{"formatVersion":"1.1","id":"https://www.mentalhealth.com/library/opioid-use-disorder","path":"/library/opioid-use-disorder","url":"https://www.mentalhealth.com/library/opioid-use-disorder","title":"Opioid Use Disorder","family":"Library detail","description":"Opioid use disorder refers to a person's inability to control their use of the substance. Severe use disorders often go on to be classed as addictions.","language":"en-US","access":{"audience":"public","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/opioid-use-disorder","wordpressId":"197","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://www.mentalhealth.com/people/erin-rodgers#person","name":"Erin Rodgers","url":"https://www.mentalhealth.com/people/erin-rodgers"}],"reviewer":{"@type":"Person","@id":"https://www.mentalhealth.com/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://www.mentalhealth.com/people/leila-khurshid"},"dates":{"datePublished":"2022-11-22T19:00:00Z","dateModified":"2025-07-31T21:35:47Z","lastReviewed":"2022-11-23"},"content":{"html":"<nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\"><ol><li><a href=\"https://www.mentalhealth.com/\">Home</a></li><li><a href=\"https://www.mentalhealth.com/library\">Library</a></li><li><a href=\"https://www.mentalhealth.com/library/substance-use-disorders\">Substance Use Disorders</a></li><li><span aria-current=\"page\">Opioid Use Disorder</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard=\"\"><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Opioid Use Disorder</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/erin-rodgers\"><img alt=\"\" height=\"22\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/227a39018d558e54bf0af4a6.webp\" width=\"22\" decoding=\"async\">Erin Rodgers</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/leila-khurshid\"><img alt=\"\" height=\"22\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"22\" decoding=\"async\">Leila Khurshid, Pharm.D.</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-07-31T21:35:47Z\">July 31, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Opioid use disorder is developed when a class of drugs called <a href=\"https://www.mentalhealth.com/library/opioids\" class=\"article-inline-link\" data-context-link=\"358\">opioids</a>, or opiates, are misused. They are highly addictive, and their misuse can lead to serious health complications, but dependence can be treated by detoxification assisted by medication and therapy.</p></div><figure class=\"article-feature\"><img alt=\"People lean toward one another during a small group conversation.\" decoding=\"async\" height=\"675\" loading=\"eager\" src=\"https://www.mentalhealth.com/assets/optimized/6731c1b4f759cd691a05e238.webp\" width=\"1200\" srcset=\"/assets/responsive/0f1309cc04080650561d60fc.webp 800w, /assets/optimized/6731c1b4f759cd691a05e238.webp 1200w\" sizes=\"(max-width: 800px) 100vw, 1200px\"></figure><section aria-labelledby=\"key-takeaways\" class=\"article-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Opioid use disorder can involve compulsive use of prescription or illicit opioids despite harmful consequences.</li><li>Dependence, withdrawal, health complications, and disruptions to daily life can accompany problematic opioid use.</li><li>Medication and therapy support treatment, while supervised prescribing and secure medication storage can reduce preventable risks.</li></ul></section><span id=\"what-are-opioids-opioids-are-often-prescribed-as-painkillers-but-some-street-drugs-also-come-under-this-category-traditionally-derived-from-the-opium-poppy-some-opioids-are-now-made-synthetically-common-examples-of-opioids-include\" class=\"section-anchor-alias\" data-section-alias=\"what-are-opioids\" aria-hidden=\"true\"></span><h2 id=\"what-are-opioids\">What are opioids?</h2><p>\nOpioids are often prescribed as painkillers, but some street drugs also come under this category. Traditionally derived from the opium poppy, some opioids are now made synthetically. Common examples of opioids include:\n</p><ul>\n<li>Morphine</li>\n<li>Codeine</li>\n<li>Oxycodone</li>\n<li>Fentanyl</li>\n<li>Tramadol</li>\n<li>Heroin</li>\n</ul><p>\nAside from relieving pain and <a href=\"https://www.mentalhealth.com/library/anxiety\" class=\"article-inline-link\" data-context-link=\"355\">anxiety</a>, they can also affect the brain by creating a feeling of numbness and euphoria, often experienced as a ‘high.’\n</p><span id=\"what-is-opioid-dependence-opioid-use-disorder-is-the-consequence-of-using-opioids-beyond-their-intended-purpose-often-leading-to-both-physical-and-mental-addiction-opioid-addiction-can-stem-from-the-misuse-of-prescription-drugs-leading-to-cravings-a-harmful-preoccupation-with-sourcing-more-and-intense-withdrawal-symptoms-if-unable-to-do-so-over-time-increased-resilience-often-leads-to-increased-dosage-which-can-severely-impact-the-person-s-physical-health-mental-health-and-social-well-being\" class=\"section-anchor-alias\" data-section-alias=\"what-is-opioid-dependence\" aria-hidden=\"true\"></span><h2 id=\"what-is-opioid-dependence\">What is opioid dependence?</h2><p>\nOpioid use disorder is the consequence of using opioids beyond their intended purpose, often leading to both physical and mental addiction. Opioid addiction can stem from the misuse of prescription drugs, leading to cravings, a harmful preoccupation with sourcing more, and intense withdrawal symptoms if unable to do so.\n</p><p>Over time, increased resilience often leads to increased dosage, which can severely impact the person’s physical health, mental health, and social well-being.