{"formatVersion":"1.1","id":"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects","path":"/library/ziprasidone-uses-dosage-side-effects","url":"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects","title":"Ziprasidone (Geodon)","family":"Library detail","description":"Ziprasidone (Geodon) is an antipsychotic drug used to treat schizophrenia and bipolar mania. Learn more about how it is used, interactions, and more.","language":"en-US","access":{"audience":"public","indexable":true},"provenance":{"sourceUrl":"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects","wordpressId":"248","contentCompleteness":"complete","dateScope":"original-source"},"authors":[{"@type":"Person","@id":"https://www.mentalhealth.com/people/cristina-po-wenger#person","name":"Cristina Po Wenger","url":"https://www.mentalhealth.com/people/cristina-po-wenger"}],"reviewer":{"@type":"Person","@id":"https://www.mentalhealth.com/people/amy-shelby#person","name":"Amy Shelby","url":"https://www.mentalhealth.com/people/amy-shelby"},"dates":{"datePublished":"2022-11-22T19:00:00Z","dateModified":"2025-08-13T12:00:22Z","lastReviewed":"2022-11-23"},"content":{"html":"<nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\"><ol><li><a href=\"https://www.mentalhealth.com/\">Home</a></li><li><a href=\"https://www.mentalhealth.com/library\">Library</a></li><li><a href=\"https://www.mentalhealth.com/library/medications\">Medications</a></li><li><span aria-current=\"page\">Ziprasidone (Geodon)</span></li></ol></nav><div class=\"article-page article-standard\" data-library-standard=\"\"><div class=\"article-main-grid\"><header class=\"article-heading\"><h1>Ziprasidone (Geodon)</h1><p class=\"article-inline-credits\"><span class=\"credit-row\"><span>Written by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/cristina-po-wenger\">Cristina Po Wenger</a></span><span>Medically reviewed by <a class=\"article-credit-person\" href=\"https://www.mentalhealth.com/people/amy-shelby\">Amy Shelby, M.S.</a></span></span></p><div class=\"article-dates\"><span>Published on <time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></span><span aria-hidden=\"true\"> · </span><span>Updated on <time datetime=\"2025-08-13T12:00:22Z\">August 13, 2025</time></span></div></header><div class=\"article-jumpbar\"></div><div class=\"article-layout\"><div class=\"article-reading\"><article class=\"prose\" id=\"article-content\"><div class=\"article-intro\" data-source-field=\"hero\"><p>Ziprasidone is an atypical antipsychotic medicine. It is used in the treatment of schizophrenia, manic phases of bipolar disorder and acute agitation⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#systematic-review-case-series-ziprasidone-psychosis-parkinson-s-disease\" data-reference-link=\"\" aria-label=\"Reference 1: Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). 2019; 9(1):63-71. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>. It should not be used to treat symptoms of dementia in elderly patients. Before taking this medicine, consult your doctor, as this medicine interacts with other medications. It should also not be taken if you have heart problems.</p></div><figure class=\"article-feature\"><img alt=\"A counselor takes notes during a conversation with an adult.\" decoding=\"async\" height=\"600\" loading=\"eager\" src=\"https://www.mentalhealth.com/assets/optimized/7d897f0ee39d4329bfc5ebdf.webp\" width=\"1200\"></figure><section aria-labelledby=\"key-takeaways\" class=\"article-takeaways\"><h2 id=\"key-takeaways\">Key takeaways</h2><ul><li>Ziprasidone is an atypical antipsychotic used for schizophrenia, bipolar manic or mixed episodes, and some acute agitation.</li><li>Oral treatment is taken with food because food substantially increases absorption.</li><li>Heart rhythm risks, medication interactions, and other adverse effects require careful clinical assessment and monitoring.</li></ul></section><h2 id=\"ziprasidone-brand-names\">Ziprasidone brand names</h2><p>Ziprasidone is sold under the brand name Geodon.</p><h2 id=\"what-is-ziprasidone-prescribed-for\">What is ziprasidone prescribed for?</h2><p>Ziprasidone is prescribed in the treatment of symptoms of <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/schizophrenia\">schizophrenia</a> in adults, acute agitation in schizophrenic patients, and bipolar mania⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#systematic-review-case-series-ziprasidone-psychosis-parkinson-s-disease\" data-reference-link=\"\" aria-label=\"Reference 1: Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). 