number=\"5\">[5]</a></sup>.\n</p><span id=\"how-is-hydroxyzine-usually-taken-hydroxyzine-is-available-as-a-capsule-in-25mg-50mg-and-100mg-strengths-and-as-an-oral-suspension-with-25mg-of-hydroxyzine-per-5ml\" class=\"section-anchor-alias\" data-section-alias=\"how-is-hydroxyzine-usually-taken\" aria-hidden=\"true\"></span><h2 id=\"how-is-hydroxyzine-usually-taken\">How is hydroxyzine usually taken?</h2><p>\nHydroxyzine is available as a capsule, in 25mg, 50mg, and 100mg strengths, and as an oral suspension, with 25mg of hydroxyzine per 5ml.\n</p><p>Capsules should be swallowed whole without breaking or crushing. The oral suspension requires shaking prior to administration and directions from the prescribing physician should be followed carefully.</p><p>For the treatment of anxiety, you may be prescribed a dose of 50-100mg, to be taken up to four times per day.</p><p>For the treatment of allergic reactions, you will likely be prescribed 25mg, to be taken 3-4 times per day⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><p>For the treatment of insomnia, you may be prescribed 25-100mg, to be taken in one dose prior to going to bed⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#pharmacotherapy-insomnia-primary-care\" data-reference-link=\"\" aria-label=\"Reference 2: Smith, E., Narang, P., Enja, M., &amp; Lippmann, S. (2016). Pharmacotherapy for Insomnia in Primary Care. The Primary Care Companion for CNS Disorders, 18(2), 10.4088/PCC.16br01930. psychiatrist.com. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.</p><p>As a sedative before or after surgery, you may be given 50-100mg in one dose.</p><p>Hydroxyzine can be prescribed to children in lower doses, dependent on age and weight⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><p>Hydroxyzine can also be prescribed as a PRN, to be taken as and when it is needed. Your doctor will inform you of the maximum amount you should take in a day⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-vistaril\" data-reference-link=\"\" aria-label=\"Reference 6: The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). (2023). Hydroxyzine (Vistaril). NAMI. NAMI. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a></sup>.</p><p>Your doctor will likely monitor your physical and mental health throughout your treatment, and your response to the medication, adjusting your dosage if required.</p><p>\nThis medication should be taken as prescribed, without missing a dose. If a dose is missed, take the medication as soon as possible, or if it is close to the next dosage time, skip the missed dose. Never take double your prescribed dose in one go, as this can have adverse effects and may increase the risk of side effects.\n</p><span id=\"how-long-does-hydroxyzine-stay-in-your-system-after-you-begin-taking-hydroxyzine-you-may-begin-to-feel-the-effects-within-30-minutes-of-your-first-dose\" class=\"section-anchor-alias\" data-section-alias=\"how-long-does-hydroxyzine-stay-in-your-system\" aria-hidden=\"true\"></span><h2 id=\"how-long-does-hydroxyzine-stay-in-your-system\">How long does hydroxyzine stay in your system?</h2><p>\nAfter you begin taking hydroxyzine, you may begin to feel the effects within 30 minutes of your first dose⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.\nWhen you stop taking hydroxyzine, the medication will entirely leave your system within 2 days⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#pubchem-compound-summary-cid-3658-hydroxyzine\" data-reference-link=\"\" aria-label=\"Reference 4: National Center for Biotechnology Information. (2023). PubChem Compound Summary for CID 3658, Hydroxyzine. National Library of Medicine.\" data-reference-number=\"4\">[4]</a></sup>.\n</p><span id=\"hydroxyzine-side-effects-when-you-begin-taking-a-new-medication-you-may-experience-some-common-side-effects-they-will-likely-reduce-within-the-first-week-or-two-but-if-they-continue-or-become-problematic-consult-with-your-doctor-as-you-may-need-a-reduced-dose-or-a-change-of-medication-common-side-effects-of-hydroxyzine-include\" class=\"section-anchor-alias\" data-section-alias=\"hydroxyzine-side-effects\" aria-hidden=\"true\"></span><h2 id=\"hydroxyzine-side-effects\">Hydroxyzine side effects</h2><p>\nWhen you begin taking a new medication, you may experience some common side effects. They will likely reduce within the first week or two, but if they continue or become problematic, consult with your doctor, as you may need a reduced dose or a change of medication.