{"formatVersion":"1.1","id":"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects","path":"/library/paroxetine-uses-dosage-side-effects","url":"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects","title":"Paroxetine (Paxil)","family":"Library detail","description":"Paroxetine is an antidepressant used to treat anxiety disorder, major depression, post-traumatic stress disorder, and a number of other mental health disorders.","language":"en-US","access":{"audience":"public","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects","wordpressId":"228","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://www.mentalhealth.com/people/jenni-jacobsen#person","name":"Jenni Jacobsen, Ph.D.","url":"https://www.mentalhealth.com/people/jenni-jacobsen"}],"reviewer":{"@type":"Person","@id":"https://www.mentalhealth.com/people/leila-khurshid#person","name":"Leila Khurshid, Pharm.D.","url":"https://www.mentalhealth.com/people/leila-khurshid"},"dates":{"datePublished":"2022-11-22T19:00:00Z","dateModified":"2025-11-23T10:41:02Z","lastReviewed":"2022-11-23"},"content":{"html":"<nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\"><ol><li><a href=\"https://www.mentalhealth.com/\">Home</a></li><li><a href=\"https://www.mentalhealth.com/library\">Library</a></li><li><a href=\"https://www.mentalhealth.com/library/medications\">Medications</a></li><li><span aria-current=\"page\">Paroxetine (Paxil)</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard=\"\"><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Paroxetine (Paxil)</h1><p class=\"article-inline-credits\"><span>Written by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/jenni-jacobsen\"><img alt=\"\" height=\"22\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/4f4e4293be2246dfe2e00d7c.jpg\" width=\"22\" decoding=\"async\">Jenni Jacobsen, Ph.D.</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/leila-khurshid\"><img alt=\"\" height=\"22\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"22\" decoding=\"async\">Leila Khurshid, Pharm.D.</a></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-11-23T10:41:02Z\">November 23, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Paroxetine, also known by its brand name of Paxil, is a selective serotonin reuptake inhibitor (SSRI). It is commonly used to treat depression but may also be used to treat anxiety disorders, including generalized anxiety disorder and social anxiety disorder⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>.</p></div><figure class=\"article-feature\"><img alt=\"A healthcare professional rests a reassuring hand on a patient's knee.\" decoding=\"async\" height=\"630\" loading=\"eager\" src=\"https://www.mentalhealth.com/assets/optimized/8debdbe7c5f9c329801a75ed.webp\" width=\"1200\" srcset=\"/assets/responsive/05f52c7b2d553cf8657dd303.webp 800w, /assets/optimized/8debdbe7c5f9c329801a75ed.webp 1200w\" sizes=\"(max-width: 800px) 100vw, 1200px\"></figure><section aria-labelledby=\"key-takeaways\" class=\"article-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Paroxetine is an SSRI used for depression and several anxiety-related conditions.</li><li>Paroxetine increases serotonin availability, and symptom improvement develops over time.</li><li>Drug interactions, adverse effects, and symptoms after discontinuation require attention even though paroxetine is not generally considered addictive.</li></ul></section><span id=\"paroxetine-brand-names-while-paroxetine-refers-to-the-generic-or-chemical-name-of-the-medication-this-drug-can-be-sold-under-several-brand-names\" class=\"section-anchor-alias\" data-section-alias=\"paroxetine-brand-names\" aria-hidden=\"true\"></span><h2 id=\"paroxetine-brand-names\">Paroxetine brand names</h2><p>\nWhile paroxetine refers to the generic or chemical name of the medication, this drug can be sold under several brand names⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-medlineplus-drug-information\" data-reference-link=\"\" aria-label=\"Reference 2: Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>:\n</p><ul>\n<li>Paxil</li>\n<li>Paxil CR</li>\n<li>Pexeva</li>\n<li>Brisdelle</li>\n</ul><section aria-label=\"Subject matter expert\" class=\"article-expert article-expert-inline\" data-expert-kind=\"related\" data-expert-layout=\"standard\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"card-identity-photo\" aria-label=\"Leila Khurshid, Pharm.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"64\" decoding=\"async\"></a><h2><a href=\"https://www.mentalhealth.com/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"quiet-button\">View profile</a></section><span id=\"what-is-paroxetine-prescribed-for-as-an\" class=\"section-anchor-alias\" data-section-alias=\"what-is-paroxetine-prescribed-for\" aria-hidden=\"true\"></span><h2 id=\"what-is-paroxetine-prescribed-for\">What is paroxetine prescribed for?