2019; 9(1):63-71. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><p>It is used as a monotherapy for adults with manic or mixed episodes of <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/bipolar-disorder\">bipolar disorder</a>. It is also used as a maintenance treatment for bipolar patients, in addition to lithium or valproate.</p><p>It is sometimes used as an off-label monotherapy medication for acute hypomania, hyperactivity, and <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/cognitive-disorders\">delirium</a> in intensive care units.</p><h2 id=\"how-does-ziprasidone-work\">How does ziprasidone work?</h2><p>Ziprasidone is an atypical or second-generation antipsychotic. It works by restoring the balance of certain natural substances in our brain (dopamine and serotonin), thus improving thoughts, mood, and behavior.</p><h2 id=\"how-is-ziprasidone-usually-taken\">How is ziprasidone usually taken?</h2><p>Ziprasidone is taken orally and as an intramuscular injection. The dose depends on the patient's needs and their response to the treatment. Always make sure to follow your doctor’s instructions.</p><p><strong>Oral intake: </strong>Ziprasidone is available in oral capsules of 20 mg, 40 mg, 60 mg, and 80 mg. </p><p>Schizophrenic patients will usually be advised to take 20mg twice per day with meals. The maximum dose should not be over 160 mg per day, 80 mg twice per day. Dosage can be adjusted at no fewer than two-day intervals.</p><p>For the treatment of bipolar disorder, patients will usually be advised to take an initial dose of 40 mg to 80 mg twice per day. Medication should be adjusted on the second day of treatment from 60 mg to 80 mg twice per day. </p><p>Capsules should not be opened or chewed, but swallowed whole and during high-caloric meals to ensure good absorption⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#impact-calories-fat-content-meals-oral-ziprasidone-absorption-randomised\" data-reference-link=\"\" aria-label=\"Reference 2: Gandelman K, Alderman JA, Glue P, Lombardo I, LaBadie RR, Versavel M, Preskorn SH. (2009). The impact of calories and fat content of meals on oral Ziprasidone absorption: A randomised, open-label, crossover trial. J Clin Psychiatry. 2009 Jan; 70(1):58-62. PubMed.\" data-reference-number=\"2\">[2]</a></sup>.</p><p><strong>Intramuscular injection: </strong>Administering ziprasidone via injection is used to quickly treat severe agitation or aggression in patients with bipolar disorder or schizophrenia, or to treat aggression derived from substance intoxication or other natural causes⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#pharmacological-treatment-major-depressive-episodes-mixed-features-systematic-review\" data-reference-link=\"\" aria-label=\"Reference 3: Shim IH, Bahk WM, Woo YS, Yoon BH. (2018). Pharmacological treatment of major depressive episodes with mixed features: A systematic review. Clin Psychopharmacol Neurosci. 2018 Nov 30; 16(4):376-382. National Library of Medicine.\" data-reference-number=\"3\">[3]</a></sup>.</p><ul><li>It is recommended to administer 10 mg to 20 mg with a maximum dose of 40 mg per day.</li><li>It should not be administered intravenously, only muscularly⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#ziprasidone-haloperidol-clonazepam-intramuscular-administration-treatment-agitation-symp\" data-reference-link=\"\" aria-label=\"Reference 4: Su L, Lu Z, Shi S, Xu Y. (2018). Ziprasidone, haloperidol and clonazepam intramuscular administration in the treatment of agitation symptoms in Chinese patients with schizophrenia: A network meta-analysis. Gen Psychiatr. 2018; 31(2):e000016. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"4\">[4]</a></sup>.</li></ul><h2 id=\"how-long-does-ziprasidone-stay-in-your-system\">How long does ziprasidone stay in your system?</h2><p>Ziprasidone stays in your system for 7-10 hours and is then eliminated via hepatic metabolism, through the liver⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#clinical-pharmacokinetics-atypical-antipsychotics-update\" data-reference-link=\"\" aria-label=\"Reference 5: Mauri MC, Paletta S, Di Pace C, Reggiori A, Cirnigliaro G, Valli I, Altamura AC. (2018). Clinical Pharmacokinetics of Atypical Antipsychotics: An Update. Clin Pharmacokinet. 