\nCommon side effects of hydroxyzine include⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine\" data-reference-link=\"\" aria-label=\"Reference 3: American Society of Health-System Pharmacists, Inc. (2017). Hydroxyzine. MedlinePlus. MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-vistaril\" data-reference-link=\"\" aria-label=\"Reference 6: The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). (2023). Hydroxyzine (Vistaril). NAMI. NAMI. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a></sup>:\n</p><ul>\n<li>Dry mouth</li>\n<li>Drowsiness</li>\n<li>Dizziness</li>\n<li>Headache</li>\n<li>Confusion</li>\n<li>Blurred vision</li>\n</ul><p>\nSerious side effects of hydroxyzine are less common but may still occur. Contact your doctor immediately if you experience any of the following:\n</p><ul>\n<li>Tremors or shaking</li>\n<li>Seizures</li>\n<li>Rash or blisters</li>\n<li>Swelling of the face or mouth</li>\n<li>Fever</li>\n<li>Increased or irregular heart rhythm</li>\n<li>Hallucinations</li>\n</ul><p>\nThis is not a complete list of possible side effects of hydroxyzine. Always seek medical attention if you experience any side effects that you think may be due to your use of this medication.\n</p><span id=\"hydroxyzine-precautions-never-take-hydroxyzine-without-proper-medical-advice-it-is-important-that-your-doctor-is-aware-of-any-past-or-present-mental-health-conditions-you-have-experienced-to-enable-safe-monitoring-of-your-condition-while-on-this-medication-or-to-decide-if-it-is-safe-for-you\" class=\"section-anchor-alias\" data-section-alias=\"hydroxyzine-precautions\" aria-hidden=\"true\"></span><h2 id=\"hydroxyzine-precautions\">Hydroxyzine precautions</h2><p>\nNever take hydroxyzine without proper medical advice. It is important that your doctor is aware of any past or present mental health conditions you have experienced, to enable safe monitoring of your condition while on this medication, or to decide if it is safe for you.\n</p><p>Discuss with your doctor all your past and present physical health conditions, as they may impact your ability to take this medication safely.</p><p>Ensure you tell your doctor if you have had a serious heart condition as this medication may not be safe for you to take, or you may require a reduced dose and more frequent monitoring of your physical health⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine\" data-reference-link=\"\" aria-label=\"Reference 3: American Society of Health-System Pharmacists, Inc. (2017). Hydroxyzine. MedlinePlus. MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a></sup>.</p><p>Discuss with your doctor if you are pregnant or planning to become pregnant, as there is research to suggest that it may cause fetal abnormalities if taken in the first trimester, although it may be safe in the second and third trimester⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-vistaril\" data-reference-link=\"\" aria-label=\"Reference 6: The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). (2023). Hydroxyzine (Vistaril). NAMI. NAMI. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#pregnancy-therapeutic-dilemma\" data-reference-link=\"\" aria-label=\"Reference 7: Brzezińska-Wcisło, L., Zbiciak-Nylec, M., Wcisło-Dziadecka, D., &amp; Salwowska, N. (2017). Pregnancy: A Therapeutic Dilemma. Postepy dermatologii i alergologii, 34(5), 433–438. termedia.pl. Accessed October 10 2026.\" data-reference-number=\"7\">[7]</a></sup>. Your doctor will inform you of the risks so that you can make an informed decision about your treatment.</p><p>Inform your doctor if you are breastfeeding. Currently, research is not clear about how much hydroxyzine is excreted in breast milk, so it is recommended not to take this medication as it may cause harm to your baby⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><p>This medication can cause drowsiness and sedation, so it is important to avoid driving until you are aware of how hydroxyzine affects you and it is safe to do so.</p><p>\nTell your doctor about all medications you are currently taking, or plan to take (including vitamins and dietary supplements), as they may cause adverse reactions.