\n</p><span id=\"how-common-is-opioid-dependence-the-opioid-crisis-was-declared-a-nationwide-public-health-emergency-on-october-27-2017-around-3-million-people-in-the-united-states-are-living-with-opioid-use-disorder-or-have-experienced-it-in-the-past\" class=\"section-anchor-alias\" data-section-alias=\"how-common-is-opioid-dependence\" aria-hidden=\"true\"></span><h2 id=\"how-common-is-opioid-dependence\">How common is opioid dependence?</h2><p>\nThe opioid crisis was declared a nationwide Public Health Emergency on October 27, 2017. Around 3 million people in the United States are living with opioid use disorder or have experienced it in the past⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#opioid-addiction\" data-reference-link=\"\" aria-label=\"Reference 3: Azadfard, M., Huecker, M. R., &amp; Leaming, J. M. (2022). Opioid Addiction. In StatPearls [Internet]. StatPearls Publishing. National Library of Medicine.\" data-reference-number=\"3\">[3]</a></sup>.This has led to a dramatic rise in the number of opioid overdose cases, primarily due to an influx of fentanyl on the streets, a synthetic opioid that is 50 times stronger than <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/heroin-addiction-signs-symptoms-effects-help\">heroin</a>. </p>\n<p>The risk of overdose from fentanyl is far greater than with other opioids and will often end in death without intervention.\nAccording to the American Medical Association (AMA), between 3 - 19% of people who use prescribed pain medications develop an <a href=\"https://www.mentalhealth.com/library/addiction\" class=\"article-inline-link\" data-context-link=\"355\">addiction</a>, and about 45% of heroin addictions originate from an addiction to prescribed opioids⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#prescription-opioid-epidemic-know-facts\" data-reference-link=\"\" aria-label=\"Reference 4: American Medical Association Alliance. (2019). Prescription opioid epidemic: Know the facts [White paper]. American Medical Association Alliance. Original online source unavailable; citation details retained.\" data-reference-number=\"4\">[4]</a></sup>.\n</p><span id=\"signs-and-symptoms-of-opioid-dependence-opioid-dependence-and-addiction-can-manifest-in-various-physical-and-mental-symptoms-and-behavioral-changes-it-is-a-chronic-lifelong-disorder-that-can-have-serious-consequences-including-death-once-an-addiction-has-formed-abstinence-from-opioids-can-cause-severe-withdrawal-symptoms-which-can-lead-to-further-drug-use\" class=\"section-anchor-alias\" data-section-alias=\"signs-and-symptoms-of-opioid-dependence\" aria-hidden=\"true\"></span><h2 id=\"signs-and-symptoms-of-opioid-dependence\">Signs and symptoms of opioid dependence</h2><p>\nOpioid dependence and addiction can manifest in various physical and mental symptoms and behavioral changes. It is a chronic, lifelong disorder that can have serious consequences, including death. Once an addiction has formed, abstinence from opioids can cause severe withdrawal symptoms, which can lead to further drug use.\n</p><h3 id=\"signs-of-abuse-and-addiction\">Signs of abuse and addiction</h3><ul>\n<li>Taking different amounts of medication than prescribed could mean a higher dose, taking them more frequently, or taking them for a longer period than advised by your doctor.</li>\n<li>Taking the drugs differently than advised, such as crushing pills to be inhaled or injected.</li>\n<li>An uncontrollable inability to stop or cut down despite physical, mental, and social problems.</li>\n<li>Taking drugs for purposes other than pain relief, such as physical cravings or a desire to experience a high.</li>\n<li>Spending a lot of time trying to get more opioids from different sources. This might involve lying to your doctor, sourcing them from numerous doctors, ordering drugs online, stealing from others, purposefully hurting yourself to get a new prescription for pain relief, or buying them off the street.</li>\n<li>Signs of neglect might take the form of self-neglect, such as a lack of personal hygiene; neglecting responsibilities, such as household chores, paying bills, and attending to your job; or neglecting your relationships, including with friends and family members.</li>\n<li>Other symptoms include excessive sleeping, extreme weight loss or gain, and mood changes, including becoming nervous, on edge, and angry.</li>\n<li>Another key sign of opioid dependence is experiencing withdrawal symptoms.</li>\n</ul><h3 id=\"withdrawal-symptoms-even-people-with-a-very-slight-dependence-on-opioids-can-experience-withdrawal-symptoms-the-intensity-and-duration-of-the-withdrawal-process-depends-on-the-type-of-opioid-how-long-the-user-has-been-dependent-and-the-amount-they-have-been-taking-symptoms-include\">Withdrawal symptoms</h3><p>\nEven people with a very slight dependence on opioids can experience withdrawal symptoms. The intensity and duration of the withdrawal process depends on the type of opioid, how long the user has been dependent, and the amount they have been taking.\nSymptoms include:\n</p><ul>\n<li>Sweating</li>\n<li>Nausea, vomiting and diarrhea</li>\n<li>Cramps and muscle aches</li>\n<li>Tremors</li>\n<li>Flu-like symptoms</li>\n<li>Yawning</li>\n<li>Loss of appetite</li>\n<li>Disorientation</li>\n<li>Enlarged pupils</li>\n<li>Anxiety</li>\n<li>Insomnia</li>\n<li>Intense opioid cravings</li>\n</ul><p>\nWhile not usually life-threatening, withdrawal’s physical and mental discomfort can be extreme. Its unpleasantness can lead people to turn back to opioids to relieve the symptoms or because they believe the symptoms of opioid dependence are preferable to the symptoms of withdrawal.