</h2><p>\nAs an <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/antidepressants\">antidepressant</a> SSRI medication, paroxetine is most notable for its use in the treatment of depression. Other conditions that healthcare providers commonly prescribe paroxetine for include⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>:\n</p><ul>\n<li>Major depressive disorder (MDD)</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/obsessive-compulsive-disorder\">Obsessive-compulsive disorder</a> (OCD)</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/social-anxiety\">Social anxiety disorder</a> (SAD)</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/panic-attacks-in-anxiety-disorders\">Panic disorder</a></li>\n<li>Post-traumatic stress disorder (PTSD)</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/generalized-anxiety-disorder\">Generalized anxiety disorder</a> (GAD)</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/premenstrual-dysphoric-disorder-pmdd\">Premenstrual dysphoric disorder</a></li>\n<li>Menopausal symptoms like hot flashes</li>\n<li>Depression with <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/bipolar-disorder\">bipolar disorder</a></li>\n</ul><p>\nParoxetine is not intended to be prescribed for children under 18, but some physicians may use it for teens and children with an obsessive-compulsive disorder or social anxiety disorder⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>.\nBeyond the uses noted above, some less common uses of paroxetine are as follows⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>:\n</p><ul>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/treatment-for-separation-anxiety-disorder\">Separation anxiety disorder</a></li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/dysthymic-disorder\">Dysthymia</a> (persistent depression)</li>\n<li>Body dysmorphic disorder</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/postpartum-depression-neurotransmitters-and-nutrition\">Postpartum depression</a></li>\n<li>Premature ejactulation</li>\n</ul><span id=\"how-does-paroxetine-work-paroxetine-works-by-changing-the-availability-of-a-neurotransmitter-or-brain-chemical-called-serotonin-as-a-selective-serotonin-reuptake-inhibitor-ssri-paroxetine-increases-the-availability-of-serotonin-in-the-nervous-system-this-is-important-because-low-serotonin-concentrations-are-believed-to-be-involved-in-symptoms-of-depression-can-help-with-anxiety-symptoms-such-as-panic-attacks-and-relieve-symptoms-of-post-traumatic-stress-disorder\" class=\"section-anchor-alias\" data-section-alias=\"how-does-paroxetine-work\" aria-hidden=\"true\"></span><h2 id=\"how-does-paroxetine-work\">How does paroxetine work?</h2><p>\nParoxetine works by changing the availability of a neurotransmitter, or brain chemical, called serotonin. As a selective serotonin reuptake inhibitor (SSRI), paroxetine increases the availability of serotonin in the nervous system. This is important because low serotonin concentrations are believed to be involved in symptoms of depression, can help with anxiety symptoms such as panic attacks, and relieve symptoms of post-traumatic stress disorder⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>.\n</p><span id=\"how-is-paroxetine-usually-taken-paroxetine-is-taken-orally-typically-as-a-pill-in-addition-it-is-available-as-a-regular-and-extended-release-tablet-which-is-released-slowly-into-the-body\" class=\"section-anchor-alias\" data-section-alias=\"how-is-paroxetine-usually-taken\" aria-hidden=\"true\"></span><h2 id=\"how-is-paroxetine-usually-taken\">How is paroxetine usually taken?</h2><p>\nParoxetine is taken orally, typically as a pill. In addition, it is available as a regular and extended-release tablet, which is released slowly into the body⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>.\n</p><p>Initial doses of paroxetine tablets are prescribed with a typical starting dose of 20 mg daily for depression. The daily dose may be increased by 10mg each week until a person reaches a dose of 50 mg per day. </p><p>The extended-release pill is typically started at a dose of 25 mg per day, with an increase of 12.5 mg per day until a maximum dose of 62.5 mg daily is reached⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>.</p><p>\nDoses may vary slightly based on the condition for which paroxetine is prescribed. For instance, dosages for anxiety may vary from dosages for depression or other conditions. Doses may also be lower for individuals with kidney or liver problems. Your doctor can determine the best dose for your specific needs⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" data-reference-link=\"\" aria-label=\"Reference 1: Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine.\" data-reference-number=\"1\">[1]</a></sup>.\n</p><span id=\"how-long-does-paroxetine-stay-in-your-system-paroxetine-has-a-half-life-of-21-hours-meaning-that-every-21-hours-half-of-the-concentration-of-the-drug-is-removed-from-the-body-given-this-fact-paroxetine-is-completely-eliminated-from-the-system-within-about-five-days\" class=\"section-anchor-alias\" data-section-alias=\"how-long-does-paroxetine-stay-in-your-system\" aria-hidden=\"true\"></span><h2 id=\"how-long-does-paroxetine-stay-in-your-system\">How long does paroxetine stay in your system?</h2><p>\nParoxetine has a half-life of 21 hours, meaning that every 21 hours, half of the concentration of the drug is removed from the body. Given this fact, paroxetine is completely eliminated from the system within about five days⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-review\" data-reference-link=\"\" aria-label=\"Reference 3: Bourin, M., Chue, P., &amp; Guillon, Y. (2006). Paroxetine: A review. CNS Drug Reviews, 7(1), 25-47. Wiley. Accessed October 10 2026.\" data-reference-number=\"3\">[3]</a></sup>.