\n</p><span id=\"hydroxyzine-interactions-due-to-its-sedating-effects-it-is-recommended-to-avoid-or-limit-the-dosage-of-any-medications-or-substances-that-affect-the-central-nervous-system-such-as-other-sedatives-opiates-barbiturates-and-alcohol-combining-hydroxyzine-with-any-of-these-substances-can-increase-the-risk-of-serious-side-effects-and-oversedation\" class=\"section-anchor-alias\" data-section-alias=\"hydroxyzine-interactions\" aria-hidden=\"true\"></span><h2 id=\"hydroxyzine-interactions\">Hydroxyzine interactions</h2><p>\nDue to its sedating effects, it is recommended to avoid or limit the dosage of any medications or substances that affect the central nervous system, such as other sedatives, opiates, barbiturates, and alcohol. Combining hydroxyzine with any of these substances can increase the risk of serious side effects and oversedation⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.\n</p><p>Other medications may interact with hydroxyzine, potentially increasing the risk of side effects or decreasing the effectiveness of your medication, such as other antihistamines, certain heart disease medications, some antibiotics, anticonvulsants, and mental health medications including some <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/antidepressants\">antidepressants</a>, <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/antipsychotics\">antipsychotics</a>, and <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/anxiolytics\">anti-anxiety medications</a>⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine\" data-reference-link=\"\" aria-label=\"Reference 3: American Society of Health-System Pharmacists, Inc. (2017). Hydroxyzine. MedlinePlus. MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a></sup>.</p><p>\nAlways discuss your medications with your doctor before starting a new treatment.\n</p><span id=\"hydroxyzine-storage-always-keep-all-medications-out-of-reach-of-children\" class=\"section-anchor-alias\" data-section-alias=\"hydroxyzine-storage\" aria-hidden=\"true\"></span><h2 id=\"hydroxyzine-storage\">Hydroxyzine storage</h2><p>\nAlways keep all medications out of reach of children.\n</p><p>Store duloxetine in its original packaging, in airtight containers, and at room temperature (68°F to 77°F).</p><p>\nIf you need to dispose of medication that is out of date or no longer needed, contact a health care professional to ensure it is disposed of appropriately. Never flush medications down the toilet or throw them in the trash, as this can create unnecessary risks.\n</p><span id=\"what-to-do-if-you-overdose-on-hydroxyzine-if-you-overdose-on-hydroxyzine-call-a-medical-professional-or-poison-control-at-1-800-222-1222-or-in-case-of-an-emergency-call-911-symptoms-of-a-hydroxyzine-overdose-include-oversedation-nausea-or-vomiting-dizziness-and-seizure\" class=\"section-anchor-alias\" data-section-alias=\"what-to-do-if-you-overdose-on-hydroxyzine\" aria-hidden=\"true\"></span><h2 id=\"what-to-do-if-you-overdose-on-hydroxyzine\">What to do if you overdose on hydroxyzine</h2><p>\nIf you overdose on hydroxyzine, call a medical professional, or Poison Control at 1-800-222-1222, or in case of an emergency, call 911. Symptoms of a hydroxyzine overdose include oversedation, nausea or vomiting, dizziness, and seizure.\n</p><h2 id=\"frequently-asked-questions-about-hydroxyzine\">Frequently asked questions about hydroxyzine</h2><h3 id=\"if-i-m-no-longer-taking-hydroxyzine-can-i-drink-alcohol-alcohol-should-be-avoided-while-taking-hydroxyzine-as-it-can-increase-the-sedating-effects-of-the-medication-and-increase-the-risk-of-side-effects\">If I’m no longer taking hydroxyzine, can I drink alcohol?</h3><p>\nAlcohol should be avoided while taking hydroxyzine, as it can increase the sedating effects of the medication and increase the risk of side effects⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" data-reference-link=\"\" aria-label=\"Reference 1: Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>. </p><p>If hydroxyzine treatment is discontinued, it is safe to recommence drinking alcohol once the medication has fully left your system, and in safe amounts.\nConsult with your doctor about drinking alcohol following hydroxyzine treatment, as they may make recommendations depending on your condition or other medications that you are taking.