\n</p><h3 id=\"long-term-complications-long-term-opioid-dependence-can-impact-multiple-organs-including-the-brain-for-example-it-can-impair-the-brain-s-production-of-natural-feel-good-chemicals-dopamine-and-serotonin-and-interfere-with-inbuilt-pain-killing-processes-in-addition-over-time-the-body-develops-a-tolerance-to-opioids-requiring-higher-doses-to-feel-the-same-effect-which-in-turn-increases-addiction-and-associated-symptoms-other-long-term-complications-can-include\">Long-term complications</h3><p>\nLong-term opioid dependence can impact multiple organs, including the brain. For example, it can impair the brain’s production of natural feel-good chemicals (dopamine and serotonin) and interfere with inbuilt pain-killing processes. </p><p>In addition, over time, the body develops a tolerance to opioids, requiring higher doses to feel the same effect, which in turn increases addiction and associated symptoms.\nOther long-term complications can include:\n</p><ul>\n<li>A weakened immune system</li>\n<li>Hallucinations</li>\n<li>Risk of mental illness</li>\n<li>Slow breathing rate</li>\n<li>When opioids are injected, this can increase the risk of hepatitis, HIV or infectious diseases, and collapsed veins.</li>\n</ul><p>\nIn the most serious cases, opioid use disorder can result in coma or death.\n</p><span id=\"causes-of-opioid-dependence-anybody-can-develop-opioid-use-disorder-simply-using-opioids-beyond-a-few-days-can-increase-your-risk-of-dependence-however-there-are-other-factors-both-biological-and-social-that-make-some-people-more-susceptible-to-opioid-addiction-than-others-biological-risk-factors-include\" class=\"section-anchor-alias\" data-section-alias=\"causes-of-opioid-dependence\" aria-hidden=\"true\"></span><h2 id=\"causes-of-opioid-dependence\">Causes of opioid dependence</h2><p>\nAnybody can develop opioid use disorder - simply using opioids beyond a few days can increase your risk of dependence. However, there are other factors, both biological and social, that make some people more susceptible to opioid addiction than others.\nBiological risk factors include:\n</p><ul>\n<li>Personal or family history of substance misuse</li>\n<li>History of severe depression or anxiety</li>\n<li>Being female: women are more likely to be prescribed opioids for chronic pain, and a higher propensity for developing opioid dependency is linked to women having a smaller average body size than men⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#sex-differences-prescription-opioid-use\" data-reference-link=\"\" aria-label=\"Reference 1: Serdarevic, M., Striley, C. W., &amp; Cottler, L. B. (2017). Sex differences in prescription opioid use. Current Opinion in Psychiatry, 30(4), 238–246. PubMed Central.\" data-reference-number=\"1\">[1]</a></sup></li>\n</ul><p>\nSocial/environmental risk factors include:\n</p><ul>\n<li>Stressful living circumstances linked to poverty, unemployment and abuse</li>\n<li>Lack of access to medical care</li>\n<li>History of criminal activity</li>\n<li>Regular contact with people or places that increase the risk of substance abuse</li>\n</ul><span id=\"diagnosing-opioid-dependence-to-diagnose-opioid-use-disorder-a-doctor-or-psychologist-will-examine-your-current-usage-and-medical-history-and-might-ask-for-a-urine-sample-they-will-ask-about-your-pattern-of-opioid-use-over-a-12-month-period-and-measure-it-against-a-set-of-11-criteria-of-addiction-outlined-in-the-diagnostic-and-statistical-manual-of-mental-disorders-fifth-edition-dsm-5-based-on-these-findings-and-factors-about-your-work-housing-situation-history-of-substance-use-and-support-system-they-will-work-with-you-to-decide-the-best-course-of-substance-use-disorder-treatment\" class=\"section-anchor-alias\" data-section-alias=\"diagnosing-opioid-dependence\" aria-hidden=\"true\"></span><h2 id=\"diagnosing-opioid-dependence\">Diagnosing opioid dependence</h2><p>\nTo diagnose opioid use disorder a doctor or psychologist will examine your current usage and medical history and might ask for a urine sample. They will ask about your pattern of opioid use over a 12-month period and measure it against a set of 11 criteria of addiction outlined in The <a href=\"https://www.mentalhealth.com/library/dsm-5\" class=\"article-inline-link\" data-context-link=\"353\">Diagnostic and Statistical Manual of Mental Disorders</a>, fifth edition (DSM-5).\n</p><p>Based on these findings, and factors about your work, housing situation, history of substance use, and support system, they will work with you to decide the best course of substance use disorder treatment.\n</p><span id=\"treatment-for-opioid-use-and-dependence-to-stop-using-opioids-successfully-an-individual-must-be-fully-committed-to-treatment-it-involves-physical-psychological-and-behavioral-aspects-and-often-requires-continuing-care-to-have-the-highest-chance-of-success-treatment-can-take-place-at-home-or-in-a-hospital-or-if-problems-are-particularly-advanced-or-complex-you-might-be-transferred-to-a-specialist-residential-rehabilitation-center-treatment-centers-offer-medical-supervision-to-manage-withdrawal-symptoms-and-effective-treatments-for-opioid-abuse-such-as-talking-therapies-and-holistic-activities\" class=\"section-anchor-alias\" data-section-alias=\"treatment-for-opioid-use-and-dependence\" aria-hidden=\"true\"></span><h2 id=\"treatment-for-opioid-use-and-dependence\">Treatment for opioid use and dependence</h2><p>\nTo stop using opioids successfully, an individual must be fully committed to treatment. It involves physical, psychological, and behavioral aspects and often requires continuing care to have the highest chance of success.\n</p><p>Treatment can take place at home or in a hospital, or if problems are particularly advanced or complex, you might be transferred to a specialist residential rehabilitation center. Treatment centers offer medical supervision to manage withdrawal symptoms and effective treatments for opioid abuse such as talking therapies and holistic activities.