\n</p><span id=\"paroxetine-side-effects-while-paroxetine-is-an-approved-medication-with-legitimate-medical-uses-that-does-not-mean-that-it-is-without-side-effects-the-following-common-side-effects-with-paroxetine-use-are-generally-considered-to-be-mild-but-may-still-require-medical-advice\" class=\"section-anchor-alias\" data-section-alias=\"paroxetine-side-effects\" aria-hidden=\"true\"></span><h2 id=\"paroxetine-side-effects\">Paroxetine side effects</h2><p>\nWhile paroxetine is an approved medication with legitimate medical uses, that does not mean that it is without side effects. The following common side effects with paroxetine use are generally considered to be mild but may still require medical advice⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-medlineplus-drug-information\" data-reference-link=\"\" aria-label=\"Reference 2: Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>:\n</p><ul>\n<li>Problems concentrating</li>\n<li>Weakness or dizziness</li>\n<li>Headaches</li>\n<li>Confusion or forgetfulness</li>\n<li>Feelings of nervousness</li>\n<li>Sleepiness</li>\n<li>Gastrointestinal symptoms like nausea, vomiting, or diarrhea</li>\n<li>Gas and constipation</li>\n<li>Stomach pain</li>\n<li>Muscle and joint pain</li>\n<li>Dry mouth</li>\n<li>Reduced sex drive</li>\n<li>Changes in appetite</li>\n<li>Weight loss or gain</li>\n</ul><p>\nSome of the more serious adverse effects of paroxetine include⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-medlineplus-drug-information\" data-reference-link=\"\" aria-label=\"Reference 2: Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>:\n</p><ul>\n<li>Hallucinations</li>\n<li>Racing heart/irregular heartbeat</li>\n<li>Fainting</li>\n<li>Chest pain</li>\n<li>Seizures</li>\n<li>Breathing problems</li>\n<li>Uncoordinated walking/falling</li>\n<li>Abnormal bleeding or bruising</li>\n<li>Signs of infection, such as fever, chills, or cough</li>\n<li>Peeling or blistering skin</li>\n<li>Numbness in your legs, arms, hands, or feet</li>\n<li>Uncontrollable shaking in the body</li>\n<li>Hives, rash, or itching</li>\n<li>Bloody vomit or stools</li>\n<li>Swelling in the face or other parts of the body</li>\n<li>Painful erections lasting for hours</li>\n<li>Risk of serotonin syndrome</li>\n<li>Discontinuation syndrome</li>\n</ul><p>\nWhile mild paroxetine side effects are manageable and will improve with time, you should seek immediate medical attention if you experience severe side effects. If you have continuous side effects that do not improve with time or that interfere significantly with daily life, talk with your doctor.\n</p><span id=\"paroxetine-precautions-before-taking-paroxetine-you-should-tell-your-doctor-about-any-other-health-conditions-or-medications-you-are-taking-your-doctor-will-determine-whether-any-dose-adjustments-need-to-be-made-to-accommodate-your-health-problems-your-doctor-may-also-choose-a-different-medication-if-paroxetine-could-interact-negatively-with-other-prescriptions-you-are-taking-another-precaution-that-comes-along-with-paroxetine-is-the-potential-increased-risk-of-suicidal-thoughts-children-teens-and-young-adults-may-experience-increased-suicidal-thinking-after-being-prescribed-paroxetine-it-is-important-to-discuss-this-risk-with-your-doctor-and-weigh-the-risks-and-benefits-of-taking-the-medication-sometimes-the-risk-of-not-using-paroxetine-is-greater-than-the-risk-of-taking-the-medication-as-untreated-depression-can-also-increase-suicide-risk\" class=\"section-anchor-alias\" data-section-alias=\"paroxetine-precautions\" aria-hidden=\"true\"></span><h2 id=\"paroxetine-precautions\">Paroxetine precautions</h2><p>\nBefore taking paroxetine, you should tell your doctor about any other health conditions or medications you are taking. Your doctor will determine whether any dose adjustments need to be made to accommodate your health problems. Your doctor may also choose a different medication if paroxetine could interact negatively with other prescriptions you are taking.\n</p>\n<p>Another precaution that comes along with paroxetine is the potential increased risk of suicidal thoughts. Children, teens, and young adults may experience increased suicidal thinking after being prescribed paroxetine. It is important to discuss this risk with your doctor and weigh the risks and benefits of taking the medication. </p><p>Sometimes, the risk of not using paroxetine is greater than the risk of taking the medication, as untreated depression can also increase suicide risk⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-medlineplus-drug-information\" data-reference-link=\"\" aria-label=\"Reference 2: Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.\n</p><span id=\"paroxetine-drug-interactions-as-noted-above-paroxetine-may-interact-with-other-medications-you-are-taking-some-medications-that-may-interact-negatively-with-paroxetine-include\" class=\"section-anchor-alias\" data-section-alias=\"paroxetine-drug-interactions\" aria-hidden=\"true\"></span><h2 id=\"paroxetine-drug-interactions\">Paroxetine drug interactions</h2><p>\nAs noted above, paroxetine may interact with other medications you are taking. Some medications that may interact negatively with paroxetine include⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paxil-paroxetine-hydrochloride-tablets-oral-suspension-prescribing-information\" data-reference-link=\"\" aria-label=\"Reference 4: FDA.gov. (2012, December). PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension Prescribing Information. FDA.gov. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"4\">[4]</a></sup>:\n</p><ul>\n<li>Tryptophan</li>\n<li>Pimozide</li>\n<li>Lithium</li>\n<li>Fentanyl</li>\n<li>Tramadol</li>\n<li>Thioridazine</li>\n<li>St. John’s wort</li>\n<li>Warfarin</li>\n<li>Phenobarbital</li>\n<li>Cimetidine</li>\n<li>Phenytoin</li>\n<li>Theophylline</li>\n<li>NSAIDs, like ibuprofen</li>\n<li>Fosamprenavir</li>\n<li>Ritonavir</li>\n<li>Digoxin</li>\n<li>Tricyclic antidepressants, like <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/protriptyline-uses-dosage-side-effects\">protriptyline</a>, <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/amitriptyline-use-doses-side-effects\">amitriptyline</a>, and desipramine</li>\n<li>Atomoxetine</li>\n<li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/risperidone-use-doses-side-effects\">Risperidone</a></li>\n<li>MAOIs, like selegiline, isocarboxazid, and <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/phenelzine-uses-dosage-side-effects\">phenelzine</a></li>\n</ul><p>\nIf you are also taking one of these medications, it may be unsafe for you to take paroxetine. Be sure to tell your doctor about all other medications you are taking, as paroxetine may interact with other prescription drugs not included on this list.\n</p><span id=\"paroxetine-storage-paroxetine-should-be-stored-in-the-original-prescription-container-and-kept-at-a-temperature-of-15-30-degrees-celsius-or-59-to-86-degrees-fahrenheit\" class=\"section-anchor-alias\" data-section-alias=\"paroxetine-storage\" aria-hidden=\"true\"></span><h2 id=\"paroxetine-storage\">Paroxetine storage</h2><p>\nParoxetine should be stored in the original prescription container and kept at a temperature of 15-30 degrees Celsius or 59 to 86 degrees Fahrenheit⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paxil-paroxetine-hydrochloride-tablets-oral-suspension-prescribing-information\" data-reference-link=\"\" aria-label=\"Reference 4: FDA.gov. (2012, December). PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension Prescribing Information. FDA.gov. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"4\">[4]</a></sup>. </p><p>Failing to store paroxetine in the original container, with the prescription label, could result in someone accidentally taking a medication not intended for them, which can be dangerous. In addition, storing the medication at extreme temperatures can change some of the chemicals in the drug.\n</p><span id=\"what-to-do-if-you-overdose-on-paroxetine-taking-too-large-of-a-dose-of-paroxetine-can-result-in-an-overdose-some-paroxetine-overdose-symptoms-include\" class=\"section-anchor-alias\" data-section-alias=\"what-to-do-if-you-overdose-on-paroxetine\" aria-hidden=\"true\"></span><h2 id=\"what-to-do-if-you-overdose-on-paroxetine\">What to do if you overdose on paroxetine</h2><p>\nTaking too large of a dose of paroxetine can result in an overdose. Some paroxetine overdose symptoms include⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-medlineplus-drug-information\" data-reference-link=\"\" aria-label=\"Reference 2: Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>:\n</p><ul>\n<li>Drowsiness</li>\n<li>Seizures</li>\n<li>Coma</li>\n<li>Nausea, vomiting, or diarrhea</li>\n<li>Aggression</li>\n<li>Urine that is dark red or brown in color</li>\n<li>Extremely excited mood</li>\n<li>Elevated heart rate</li>\n<li>Severe twitching or stiffness of muscles</li>\n<li>Confusion</li>\n<li>Fever or sweating</li>\n</ul><p>\nIf you or a loved one experiences these symptoms while taking paroxetine, call the nearest Poison Control Center or report immediately to the local emergency room. A patient who collapses, has a seizure, cannot be awakened, or struggles to breathe requires emergency medical attention. Contact 911 immediately⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-medlineplus-drug-information\" data-reference-link=\"\" aria-label=\"Reference 2: Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026.\" data-reference-number=\"2\">[2]</a></sup>.\n</p><span id=\"frequently-asked-questions-about-paroxetine-the-answers-to-the-following-common-questions-provide-additional-information-about-paroxetine\" class=\"section-anchor-alias\" data-section-alias=\"frequently-asked-questions-about-paroxetine\" aria-hidden=\"true\"></span><h2 id=\"frequently-asked-questions-about-paroxetine\">Frequently asked questions about paroxetine</h2><p>\nThe answers to the following common questions provide additional information about paroxetine.\n</p><h3 id=\"how-long-does-it-take-for-paroxetine-to-work-everyone-will-respond-differently-to-paroxetine-depending-upon-their-unique-medical-history-symptom-profile-and-metabolism-people-generally-notice-an-improvement-in-sleep-appetite-and-energy-levels-within-a-week-or-two-of-beginning-paroxetine-other-symptoms-may-not-improve-immediately-including-depressed-mood-and-lack-of-pleasure-with-usual-activities-it-may-take-6-8-weeks-to-experience-the-full-benefits-of-paroxetine\">How long does it take for paroxetine to work?</h3><p>\nEveryone will respond differently to paroxetine, depending upon their unique medical history, symptom profile, and metabolism. People generally notice an improvement in sleep, appetite, and energy levels within a week or two of beginning paroxetine. </p><p>Other symptoms may not improve immediately, including depressed mood and lack of pleasure with usual activities. It may take 6-8 weeks to experience the full benefits of paroxetine⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-paxil-nami-national-alliance-mental-illness\" data-reference-link=\"\" aria-label=\"Reference 5: Paroxetine (Paxil) | NAMI: National Alliance on Mental Illness. (n.d.). NAMI. Accessed October 10 2026.\" data-reference-number=\"5\">[5]</a></sup>. Do not be discouraged if the medication does not immediately improve depression symptoms.