\n</p><h3 id=\"does-hydroxyzine-affect-sleep-hydroxyzine-has-a-sedating-effect-and-can-be-used-off-label-in-the-treatment-of-insomnia-clinical-studies-have-found-that-it-can-reduce-sleep-disturbances-and-improve-quality-of-sleep\">Does hydroxyzine affect sleep?</h3><p>\nHydroxyzine has a sedating effect and can be used off-label in the treatment of insomnia. Clinical studies have found that it can reduce sleep disturbances and improve quality of sleep⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#pharmacotherapy-insomnia-primary-care\" data-reference-link=\"\" aria-label=\"Reference 2: Smith, E., Narang, P., Enja, M., &amp; Lippmann, S. (2016). Pharmacotherapy for Insomnia in Primary Care. The Primary Care Companion for CNS Disorders, 18(2), 10.4088/PCC.16br01930. psychiatrist.com. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#selecting-pharmacotherapy-regimen-patients-chronic-insomnia\" data-reference-link=\"\" aria-label=\"Reference 8: Hassinger, A.B., Bletnisky, N., Dudekula, R., &amp; El-Solh, A.A. (2020). Selecting a Pharmacotherapy Regimen for Patients with Chronic Insomnia. Expert Opinion on Pharmacotherapy, 21(9), 1035–1043. Taylor &amp; Francis.\" data-reference-number=\"8\">[8]</a></sup>.\n</p><p>If you are concerned about the sedating effects of this medication, you may wish to consult with your doctor about alternative therapy or medication for your condition.</p><section aria-label=\"Subject matter expert\" class=\"article-expert article-expert-inline\" data-expert-kind=\"related\" data-expert-layout=\"standard\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"card-identity-photo\" aria-label=\"Leila Khurshid, Pharm.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"64\" decoding=\"async\"></a><h2><a href=\"https://www.mentalhealth.com/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"quiet-button\">View profile</a></section></article><div class=\"article-endmatter\"><section class=\"article-sources\" data-reference-list=\"\" data-reference-style=\"author-date-title-source\" data-source-references=\"\" id=\"references\"><h2 id=\"references-2\">References</h2><ol><li id=\"vistaril-hydroxyzine-pamoate-capsules-oral-suspension\" value=\"1\" data-reference-number=\"1\" data-reference-format=\"393\">Pfizer Inc. (2014). <em class=\"reference-title\">Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension.</em> Access Data FDA. <a href=\"https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/011459s048%2C011795s025lbl.pdf?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">U.S. Food and Drug Administration</a>. Accessed October 10 2026.</li><li id=\"pharmacotherapy-insomnia-primary-care\" value=\"2\" data-reference-number=\"2\" data-reference-format=\"393\">Smith, E., Narang, P., Enja, M., &amp; Lippmann, S. (2016). <em class=\"reference-title\">Pharmacotherapy for Insomnia in Primary Care.</em> The Primary Care Companion for CNS Disorders, 18(2), 10.4088/PCC.16br01930. <a href=\"https://www.psychiatrist.com/pcc/pharmacotherapy-for-insomnia/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">psychiatrist.com</a>. Accessed October 10 2026.</li><li id=\"hydroxyzine\" value=\"3\" data-reference-number=\"3\" data-reference-format=\"393\">American Society of Health-System Pharmacists, Inc. (2017). <em class=\"reference-title\">Hydroxyzine.</em> MedlinePlus. <a href=\"https://medlineplus.gov/druginfo/meds/a682866.html?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">MedlinePlus</a>. Accessed October 10 2026.</li><li id=\"pubchem-compound-summary-cid-3658-hydroxyzine\" value=\"4\" data-reference-number=\"4\" data-reference-format=\"393\">National Center for Biotechnology Information. (2023). <em class=\"reference-title\">PubChem Compound Summary for CID 3658, Hydroxyzine.</em> <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyzine?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>.</li><li id=\"value-hydroxyzine-generalized-anxiety-disorder-controlled-double-blind-study\" value=\"5\" data-reference-number=\"5\" data-reference-format=\"393\">Ferreri, M., Hantouche, E.G., &amp; Billardon, M. (1994). <em class=\"reference-title\">Value of Hydroxyzine in Generalized Anxiety Disorder: Controlled Double-Blind Study Versus Placebo.</em> L'Encephale, 20(6), 785–791. <a href=\"https://pubmed.ncbi.nlm.nih.gov/7875114/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>.