\n</p><h3 id=\"medication-medication-assisted-treatment-mat-is-a-common-form-of-opioid-substitution-treatment-it-involves-behavioral-therapy-combined-with-medication-that-alleviates-withdrawal-symptoms-and-restores-chemical-balance-to-brain-processes-impacted-by-addiction-these-opioid-medications-also-reduce-cravings-and-block-the-addictive-euphoric-feeling-of-other-opioids-fda-approved-medications-for-treating-opioid-use-disorder-include\">Medication</h3><p>\n<a href=\"https://www.mentalhealth.com/library/medication-assisted-treatment\" class=\"article-inline-link\" data-context-link=\"358\">Medication-assisted treatment (MAT)</a> is a common form of opioid substitution treatment. It involves behavioral therapy combined with medication that alleviates withdrawal symptoms and restores chemical balance to brain processes impacted by addiction. These opioid medications also reduce cravings and block the addictive, euphoric feeling of other opioids.\nFDA-approved medications for treating opioid use disorder include:\n</p><ul>\n<li>Methadone</li>\n<li>Buprenorphine</li>\n<li>Naltrexone</li>\n</ul><p>\nLonger-term use of such medications can help to sustain recovery and prevent relapse. However, it is important to note that these medications are not designed to replace the opioid dependency they are treating - their dosage is tightly controlled to prevent further drug abuse and does not result in the same euphoric high. </p>\n<p>Using medication to treat opioid addiction is also known as maintenance therapy.\nAt some point during maintenance therapy, you can choose to detox, which involves gradually withdrawing from opioids altogether. </p><p>After detoxification, the physical dependency will have subsided, but many people still experience signs of psychological addiction. To avoid relapse in circumstances that might be triggering, ongoing counseling, therapy, and self-help are recommended.\n</p><h3 id=\"therapy-therapy-for-opioid-dependence-usually-involves-cognitive-behavioral-approaches-and-can-help-to\">Therapy</h3><p>\nTherapy for opioid dependence usually involves cognitive behavioral approaches and can help to:\n</p><ul>\n<li>Manage cravings</li>\n<li>Navigate triggering situations</li>\n<li>Build positive thoughts around treatment and recovery</li>\n<li>Help with any co-occurring mental disorders</li>\n<li>Encourage a healthy lifestyle</li>\n<li>Work on relationships with family, friends, employers, and the wider community</li>\n<li>Educate about how to prevent relapse</li>\n</ul><p>\nTherapy can also include people close to you or take place as part of a group with similar dependency issues. Other support services, such as Narcotics Anonymous, can also benefit long-term recovery.\n</p><h2 id=\"faqs-about-opioid-addiction\">FAQs about opioid addiction</h2><h3 id=\"what-is-the-outlook-for-people-with-opioid-addiction-opioid-use-disorder-is-a-serious-condition-people-who-misuse-opioids-are-at-a-higher-risk-of-critical-health-complications-and-premature-death-the-only-way-to-reduce-this-risk-is-to-quit-it-is-a-life-long-illness-and-it-is-common-for-people-to-relapse-at-some-point-on-the-road-to-recovery-however-there-is-plenty-of-support-for-those-seeking-help-and-many-people-overcome-opioid-addiction-with-the-right-treatment-studies-show-that-75-of-people-with-substance-use-disorders-including-opioid-use-disorder-survive-and-report-being-in-recovery\">What is the outlook for people with opioid addiction?</h3><p>Opioid use disorder is treatable. Medicines such as buprenorphine, methadone, and naltrexone are associated with lower overdose and mortality risk. Detoxification alone is not recommended as treatment because return to use and overdose remain risks. Care should also include access to naloxone and support suited to the individual⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#prevalence-correlates-ever-having-substance-use-problem-substance-use\" data-reference-link=\"\" aria-label=\"Reference 2: Centers for Disease Control and Prevention. (2024). Opioid Use Disorder: Treating. CDC. CDC. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.</p><section aria-label=\"Subject matter expert\" class=\"article-expert article-expert-inline\" data-expert-kind=\"related\" data-expert-layout=\"standard\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/2b7c0f84b1f18e263d570863.jpg\" width=\"64\" decoding=\"async\"><h2><a href=\"https://www.mentalhealth.com/people/peggy-ferguson\">Peggy Ferguson <span class=\"expert-credentials\">Ph.D.</span></a></h2></div><p class=\"article-expert-focus\">Addiction counseling and recovery</p><a class=\"profile-experience-link experience-button\" href=\"https://www.mentalhealth.com/people/peggy-ferguson\">View experience</a></section><h3 id=\"how-can-you-avoid-opioid-dependence-unlike-with-illicit-drugs-such-as-cocaine-it-is-easy-to-develop-an-addiction-to-opioids-simply-by-misusing-prescription-amounts-it-is-important-to-take-medication-containing-opioid-agonists-only-as-directed-by-your-doctor-and-to-understand-the-risks-of-doing-otherwise\">How can you avoid opioid dependence?</h3><p>\nUnlike with illicit drugs such as cocaine, it is easy to develop an addiction to opioids simply by misusing prescription amounts. It is important to take medication containing opioid agonists only as directed by your doctor and to understand the risks of doing otherwise.\n</p><p>When used only for a few days, the risk of becoming addicted to prescription opioids is significantly reduced. To treat long-term pain, speak to your doctor about an alternative medication.