\n</p><h3 id=\"is-paroxetine-addictive-paroxetine-is-generally-not-considered-addictive-in-the-same-way-that-substances-of-abuse-such-as-cocaine-or-heroin-are-addictive-however-people-may-become-dependent-upon-the-medication-meaning-that-the-body-does-not-function-the-same-without-it-this-means-abrupt-discontinuation-of-paroxetine-can-lead-to-withdrawal-side-effects-like-irritability-depressed-mood-agitation-dizziness-ringing-in-the-ears-anxiety-confusion-headache-mood-swings-sleep-problems-or-lethargic-behavior-to-prevent-withdrawal-healthcare-providers-generally-recommend-that-patients-gradually-taper-their-doses-of-paroxetine-before-stopping-the-medication-completely\">Is paroxetine addictive?</h3><p>\nParoxetine is generally not considered addictive in the same way that substances of abuse, such as cocaine or heroin, are addictive. However, people may become dependent upon the medication, meaning that the body does not function the same without it. </p><p>This means abrupt discontinuation of paroxetine can lead to withdrawal side effects, like irritability, depressed mood, agitation, dizziness, ringing in the ears, anxiety, confusion, headache, mood swings, sleep problems, or lethargic behavior. To prevent withdrawal, healthcare providers generally recommend that patients gradually taper their doses of paroxetine before stopping the medication completely⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paxil-paroxetine-hydrochloride-tablets-oral-suspension-prescribing-information\" data-reference-link=\"\" aria-label=\"Reference 4: FDA.gov. (2012, December). PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension Prescribing Information. FDA.gov. U.S. Food and Drug Administration. Accessed October 10 2026.\" data-reference-number=\"4\">[4]</a></sup>.\n</p><h3 id=\"what-s-the-difference-between-paroxetine-and-fluoxetine-paroxetine-and\">What’s the difference between paroxetine and fluoxetine?</h3><p>Paroxetine and <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/fluoxetine-uses-dosage-side-effects\">fluoxetine</a> are SSRIs. Response and side effects vary between individuals, so choosing a medicine requires consideration of symptoms, other health conditions, interactions, and past treatment. A prescriber can review whether an option is helping and adjust the plan when needed⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#fluoxetine-versus-sertraline-paroxetine-major-depression-tolerability-efficacy-anxious\" data-reference-link=\"\" aria-label=\"Reference 6: National Institute of Mental Health. (n.d.). Mental Health Medications. National Institutes of Health. National Institute of Mental Health. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a></sup>.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" data-reference-list=\"\" data-reference-style=\"author-date-title-source\" data-source-references=\"\" id=\"references\"><h2 id=\"references-2\">References</h2><ol><li id=\"statpearls-internet-treasure-island-fl-statpearls-publishing-2022-jan\" value=\"1\" data-reference-number=\"1\" data-reference-format=\"393\">Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). <em class=\"reference-title\">Paroxetine.</em> In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. <a href=\"https://www.ncbi.nlm.nih.gov/books/NBK526022/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-paroxetine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com#:~:text=Paroxetine%20is%20a%20selective%20serotonin,disorder%2C%20and%20premenstrual%20dysphoric%20disorder\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>.</li><li id=\"paroxetine-medlineplus-drug-information\" value=\"2\" data-reference-number=\"2\" data-reference-format=\"393\"><em class=\"reference-title\">Paroxetine: MedlinePlus Drug Information.</em> (n.d.). <a href=\"https://medlineplus.gov/druginfo/meds/a698032.html?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-paroxetine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com#:~:text=Paroxetine%20is%20in%20a%20class,that%20helps%20maintain%20mental%20balance\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">MedlinePlus</a>. Accessed October 10 2026.</li><li id=\"paroxetine-review\" value=\"3\" data-reference-number=\"3\" data-reference-format=\"393\">Bourin, M., Chue, P., &amp; Guillon, Y. (2006). <em class=\"reference-title\">Paroxetine: A review.</em> CNS Drug Reviews, 7(1), 25-47. <a href=\"https://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00189.x?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-paroxetine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">Wiley</a>. Accessed October 10 2026.</li><li id=\"paxil-paroxetine-hydrochloride-tablets-oral-suspension-prescribing-information\" value=\"4\" data-reference-number=\"4\" data-reference-format=\"393\">FDA.gov. (2012, December). <em class=\"reference-title\">PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension Prescribing Information.</em> FDA.gov. <a href=\"https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020031s067,020710s031.pdf?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-paroxetine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">U.S. Food and Drug Administration</a>. Accessed October 10 2026.</li><li id=\"paroxetine-paxil-nami-national-alliance-mental-illness\" value=\"5\" data-reference-number=\"5\" data-reference-format=\"393\"><em class=\"reference-title\">Paroxetine (Paxil) | NAMI: National Alliance on Mental Illness.</em> (n.d.). <a href=\"https://www.nami.org/treatments-and-approaches/mental-health-medications/types-of-medication/paroxetine-(paxil/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-paroxetine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">NAMI</a>. Accessed October 10 2026.