2018 Dec;57(12):1493-1528. PubMed. Accessed October 10 2026.\" data-reference-number=\"5\">[5]</a></sup>.</p><h2 id=\"ziprasidone-side-effects\">Ziprasidone side effects</h2><p>Ziprasidone can cause multiple adverse effects. Common side effects include⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#systematic-review-case-series-ziprasidone-psychosis-parkinson-s-disease\" data-reference-link=\"\" aria-label=\"Reference 1: Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). 2019; 9(1):63-71. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>:</p><ul><li>dizziness, drowsiness, light-headedness</li><li><u>headache</u></li><li>nausea, vomiting</li><li>hyperglycemia (increase in blood sugar) </li></ul><p>Serious side effects are the following. If you notice any of these symptoms, you should stop taking ziprasidone and see your doctor immediately:</p><ul><li>fluttering in your chest, irregular heartbeat, or pounding</li><li>dizziness</li><li>difficulty breathing</li><li>fever</li><li>muscle stiffness</li><li>confusion or agitation</li><li>sores on the skin or in the mouth</li><li>cough</li><li>increased thirst and urination and a dry mouth</li><li>heavy sweating</li></ul><p>Patients are also at risk of neuroleptic malignant syndrome⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#case-report-ziprasidone-induced-neuroleptic-malignant-syndrome\" data-reference-link=\"\" aria-label=\"Reference 6: Sedhai YR, Atreya A, Phuyal P, Basnyat S, Pokhrel S. (1000). Case Report: Ziprasidone induced neuroleptic malignant syndrome. F1000Res. 2021; 10:124. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"6\">[6]</a></sup>. If you have stiff muscles, high fever, high or low blood pressure, difficulty in breathing, or heavy sweating, see a doctor immediately.</p><p>Stop taking the medicine and seek medical advice if you notice symptoms of an allergy or reaction after starting the medicine, such as hives, difficulty breathing, swelling, allergic skin reactions, rash, eye and throat irritation, or fever. These may be symptoms of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), which is extremely rare but has been related to ziprasidone exposure⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#systematic-review-case-series-ziprasidone-psychosis-parkinson-s-disease\" data-reference-link=\"\" aria-label=\"Reference 1: Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). 2019; 9(1):63-71. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><p>Treatment with ziprasidone may also lead to tardive dyskinesia, a condition characterized by repetitive, involuntary facial muscle movements. If dyskinesia is suspected, stop taking the medication and see your doctor immediately⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#knowledge-pharmacology-antidepressants-antipsychotics-yields-results-comparable-pharmaco\" data-reference-link=\"\" aria-label=\"Reference 7: Macaluso M, Preskorn SH. (2018). Knowledge of the pharmacology of antidepressants and antipsychotics yields results comparable with pharmacogenetic testing. J Psychiatr Pract. 2018 Nov; 24(6):416-419. PubMed. Accessed October 10 2026.\" data-reference-number=\"7\">[7]</a></sup>.</p><p>Finally, antipsychotic drugs can cause motor and sensory instability, leading to falls and accidents, which may result in fractures or other injuries. </p><p>This is not a complete list of ziprasidone side effects. If in doubt, consult your doctor.</p><h2 id=\"ziprasidone-precautions\">Ziprasidone precautions</h2><p>Before taking ziprasidone, thoroughly inform your doctor of any pre-existing medical conditions and on your own and your family’s medical history, especially related to heart disease, diabetes, low white blood cell count, <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/dementia\">dementia</a>, obesity, sleep apnea, difficulty swallowing, low levels of potassium or magnesium, or seizures.</p><p>It is important to discuss any risks and benefits of treatment with your medical professional before you begin taking ziprasidone or other antipsychotic medication.