</p><p>You can also keep others safe from opioid use disorder by storing your medication securely, away from others, and by disposing of it properly. Your pharmacist, trash and recycling service, local law enforcement agency, or the Drug Enforcement Administration (DEA) should all have information about returning or safely disposing of unwanted opioids.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" data-reference-list=\"\" data-reference-style=\"author-date-title-source\" data-source-references=\"\" id=\"references\"><h2 id=\"references-2\">References</h2><ol><li id=\"sex-differences-prescription-opioid-use\" value=\"1\" data-reference-number=\"1\" data-reference-format=\"393\">Serdarevic, M., Striley, C. W., &amp; Cottler, L. B. (2017). <em class=\"reference-title\">Sex differences in prescription opioid use.</em> Current Opinion in Psychiatry, 30(4), 238–246. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC5675036/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-opioid-use-disorder&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed Central</a>.</li><li id=\"prevalence-correlates-ever-having-substance-use-problem-substance-use\" value=\"2\" data-reference-number=\"2\" data-reference-format=\"393\">Centers for Disease Control and Prevention. (2024). <em class=\"reference-title\">Opioid Use Disorder: Treating.</em> CDC. <a href=\"https://www.cdc.gov/overdose-prevention/hcp/clinical-care/opioid-use-disorder-treating.html?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-opioid-use-disorder&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">CDC</a>. Accessed October 10 2026.</li><li id=\"opioid-addiction\" value=\"3\" data-reference-number=\"3\" data-reference-format=\"393\">Azadfard, M., Huecker, M. R., &amp; Leaming, J. M. (2022). <em class=\"reference-title\">Opioid Addiction.</em> In StatPearls [Internet]. StatPearls Publishing. <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK448203/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-opioid-use-disorder&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>.</li><li id=\"prescription-opioid-epidemic-know-facts\" value=\"4\" data-reference-number=\"4\" data-reference-format=\"393\">American Medical Association Alliance. (2019). <em class=\"reference-title\">Prescription opioid epidemic: Know the facts [White paper].</em> American Medical Association Alliance. <span class=\"reference-note\">Original online source unavailable; citation details retained.</span></li></ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://www.mentalhealth.com/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://www.mentalhealth.com/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/227a39018d558e54bf0af4a6.webp\" width=\"64\" decoding=\"async\"><div><p class=\"article-bio-role\">Author</p><h3 id=\"erin-rodgers\"><a href=\"https://www.mentalhealth.com/people/erin-rodgers\">Erin Rodgers</a></h3><p class=\"article-bio-credentials\">MSc</p><p>Erin Rogers is medical writer with a Master's in Comparative Literature from The University of Edinburgh and a Bachelor's in English from the University of York.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-07-31T21:35:47Z\">July 31, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"64\" decoding=\"async\"><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"leila-khurshid-pharm-d\"><a href=\"https://www.mentalhealth.com/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h3><p class=\"article-bio-credentials\">Pharm.D., BCPS</p><p>Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-11-23\">November 23, 2022</time></dd></div></dl></div></section></div></section><section aria-label=\"Related community\" class=\"article-topic-community article-topic-community-end\"><img alt=\"\" class=\"topic-community-banner\" height=\"450\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/responsive/0f1309cc04080650561d60fc.webp\" width=\"800\" decoding=\"async\" srcset=\"/assets/responsive/0f1309cc04080650561d60fc.webp 800w\" sizes=\"(min-width: 961px) 236px, calc(100vw - 80px)\"><p class=\"topic-community-label\">Related community</p><h2>Substance Use Disorders</h2><p>Connect around experiences with substance use, its effects, and paths through recovery.</p><a href=\"https://www.mentalhealth.com/community/substance-use-disorders\">Explore community</a></section></div></div><aside aria-label=\"Article navigation and related information\" class=\"article-sidebar\" data-bounded-rail=\"\" tabindex=\"0\"><details class=\"article-contents\" data-expanded=\"false\" data-scrolled-past=\"false\" data-section-preview=\"3\" open=\"\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a aria-label=\"What are opioids?\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#what-are-opioids\" title=\"What are opioids?\">What are opioids?</a></li><li><a aria-label=\"What is opioid dependence?\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#what-is-opioid-dependence\" title=\"What is opioid dependence?\">What is opioid dependence?</a></li><li><a aria-label=\"How common is opioid dependence?\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#how-common-is-opioid-dependence\" title=\"How common is opioid dependence?\">How common is opioid dependence?