</li><li id=\"fluoxetine-versus-sertraline-paroxetine-major-depression-tolerability-efficacy-anxious\" value=\"6\" data-reference-number=\"6\" data-reference-format=\"393\">National Institute of Mental Health. (n.d.). <em class=\"reference-title\">Mental Health Medications.</em> National Institutes of Health. <a href=\"https://www.nimh.nih.gov/health/topics/mental-health-medications?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-paroxetine-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Institute of Mental Health</a>. Accessed October 10 2026.</li></ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://www.mentalhealth.com/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://www.mentalhealth.com/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/jenni-jacobsen\" class=\"card-identity-photo\" aria-label=\"Jenni Jacobsen, Ph.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/4f4e4293be2246dfe2e00d7c.jpg\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Author</p><h3 id=\"jenni-jacobsen-ph-d\"><a href=\"https://www.mentalhealth.com/people/jenni-jacobsen\">Jenni Jacobsen, Ph.D.</a></h3><p class=\"article-bio-credentials\">Ph.D., LSW, MSW</p><p>Jenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-11-23T10:41:02Z\">November 23, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"card-identity-photo\" aria-label=\"Leila Khurshid, Pharm.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"leila-khurshid-pharm-d\"><a href=\"https://www.mentalhealth.com/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h3><p class=\"article-bio-credentials\">Pharm.D., BCPS</p><p>Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-11-23\">November 23, 2022</time></dd></div></dl></div></section></div></section><section aria-label=\"Related community\" class=\"article-topic-community article-topic-community-end\"><a href=\"https://www.mentalhealth.com/community/medications\" class=\"card-identity-photo\" aria-label=\"Medications\"><img alt=\"\" class=\"topic-community-banner\" height=\"675\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/f5e91a4297495afdb6431ec9.webp\" width=\"1199\" decoding=\"async\"></a><p class=\"topic-community-label\">Related community</p><h2><a href=\"https://www.mentalhealth.com/community/medications\">Medications</a></h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p></section></div></div><aside aria-label=\"Article navigation and related information\" class=\"article-sidebar\" data-bounded-rail=\"\" tabindex=\"0\"><details class=\"article-contents\" data-expanded=\"false\" data-scrolled-past=\"false\" data-section-preview=\"3\" open=\"\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a aria-label=\"Paroxetine brand names\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-brand-names\" title=\"Paroxetine brand names\">Paroxetine brand names</a></li><li><a aria-label=\"What is paroxetine prescribed for?\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#what-is-paroxetine-prescribed-for\" title=\"What is paroxetine prescribed for?\">What is paroxetine prescribed for?</a></li><li><a aria-label=\"How does paroxetine work?\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#how-does-paroxetine-work\" title=\"How does paroxetine work?\">How does paroxetine work?</a></li><li><a aria-label=\"How is paroxetine usually taken?\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#how-is-paroxetine-usually-taken\" title=\"How is paroxetine usually taken?\">How is paroxetine usually taken?</a></li><li><a aria-label=\"How long does paroxetine stay in your system?\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#how-long-does-paroxetine-stay-in-your-system\" title=\"How long does paroxetine stay in your system?\">How long does paroxetine stay in your system?</a></li><li><a aria-label=\"Paroxetine side effects\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-side-effects\" title=\"Paroxetine side effects\">Paroxetine side effects</a></li><li><a aria-label=\"Paroxetine precautions\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-precautions\" title=\"Paroxetine precautions\">Paroxetine precautions</a></li><li><a aria-label=\"Paroxetine drug interactions\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-drug-interactions\" title=\"Paroxetine drug interactions\">Paroxetine drug interactions</a></li><li><a aria-label=\"Paroxetine storage\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#paroxetine-storage\" title=\"Paroxetine storage\">Paroxetine storage</a></li><li><a aria-label=\"What to do if you overdose on paroxetine\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#what-to-do-if-you-overdose-on-paroxetine\" title=\"What to do if you overdose on paroxetine\">What to do if you overdose on paroxetine</a></li><li><a aria-label=\"Frequently asked questions about paroxetine\" href=\"https://www.mentalhealth.com/library/paroxetine-uses-dosage-side-effects#frequently-asked-questions-about-paroxetine\" title=\"Frequently asked questions about paroxetine\">Frequently asked questions about paroxetine</a></li></ol><button aria-controls=\"article-section-list\" aria-expanded=\"false\" class=\"article-sections-toggle\" data-sections-toggle=\"\" type=\"button\">View more</button></nav></details></aside></div></div></div>","text":"Home Library Medications Paroxetine (Paxil) Paroxetine (Paxil) Written by Jenni Jacobsen, Ph.D.Medically reviewed by Leila Khurshid, Pharm.D. Published on November 22, 2022 · Updated on November 23, 2025 Paroxetine, also known by its brand name of Paxil, is