</li><li id=\"hydroxyzine-vistaril\" value=\"6\" data-reference-number=\"6\" data-reference-format=\"393\">The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). (2023). <em class=\"reference-title\">Hydroxyzine (Vistaril).</em> NAMI. <a href=\"https://www.nami.org/treatments-and-approaches/mental-health-medications/types-of-medication/hydroxyzine-(vistaril/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">NAMI</a>. Accessed October 10 2026.</li><li id=\"pregnancy-therapeutic-dilemma\" value=\"7\" data-reference-number=\"7\" data-reference-format=\"393\">Brzezińska-Wcisło, L., Zbiciak-Nylec, M., Wcisło-Dziadecka, D., &amp; Salwowska, N. (2017). <em class=\"reference-title\">Pregnancy: A Therapeutic Dilemma.</em> Postepy dermatologii i alergologii, 34(5), 433–438. <a href=\"https://www.termedia.pl/Pregnancy-a-therapeutic-dilemma,7,30901,0,1.html?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">termedia.pl</a>. Accessed October 10 2026.</li><li id=\"selecting-pharmacotherapy-regimen-patients-chronic-insomnia\" value=\"8\" data-reference-number=\"8\" data-reference-format=\"393\">Hassinger, A.B., Bletnisky, N., Dudekula, R., &amp; El-Solh, A.A. (2020). <em class=\"reference-title\">Selecting a Pharmacotherapy Regimen for Patients with Chronic Insomnia.</em> Expert Opinion on Pharmacotherapy, 21(9), 1035–1043. <a href=\"https://www.tandfonline.com/doi/full/10.1080/14656566.2020.1743265?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-hydroxyzine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">Taylor &amp; Francis</a>.</li></ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://www.mentalhealth.com/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://www.mentalhealth.com/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/naomi-carr\" class=\"card-identity-photo\" aria-label=\"Naomi Carr\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/47686b37ff1465ff6711c0b5.jpg\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Author</p><h3 id=\"naomi-carr\"><a href=\"https://www.mentalhealth.com/people/naomi-carr\">Naomi Carr</a></h3><p class=\"article-bio-credentials\">Writer</p><p>Naomi Carr is a writer with a background in English Literature from Oxford Brookes University.</p><dl><div><dt>Published</dt><dd><time datetime=\"2023-03-29T12:58:05Z\">March 29, 2023</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-08-13T12:18:32Z\">August 13, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/jenni-jacobsen\" class=\"card-identity-photo\" aria-label=\"Jenni Jacobsen, Ph.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/4f4e4293be2246dfe2e00d7c.jpg\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"jenni-jacobsen-ph-d\"><a href=\"https://www.mentalhealth.com/people/jenni-jacobsen\">Jenni Jacobsen, Ph.D.</a></h3><p class=\"article-bio-credentials\">Ph.D., LSW, MSW</p><p>Jenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2023-03-29\">March 29, 2023</time></dd></div></dl></div></section></div></section><section aria-label=\"Related community\" class=\"article-topic-community article-topic-community-end\"><a href=\"https://www.mentalhealth.com/community/medications\" class=\"card-identity-photo\" aria-label=\"Medications\"><img alt=\"\" class=\"topic-community-banner\" height=\"675\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/f5e91a4297495afdb6431ec9.webp\" width=\"1199\" decoding=\"async\"></a><p class=\"topic-community-label\">Related community</p><h2><a href=\"https://www.mentalhealth.com/community/medications\">Medications</a></h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p></section></div></div><aside aria-label=\"Article navigation and related information\" class=\"article-sidebar\" data-bounded-rail=\"\" tabindex=\"0\"><details class=\"article-contents\" data-expanded=\"false\" data-scrolled-past=\"false\" data-section-preview=\"3\" open=\"\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a aria-label=\"Hydroxyzine brand names\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-brand-names\" title=\"Hydroxyzine brand names\">Hydroxyzine brand names</a></li><li><a aria-label=\"What is hydroxyzine prescribed for?\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#what-is-hydroxyzine-prescribed-for\" title=\"What is hydroxyzine prescribed for?\">What is hydroxyzine prescribed for?