</a></li><li><a aria-label=\"Signs and symptoms of opioid dependence\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#signs-and-symptoms-of-opioid-dependence\" title=\"Signs and symptoms of opioid dependence\">Signs and symptoms of opioid dependence</a></li><li><a aria-label=\"Causes of opioid dependence\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#causes-of-opioid-dependence\" title=\"Causes of opioid dependence\">Causes of opioid dependence</a></li><li><a aria-label=\"Diagnosing opioid dependence\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#diagnosing-opioid-dependence\" title=\"Diagnosing opioid dependence\">Diagnosing opioid dependence</a></li><li><a aria-label=\"Treatment for opioid use and dependence\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#treatment-for-opioid-use-and-dependence\" title=\"Treatment for opioid use and dependence\">Treatment for opioid use and dependence</a></li><li><a aria-label=\"FAQs about opioid addiction\" href=\"https://www.mentalhealth.com/library/opioid-use-disorder#faqs-about-opioid-addiction\" title=\"FAQs about opioid addiction\">FAQs about opioid addiction</a></li></ol><button aria-controls=\"article-section-list\" aria-expanded=\"false\" class=\"article-sections-toggle\" data-sections-toggle=\"\" type=\"button\">View more</button></nav></details></aside></div></div></div>","text":"Home Library Substance Use Disorders Opioid Use Disorder Opioid Use Disorder Written by Erin RodgersMedically reviewed by Leila Khurshid, Pharm.D. Published on November 22, 2022 · Updated on July 31, 2025 Opioid use disorder is developed when a class of drugs called opioids, or opiates, are misused. They are highly addictive, and their misuse can lead to serious health complications, but dependence can be treated by detoxification assisted by medication and therapy. Key takeaways Opioid use disorder can involve compulsive use of prescription or illicit opioids despite harmful consequences. Dependence, withdrawal, health complications, and disruptions to daily life can accompany problematic opioid use. Medication and therapy support treatment, while supervised prescribing and secure medication storage can reduce preventable risks. What are opioids? Opioids are often prescribed as painkillers, but some street drugs also come under this category. Traditionally derived from the opium poppy, some opioids are now made synthetically. Common examples of opioids include: Morphine Codeine Oxycodone Fentanyl Tramadol Heroin Aside from relieving pain and anxiety, they can also affect the brain by creating a feeling of numbness and euphoria, often experienced as a ‘high.’ What is opioid dependence? Opioid use disorder is the consequence of using opioids beyond their intended purpose, often leading to both physical and mental addiction. Opioid addiction can stem from the misuse of prescription drugs, leading to cravings, a harmful preoccupation with sourcing more, and intense withdrawal symptoms if unable to do so. Over time, increased resilience often leads to increased dosage, which can severely impact the person’s physical health, mental health, and social well-being. How common is opioid dependence? The opioid crisis was declared a nationwide Public Health Emergency on October 27, 2017. Around 3 million people in the United States are living with opioid use disorder or have experienced it in the past⁠[3].This has led to a dramatic rise in the number of opioid overdose cases, primarily due to an influx of fentanyl on the streets, a synthetic opioid that is 50 times stronger than heroin. The risk of overdose from fentanyl is far greater than with other opioids and will often end in death without intervention. According to the American Medical Association (AMA), between 3 - 19% of people who use prescribed pain medications develop an addiction, and about 45% of heroin addictions originate from an addiction to prescribed opioids⁠[4]. Signs and symptoms of opioid dependence Opioid dependence and addiction can manifest in various physical and mental symptoms and behavioral changes. It is a chronic, lifelong disorder that can have serious consequences, including death. Once an addiction has formed, abstinence from opioids can cause severe withdrawal symptoms, which can lead to further drug use. Signs of abuse and addiction Taking different amounts of medication than prescribed could mean a higher dose, taking them more frequently, or taking them for a longer period than advised by your doctor. Taking the drugs differently than advised, such as crushing pills to be inhaled or injected. An uncontrollable inability to stop or cut down despite physical, mental, and social problems. Taking drugs for purposes other than pain relief, such as physical cravings or a desire to experience a high. Spending a lot of time trying to get more opioids from different sources. This might involve lying to your doctor, sourcing them from numerous doctors, ordering drugs online, stealing from others, purposefully hurting yourself to get a new prescription for pain relief, or buying them off the street. Signs of neglect might take the form of self-neglect, such as a lack of personal hygiene; neglecting responsibilities, such as household chores, paying bills, and attending to your job; or neglecting your relationships, including with friends and family members. Other symptoms include excessive sleeping, extreme weight loss or gain, and mood changes, including becoming nervous, on edge, and angry. Another key sign of opioid dependence is experiencing withdrawal symptoms. Withdrawal symptoms Even people with a very slight dependence on opioids can experience withdrawal symptoms. The intensity and duration of the withdrawal process depends on the type of opioid, how long the user has been dependent, and the amount they have been taking. Symptoms include: Sweating Nausea, vomiting and diarrhea Cramps and muscle aches Tremors Flu-like symptoms Yawning Loss of appetite Disorientation Enlarged pupils Anxiety Insomnia Intense opioid cravings While not usually life-threatening, withdrawal’s physical and mental discomfort can be extreme. Its unpleasantness can lead people to turn back to opioids to relieve the symptoms or because they believe the symptoms of opioid dependence are preferable to the symptoms of withdrawal. Long-term complications Long-term opioid dependence can impact multiple organs, including the brain. For example, it can impair the brain’s