a selective serotonin reuptake inhibitor (SSRI). It is commonly used to treat depression but may also be used to treat anxiety disorders, including generalized anxiety disorder and social anxiety disorder⁠[1]. Key takeaways Paroxetine is an SSRI used for depression and several anxiety-related conditions. Paroxetine increases serotonin availability, and symptom improvement develops over time. Drug interactions, adverse effects, and symptoms after discontinuation require attention even though paroxetine is not generally considered addictive. Paroxetine brand names While paroxetine refers to the generic or chemical name of the medication, this drug can be sold under several brand names⁠[2]: Paxil Paxil CR Pexeva Brisdelle Subject matter expert Leila Khurshid, Pharm.D. Clinical pharmacy and medication View profile What is paroxetine prescribed for? As an antidepressant SSRI medication, paroxetine is most notable for its use in the treatment of depression. Other conditions that healthcare providers commonly prescribe paroxetine for include⁠[1]: Major depressive disorder (MDD) Obsessive-compulsive disorder (OCD) Social anxiety disorder (SAD) Panic disorder Post-traumatic stress disorder (PTSD) Generalized anxiety disorder (GAD) Premenstrual dysphoric disorder Menopausal symptoms like hot flashes Depression with bipolar disorder Paroxetine is not intended to be prescribed for children under 18, but some physicians may use it for teens and children with an obsessive-compulsive disorder or social anxiety disorder⁠[1]. Beyond the uses noted above, some less common uses of paroxetine are as follows⁠[1]: Separation anxiety disorder Dysthymia (persistent depression) Body dysmorphic disorder Postpartum depression Premature ejactulation How does paroxetine work? Paroxetine works by changing the availability of a neurotransmitter, or brain chemical, called serotonin. As a selective serotonin reuptake inhibitor (SSRI), paroxetine increases the availability of serotonin in the nervous system. This is important because low serotonin concentrations are believed to be involved in symptoms of depression, can help with anxiety symptoms such as panic attacks, and relieve symptoms of post-traumatic stress disorder⁠[1]. How is paroxetine usually taken? Paroxetine is taken orally, typically as a pill. In addition, it is available as a regular and extended-release tablet, which is released slowly into the body⁠[1]. Initial doses of paroxetine tablets are prescribed with a typical starting dose of 20 mg daily for depression. The daily dose may be increased by 10mg each week until a person reaches a dose of 50 mg per day. The extended-release pill is typically started at a dose of 25 mg per day, with an increase of 12.5 mg per day until a maximum dose of 62.5 mg daily is reached⁠[1]. Doses may vary slightly based on the condition for which paroxetine is prescribed. For instance, dosages for anxiety may vary from dosages for depression or other conditions. Doses may also be lower for individuals with kidney or liver problems. Your doctor can determine the best dose for your specific needs⁠[1]. How long does paroxetine stay in your system? Paroxetine has a half-life of 21 hours, meaning that every 21 hours, half of the concentration of the drug is removed from the body. Given this fact, paroxetine is completely eliminated from the system within about five days⁠[3]. Paroxetine side effects While paroxetine is an approved medication with legitimate medical uses, that does not mean that it is without side effects. The following common side effects with paroxetine use are generally considered to be mild but may still require medical advice⁠[2]: Problems concentrating Weakness or dizziness Headaches Confusion or forgetfulness Feelings of nervousness Sleepiness Gastrointestinal symptoms like nausea, vomiting, or diarrhea Gas and constipation Stomach pain Muscle and joint pain Dry mouth Reduced sex drive Changes in appetite Weight loss or gain Some of the more serious adverse effects of paroxetine include⁠[2]: Hallucinations Racing heart/irregular heartbeat Fainting Chest pain Seizures Breathing problems Uncoordinated walking/falling Abnormal bleeding or bruising Signs of infection, such as fever, chills, or cough Peeling or blistering skin Numbness in your legs, arms, hands, or feet Uncontrollable shaking in the body Hives, rash, or itching Bloody vomit or stools Swelling in the face or other parts of the body Painful erections lasting for hours Risk of serotonin syndrome Discontinuation syndrome While mild paroxetine side effects are manageable and will improve with time, you should seek immediate medical attention if you experience severe side effects. If you have continuous side effects that do not improve with time or that interfere significantly with daily life, talk with your doctor. Paroxetine precautions Before taking paroxetine, you should tell your doctor about any other health conditions or medications you are taking. Your doctor will determine whether any dose adjustments need to be made to accommodate your health problems. Your doctor may also choose a different medication if paroxetine could interact negatively with other prescriptions you are taking. Another precaution that comes along with paroxetine is the potential increased risk of suicidal thoughts. Children, teens, and young adults may experience increased suicidal thinking after being prescribed paroxetine. It is important to discuss this risk with your doctor and weigh the risks and benefits of taking the medication. Sometimes, the risk