</a></li><li><a aria-label=\"How does hydroxyzine work?\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#how-does-hydroxyzine-work\" title=\"How does hydroxyzine work?\">How does hydroxyzine work?</a></li><li><a aria-label=\"How is hydroxyzine usually taken?\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#how-is-hydroxyzine-usually-taken\" title=\"How is hydroxyzine usually taken?\">How is hydroxyzine usually taken?</a></li><li><a aria-label=\"How long does hydroxyzine stay in your system?\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#how-long-does-hydroxyzine-stay-in-your-system\" title=\"How long does hydroxyzine stay in your system?\">How long does hydroxyzine stay in your system?</a></li><li><a aria-label=\"Hydroxyzine side effects\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-side-effects\" title=\"Hydroxyzine side effects\">Hydroxyzine side effects</a></li><li><a aria-label=\"Hydroxyzine precautions\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-precautions\" title=\"Hydroxyzine precautions\">Hydroxyzine precautions</a></li><li><a aria-label=\"Hydroxyzine interactions\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-interactions\" title=\"Hydroxyzine interactions\">Hydroxyzine interactions</a></li><li><a aria-label=\"Hydroxyzine storage\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#hydroxyzine-storage\" title=\"Hydroxyzine storage\">Hydroxyzine storage</a></li><li><a aria-label=\"What to do if you overdose on hydroxyzine\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#what-to-do-if-you-overdose-on-hydroxyzine\" title=\"What to do if you overdose on hydroxyzine\">What to do if you overdose on hydroxyzine</a></li><li><a aria-label=\"Frequently asked questions about hydroxyzine\" href=\"https://www.mentalhealth.com/library/hydroxyzine-uses-dosage-side-effects#frequently-asked-questions-about-hydroxyzine\" title=\"Frequently asked questions about hydroxyzine\">Frequently asked questions about hydroxyzine</a></li></ol><button aria-controls=\"article-section-list\" aria-expanded=\"false\" class=\"article-sections-toggle\" data-sections-toggle=\"\" type=\"button\">View more</button></nav></details></aside></div></div></div>","text":"Home Library Medications Hydroxyzine (Vistaril) Hydroxyzine (Vistaril) Written by Naomi CarrMedically reviewed by Jenni Jacobsen, Ph.D. Published on March 29, 2023 · Updated on August 13, 2025 Hydroxyzine, also known as Vistaril, is an antihistamine, primarily used in the treatment of allergies and anxiety. Always take this medication exactly as prescribed and consult with your doctor before starting any other medication (prescribed or over the counter) while on hydroxyzine, as adverse effects can occur. Key takeaways Hydroxyzine is an antihistamine used for anxiety, allergic symptoms, and sedation. Hydroxyzine’s sedating effects can cause drowsiness and reduced alertness. Alcohol and other central nervous system depressants can intensify sedation, making medication review important. Hydroxyzine brand names Vistaril What is hydroxyzine prescribed for? Hydroxyzine is approved by the US Food & Drug Administration for use in the treatment of anxiety, allergic reactions, and as a sedative before and after surgery⁠[1]. It can also be prescribed off-label, for a use not approved by the FDA, as a treatment for insomnia, if it is deemed necessary by a medical professional⁠[2]. The safety and effectiveness of the long-term use of hydroxyzine for anxiety has not been established, so it is typically prescribed for up to four months. However, if it is deemed necessary for treatment, a doctor can continue to prescribe hydroxyzine for long-term use⁠[1]. How does hydroxyzine work? Hydroxyzine works by limiting the effects of histamine, thereby reducing the prevalence of allergic reactions such as rash and itchiness⁠[3]. It also acts as a sedative, by impacting activity in certain parts of the central nervous system, so it can be used as an effective treatment for anxiety and sleep disturbances⁠[4][5]. How is hydroxyzine usually taken? Hydroxyzine is available as a capsule, in 25mg, 50mg, and 100mg strengths, and as an oral suspension, with 25mg of hydroxyzine per 5ml. Capsules should be swallowed whole without breaking or crushing. The oral suspension requires shaking prior to administration and directions from the prescribing physician