production of natural feel-good chemicals (dopamine and serotonin) and interfere with inbuilt pain-killing processes. In addition, over time, the body develops a tolerance to opioids, requiring higher doses to feel the same effect, which in turn increases addiction and associated symptoms. Other long-term complications can include: A weakened immune system Hallucinations Risk of mental illness Slow breathing rate When opioids are injected, this can increase the risk of hepatitis, HIV or infectious diseases, and collapsed veins. In the most serious cases, opioid use disorder can result in coma or death. Causes of opioid dependence Anybody can develop opioid use disorder - simply using opioids beyond a few days can increase your risk of dependence. However, there are other factors, both biological and social, that make some people more susceptible to opioid addiction than others. Biological risk factors include: Personal or family history of substance misuse History of severe depression or anxiety Being female: women are more likely to be prescribed opioids for chronic pain, and a higher propensity for developing opioid dependency is linked to women having a smaller average body size than men⁠[1] Social/environmental risk factors include: Stressful living circumstances linked to poverty, unemployment and abuse Lack of access to medical care History of criminal activity Regular contact with people or places that increase the risk of substance abuse Diagnosing opioid dependence To diagnose opioid use disorder a doctor or psychologist will examine your current usage and medical history and might ask for a urine sample. They will ask about your pattern of opioid use over a 12-month period and measure it against a set of 11 criteria of addiction outlined in The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). Based on these findings, and factors about your work, housing situation, history of substance use, and support system, they will work with you to decide the best course of substance use disorder treatment. Treatment for opioid use and dependence To stop using opioids successfully, an individual must be fully committed to treatment. It involves physical, psychological, and behavioral aspects and often requires continuing care to have the highest chance of success. Treatment can take place at home or in a hospital, or if problems are particularly advanced or complex, you might be transferred to a specialist residential rehabilitation center. Treatment centers offer medical supervision to manage withdrawal symptoms and effective treatments for opioid abuse such as talking therapies and holistic activities. Medication Medication-assisted treatment (MAT) is a common form of opioid substitution treatment. It involves behavioral therapy combined with medication that alleviates withdrawal symptoms and restores chemical balance to brain processes impacted by addiction. These opioid medications also reduce cravings and block the addictive, euphoric feeling of other opioids. FDA-approved medications for treating opioid use disorder include: Methadone Buprenorphine Naltrexone Longer-term use of such medications can help to sustain recovery and prevent relapse. However, it is important to note that these medications are not designed to replace the opioid dependency they are treating - their dosage is tightly controlled to prevent further drug abuse and does not result in the same euphoric high. Using medication to treat opioid addiction is also known as maintenance therapy. At some point during maintenance therapy, you can choose to detox, which involves gradually withdrawing from opioids altogether. After detoxification, the physical dependency will have subsided, but many people still experience signs of psychological addiction. To avoid relapse in circumstances that might be triggering, ongoing counseling, therapy, and self-help are recommended. Therapy Therapy for opioid dependence usually involves cognitive behavioral approaches and can help to: Manage cravings Navigate triggering situations Build positive thoughts around treatment and recovery Help with any co-occurring mental disorders Encourage a healthy lifestyle Work on relationships with family, friends, employers, and the wider community Educate about how to prevent relapse Therapy can also include people close to you or take place as part of a group with similar dependency issues. Other support services, such as Narcotics Anonymous, can also benefit long-term recovery. FAQs about opioid addiction What is the outlook for people with opioid addiction? Opioid use disorder is treatable. Medicines such as buprenorphine, methadone, and naltrexone are associated with lower overdose and mortality risk. Detoxification alone is not recommended as treatment because return to use and overdose remain risks. Care should also include access to naloxone and support suited to the individual⁠[2]. Subject matter expert Peggy Ferguson Ph.D. Addiction counseling and recovery View experience How can you avoid opioid dependence? Unlike with illicit drugs such as cocaine, it is easy to develop an addiction to opioids simply by misusing prescription amounts. It is important to take medication containing opioid agonists only as directed by your doctor and to understand the risks of doing otherwise. When used only for a few days, the risk of becoming addicted to prescription opioids is significantly reduced. To treat long-term pain, speak to your doctor about an alternative medication. You can also keep others safe from opioid use disorder by storing your medication securely, away from others, and by disposing of it properly. Your pharmacist, trash and recycling service, local law enforcement agency, or the Drug Enforcement Administration (DEA) should all have information about returning or safely disposing of unwanted opioids. References Serdarevic, M., Striley, C. W., & Cottler, L. B. (2017). Sex differences in prescription opioid use. Current Opinion in Psychiatry, 30(4), 238–246. PubMed Central. Centers for Disease Control and Prevention. (2024). Opioid Use Disorder: Treating. CDC. CDC. Accessed October 10 2026. Azadfard, M., Huecker, M. R., & Leaming, J. M. (2022). Opioid Addiction. In StatPearls [Internet]. StatPearls Publishing. National Library of Medicine. American Medical Association Alliance. (2019). Prescription opioid epidemic: Know the facts [White paper]. American Medical Association Alliance. Original online source unavailable; citation details retained. Medical Content The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy. About MentalHealth.com MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life. Author Erin Rodgers MSc Erin Rogers is medical writer with a Master's in Comparative Literature from The University of Edinburgh and a Bachelor's in English from the University of York. Published November 22, 2022 Updated July 31, 2025 Medical Reviewer Leila Khurshid, Pharm.D. Pharm.D., BCPS Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital. Reviewed November 23, 2022 Related community Substance Use Disorders Connect around experiences with substance use, its effects, and paths through recovery. Explore community Table of contentsChoose a section What are opioids? What is opioid dependence? How common is opioid dependence? Signs and symptoms of opioid dependence Causes of opioid dependence Diagnosing opioid dependence Treatment for opioid use and dependence FAQs about opioid addiction View more","wordCount":1953},"schema":{"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://www.mentalhealth.com/#organization","name":"MentalHealth.com","url":"https://www.mentalhealth.com/","publishingPrinciples":"https://www.mentalhealth.com/publishing/editorial-policy"},{"@type":"WebSite","@id":"https://www.mentalhealth.com/#website","url":"https://www.mentalhealth.com/","name":"MentalHealth.com","inLanguage":"en-US","publisher":{"@id":"https://www.mentalhealth.com/#organization"}},{"@type":"BreadcrumbList","@id":"https://www.mentalhealth.com/library/opioid-use-disorder#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.mentalhealth.com/"},{"@type":"ListItem","position":2,"name":"Library","item":"https://www.mentalhealth.com/library"},{"@type":"ListItem","position":3,"name":"Substance Use Disorders","item":"https://www.mentalhealth.com/library/substance-use-disorders"},{"@type":"ListItem","position":4,"name":"Opioid Use Disorder","item":"https://www.mentalhealth.com/library/opioid-use-disorder"}]},{"@type":"ImageObject","@id":"https://www.mentalhealth.com/library/opioid-use-disorder#primaryimage","url":"https://www.mentalhealth.com/assets/optimized/6731c1b4f759cd691a05e238.webp","contentUrl":"https://www.mentalhealth.com/assets/optimized/6731c1b4f759cd691a05e238.webp","width":1200,"height":675,"encodingFormat":"image/webp","caption":"People lean toward one another during a small group conversation."},{"@type":"Person","@id":"https://www.mentalhealth.com/people/erin-rodgers#person","name":"Erin Rodgers","url":"https://www.mentalhealth.com/people/erin-rodgers","jobTitle":"MSc","image":"https://www.mentalhealth.com/assets/optimized/227a39018d558e54bf0af4a6.webp","sameAs":["https://www.linkedin.com/in/erin-rodgers-404b20102/"],"memberOf":[{"@id":"https://www.mentalhealth.com/publishing#department"}]},{"@type":"Person","@id":"https://www.mentalhealth.com/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://www.mentalhealth.com/people/leila-khurshid","jobTitle":"Pharm.D., BCPS","image":"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp","sameAs":["https://www.linkedin.com/in/leila-khurshid-pharmd-bcps/"],"memberOf":[{"@id":"https://www.mentalhealth.com/clinical-affairs#department"}]},{"@type":"Article","@id":"https://www.mentalhealth.com/library/opioid-use-disorder#article","url":"https://www.mentalhealth.com/library/opioid-use-disorder","headline":"Opioid Use Disorder","description":"Opioid use disorder refers to a person's inability to control their use of the substance. 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W., & Cottler, L. B. (2017). Sex differences in prescription opioid use. Current Opinion in Psychiatry, 30(4), 238–246. PubMed Central.","links":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5675036/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-opioid-use-disorder&utm_source=mentalhealth.com","label":"PubMed Central"}],"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5675036/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-opioid-use-disorder&utm_source=mentalhealth.com"},{"number":2,"id":"https://www.mentalhealth.com/library/opioid-use-disorder#prevalence-correlates-ever-having-substance-use-problem-substance-use","text":"Centers for Disease Control and Prevention. (2024). Opioid Use Disorder: Treating. CDC. CDC. Accessed October 10 2026.","links":[{"url":"https://www.cdc.gov/overdose-prevention/hcp/clinical-care/opioid-use-disorder-treating.html?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-opioid-use-disorder&utm_source=mentalhealth.com","label":"CDC"}],"url":"https://www.cdc.gov/overdose-prevention/hcp/clinical-care/opioid-use-disorder-treating.html?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-opioid-use-disorder&utm_source=mentalhealth.com"},{"number":3,"id":"https://www.mentalhealth.com/library/opioid-use-disorder#opioid-addiction","text":"Azadfard, M., Huecker, M. R., & Leaming, J. M. (2022). Opioid Addiction. In StatPearls [Internet]. StatPearls Publishing. 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