of not using paroxetine is greater than the risk of taking the medication, as untreated depression can also increase suicide risk⁠[2]. Paroxetine drug interactions As noted above, paroxetine may interact with other medications you are taking. Some medications that may interact negatively with paroxetine include⁠[4]: Tryptophan Pimozide Lithium Fentanyl Tramadol Thioridazine St. John’s wort Warfarin Phenobarbital Cimetidine Phenytoin Theophylline NSAIDs, like ibuprofen Fosamprenavir Ritonavir Digoxin Tricyclic antidepressants, like protriptyline, amitriptyline, and desipramine Atomoxetine Risperidone MAOIs, like selegiline, isocarboxazid, and phenelzine If you are also taking one of these medications, it may be unsafe for you to take paroxetine. Be sure to tell your doctor about all other medications you are taking, as paroxetine may interact with other prescription drugs not included on this list. Paroxetine storage Paroxetine should be stored in the original prescription container and kept at a temperature of 15-30 degrees Celsius or 59 to 86 degrees Fahrenheit⁠[4]. Failing to store paroxetine in the original container, with the prescription label, could result in someone accidentally taking a medication not intended for them, which can be dangerous. In addition, storing the medication at extreme temperatures can change some of the chemicals in the drug. What to do if you overdose on paroxetine Taking too large of a dose of paroxetine can result in an overdose. Some paroxetine overdose symptoms include⁠[2]: Drowsiness Seizures Coma Nausea, vomiting, or diarrhea Aggression Urine that is dark red or brown in color Extremely excited mood Elevated heart rate Severe twitching or stiffness of muscles Confusion Fever or sweating If you or a loved one experiences these symptoms while taking paroxetine, call the nearest Poison Control Center or report immediately to the local emergency room. A patient who collapses, has a seizure, cannot be awakened, or struggles to breathe requires emergency medical attention. Contact 911 immediately⁠[2]. Frequently asked questions about paroxetine The answers to the following common questions provide additional information about paroxetine. How long does it take for paroxetine to work? Everyone will respond differently to paroxetine, depending upon their unique medical history, symptom profile, and metabolism. People generally notice an improvement in sleep, appetite, and energy levels within a week or two of beginning paroxetine. Other symptoms may not improve immediately, including depressed mood and lack of pleasure with usual activities. It may take 6-8 weeks to experience the full benefits of paroxetine⁠[5]. Do not be discouraged if the medication does not immediately improve depression symptoms. Is paroxetine addictive? Paroxetine is generally not considered addictive in the same way that substances of abuse, such as cocaine or heroin, are addictive. However, people may become dependent upon the medication, meaning that the body does not function the same without it. This means abrupt discontinuation of paroxetine can lead to withdrawal side effects, like irritability, depressed mood, agitation, dizziness, ringing in the ears, anxiety, confusion, headache, mood swings, sleep problems, or lethargic behavior. To prevent withdrawal, healthcare providers generally recommend that patients gradually taper their doses of paroxetine before stopping the medication completely⁠[4]. What’s the difference between paroxetine and fluoxetine? Paroxetine and fluoxetine are SSRIs. Response and side effects vary between individuals, so choosing a medicine requires consideration of symptoms, other health conditions, interactions, and past treatment. A prescriber can review whether an option is helping and adjust the plan when needed⁠[6]. References Shrestha, P, Fariba, KA, Abdijadid, S. (2022, July 29). Paroxetine. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2022 Jan-. National Library of Medicine. Paroxetine: MedlinePlus Drug Information. (n.d.). MedlinePlus. Accessed October 10 2026. Bourin, M., Chue, P., & Guillon, Y. (2006). Paroxetine: A review. CNS Drug Reviews, 7(1), 25-47. Wiley. Accessed October 10 2026. FDA.gov. (2012, December). PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension Prescribing Information. FDA.gov. U.S. Food and Drug Administration. Accessed October 10 2026. Paroxetine (Paxil) | NAMI: National Alliance on Mental Illness. (n.d.). NAMI. Accessed October 10 2026. National Institute of Mental Health. (n.d.). Mental Health Medications. National Institutes of Health. National Institute of Mental Health. Accessed October 10 2026. Medical Content The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy. About MentalHealth.com MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life. Author Jenni Jacobsen, Ph.D. Ph.D., LSW, MSW Jenni Jacobsen, Ph.D. is a licensed social worker, behavioral health consultant and medical reviewer. She holds a Ph.D. in clinical psychology. Published November 22, 2022 Updated November 23, 2025 Medical Reviewer Leila Khurshid, Pharm.D. Pharm.D., BCPS Leila Khursid is a medical reviewer with a Doctor of Pharmacy degree and completed a PGY1 Pharmacy Residency from St. Mark's Hospital. Reviewed November 23, 2022 Related community Medications Explore questions and perspectives about psychiatric medications and the treatment experience. Table of contentsChoose a section Paroxetine brand names What is paroxetine prescribed for? How does paroxetine work? 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