should be followed carefully. For the treatment of anxiety, you may be prescribed a dose of 50-100mg, to be taken up to four times per day. For the treatment of allergic reactions, you will likely be prescribed 25mg, to be taken 3-4 times per day⁠[1]. For the treatment of insomnia, you may be prescribed 25-100mg, to be taken in one dose prior to going to bed⁠[2]. As a sedative before or after surgery, you may be given 50-100mg in one dose. Hydroxyzine can be prescribed to children in lower doses, dependent on age and weight⁠[1]. Hydroxyzine can also be prescribed as a PRN, to be taken as and when it is needed. Your doctor will inform you of the maximum amount you should take in a day⁠[6]. Your doctor will likely monitor your physical and mental health throughout your treatment, and your response to the medication, adjusting your dosage if required. This medication should be taken as prescribed, without missing a dose. If a dose is missed, take the medication as soon as possible, or if it is close to the next dosage time, skip the missed dose. Never take double your prescribed dose in one go, as this can have adverse effects and may increase the risk of side effects. How long does hydroxyzine stay in your system? After you begin taking hydroxyzine, you may begin to feel the effects within 30 minutes of your first dose⁠[1]. When you stop taking hydroxyzine, the medication will entirely leave your system within 2 days⁠[4]. Hydroxyzine side effects When you begin taking a new medication, you may experience some common side effects. They will likely reduce within the first week or two, but if they continue or become problematic, consult with your doctor, as you may need a reduced dose or a change of medication. Common side effects of hydroxyzine include⁠[3][6]: Dry mouth Drowsiness Dizziness Headache Confusion Blurred vision Serious side effects of hydroxyzine are less common but may still occur. Contact your doctor immediately if you experience any of the following: Tremors or shaking Seizures Rash or blisters Swelling of the face or mouth Fever Increased or irregular heart rhythm Hallucinations This is not a complete list of possible side effects of hydroxyzine. Always seek medical attention if you experience any side effects that you think may be due to your use of this medication. Hydroxyzine precautions Never take hydroxyzine without proper medical advice. It is important that your doctor is aware of any past or present mental health conditions you have experienced, to enable safe monitoring of your condition while on this medication, or to decide if it is safe for you. Discuss with your doctor all your past and present physical health conditions, as they may impact your ability to take this medication safely. Ensure you tell your doctor if you have had a serious heart condition as this medication may not be safe for you to take, or you may require a reduced dose and more frequent monitoring of your physical health⁠[3]. Discuss with your doctor if you are pregnant or planning to become pregnant, as there is research to suggest that it may cause fetal abnormalities if taken in the first trimester, although it may be safe in the second and third trimester⁠[6][7]. Your doctor will inform you of the risks so that you can make an informed decision about your treatment. Inform your doctor if you are breastfeeding. Currently, research is not clear about how much hydroxyzine is excreted in breast milk, so it is recommended not to take this medication as it may cause harm to your baby⁠[1]. This medication can cause drowsiness and sedation, so it is important to avoid driving until you are aware of how hydroxyzine affects you and it is safe to do so. Tell your doctor about all medications you are currently taking, or plan to take (including vitamins and dietary supplements), as they may cause adverse reactions. Hydroxyzine interactions Due to its sedating effects, it is recommended to avoid or limit the dosage of any medications or substances that affect the central nervous system, such as other sedatives, opiates, barbiturates, and alcohol. Combining hydroxyzine with any of these substances can increase the risk of serious side effects and oversedation⁠[1]. Other medications may interact with hydroxyzine, potentially increasing the risk of side effects or decreasing the effectiveness of your medication, such as other antihistamines, certain heart disease medications, some antibiotics, anticonvulsants, and mental health medications including some antidepressants, antipsychotics, and anti-anxiety medications⁠[3]. Always discuss your medications with your doctor before starting a new treatment. Hydroxyzine storage Always keep all medications out of reach of children. Store duloxetine in its original packaging, in airtight containers, and at room temperature (68°F to 77°F). If you need to dispose of medication that is out of date or no longer needed, contact a health care professional to ensure it is disposed of appropriately. Never flush medications down the toilet or throw them in the trash, as this can create unnecessary risks. What to do if you overdose on hydroxyzine If you overdose on hydroxyzine, call a medical professional, or Poison Control at 1-800-222-1222, or in case of an emergency, call 911. Symptoms of a hydroxyzine overdose include oversedation, nausea or vomiting, dizziness, and seizure. Frequently asked questions about hydroxyzine If I’m no longer taking hydroxyzine, can I drink alcohol? Alcohol should be avoided while taking hydroxyzine, as it can increase the sedating effects of the medication and increase the risk of side effects⁠[1]. If hydroxyzine treatment is discontinued, it is safe to recommence drinking alcohol once the medication has fully left your system, and in safe amounts. Consult with your doctor about drinking alcohol following hydroxyzine treatment, as they may make recommendations depending on your condition or other medications that you are taking. Does hydroxyzine affect sleep? Hydroxyzine has a sedating effect and can be used off-label in the treatment of insomnia. Clinical studies have found that it can reduce sleep disturbances and improve quality of sleep⁠[2][8]. If you are concerned about the sedating effects of this medication, you may wish to consult with your doctor about alternative therapy or medication for your condition. Subject matter expert Leila Khurshid, Pharm.D. Clinical pharmacy and medication View profile References Pfizer Inc. (2014). Vistaril (Hydroxyzine Pamoate) Capsules and Oral Suspension. Access Data FDA. U.S. Food and Drug Administration. Accessed October 10 2026. Smith, E., Narang, P., Enja, M., & Lippmann, S. (2016). Pharmacotherapy for Insomnia in Primary Care. The Primary Care Companion for CNS Disorders, 18(2), 10.4088/PCC.16br01930. psychiatrist.com. Accessed October 10 2026. American Society of Health-System Pharmacists, Inc. (2017). Hydroxyzine. MedlinePlus. MedlinePlus. Accessed October 10 2026. National Center for Biotechnology Information. (2023). PubChem Compound Summary for CID 3658, Hydroxyzine. National Library of Medicine. Ferreri, M., Hantouche, E.G., & Billardon, M. (1994). Value of Hydroxyzine in Generalized Anxiety Disorder: Controlled Double-Blind Study Versus Placebo. L'Encephale, 20(6), 785–791. PubMed. The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). (2023). Hydroxyzine (Vistaril). NAMI. NAMI. Accessed October 10 2026. Brzezińska-Wcisło, L., Zbiciak-Nylec, M., Wcisło-Dziadecka, D., & Salwowska, N. (2017). Pregnancy: A Therapeutic Dilemma. Postepy dermatologii i alergologii, 34(5), 433–438. termedia.pl. Accessed October 10 2026. Hassinger, A.B., Bletnisky, N., Dudekula, R., & El-Solh, A.A. (2020). Selecting a Pharmacotherapy Regimen for Patients with Chronic Insomnia. Expert Opinion on Pharmacotherapy, 21(9), 1035–1043. Taylor & Francis. Medical Content The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy. About MentalHealth.com MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life. Author Naomi Carr Writer Naomi Carr is a writer with a background in English Literature from Oxford Brookes University. Published March 29, 2023 Updated August 13, 2025 Medical Reviewer Jenni Jacobsen, Ph.D. Ph.D., LSW, MSW Jenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology. Reviewed March 29, 2023 Related community Medications Explore questions and perspectives about psychiatric medications and the treatment experience. Table of contentsChoose a section Hydroxyzine brand names What is hydroxyzine prescribed for? How does hydroxyzine work? How is hydroxyzine usually taken? How long does hydroxyzine stay in your system? 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