</p><p>Precautions should be taken regarding the following situations:</p><p><strong>Patients with diabetes mellitus or with a family history of diabetes</strong>: Patients should be monitored daily when taking ziprasidone, and should do so with caution⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#drug-induced-diabetes-mellitus-example-atypical-antipsychotics\" data-reference-link=\"\" aria-label=\"Reference 8: Scheen AJ, De Hert M. (2005). [Drug-induced diabetes mellitus: the example of atypical antipsychotics]. Rev Med Liege. 2005 May-Jun; 60(5-6):455-60. PubMed.\" data-reference-number=\"8\">[8]</a></sup>.</p><p><strong>Patients over 65 years old that suffer from dementia-related psychosis</strong>: Patients should not be treated with Ziprasidone, as it is associated with cognitive decline, an increased risk of stroke, and an increased risk of death⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#systematic-review-case-series-ziprasidone-psychosis-parkinson-s-disease\" data-reference-link=\"\" aria-label=\"Reference 1: Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). 2019; 9(1):63-71. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"1\">[1]</a></sup>.</p><p><strong>Patients with heart problems or with a family history of heart disease</strong>: Patients should inform their doctor if they or people in their family have a history of heart rhythm problems, slow heartbeat, heart disease, cardiac death, or heart attacks; Ziprasidone causes QT prolongation, a condition that affects the heart’s rhythm, leading to irregular heartbeat, fainting, dizziness, and other very severe afflictions. </p><p>Even if you have no heart disease history, let your doctor know if you are taking any other medication, as this can increase your risk of QT prolongation⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#effects-atypical-antipsychotic-drugs-qt-interval-patients-mental-disorders\" data-reference-link=\"\" aria-label=\"Reference 9: Aronow WS, Shamliyan TA. (2018). Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders. Ann Transl Med. 2018 Apr; 6(8):147. National Library of Medicine. Accessed October 10 2026.\" data-reference-number=\"9\">[9]</a></sup>.</p><p><strong>Patients with low white blood cells</strong>: Patients should inform their doctor and monitor their blood count during the first two months of treatment with ziprasidone, as its intake causes the risk of leukopenia, neutropenia, and agranulocytosis. </p><p>Ziprasidone may also cause dizziness or drowsiness so make sure you know how you react to the drug before you drive or operate heavy machinery. </p><p>If you are pregnant or suspect pregnancy, please inform your doctor, as alternative medication with a better safety profile is preferred⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#world-federation-societies-biological-psychiatry-wfsbp-guidelines-biological-treatment\" data-reference-link=\"\" aria-label=\"Reference 10: Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW, Azorin JM, Yatham L, Mosolov S, Möller HJ, Kasper S., Members of the WFSBP task force on bipolar affective disorders working on this topic. (2018). The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder. World J Biol Psychiatry. 2018 Feb; 19(1):2-58. PubMed.\" data-reference-number=\"10\">[10]</a></sup>.</p><p>If you are currently breastfeeding, please take ziprasidone with caution, as infants exposed to the drug via breastfeeding may suffer from a number of side-effects, such as poor feeding, excess sedation, or abnormal muscle movements⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#danish-society-obstetrics-gynecology\" data-reference-link=\"\" aria-label=\"Reference 11: Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P., Danish Psychiatric Society. (2015). Danish Society of Obstetrics and Gynecology. Danish Paediatric Society. Danish Society of Clinical Pharmacology. Use of psychotropic drugs during pregnancy and breast-feeding. Acta Psychiatr Scand Suppl. 2015;(445):1-28. PubMed.\" data-reference-number=\"11\">[11]</a></sup>.</p><p>Treatment with ziprasidone is long term; therefore, do not stop taking it even though you feel well, as interrupting the treatment or skipping doses may risk a relapse in symptoms. Take ziprasidone as ordered by your doctor to ensure it works properly.</p><h2 id=\"ziprasidone-interactions\">Ziprasidone interactions</h2><p>Ziprasidone should not be taken with any other drug that prolongs the QT interval⁠<sup class=\"citation-group\"><a class=\"article-citation\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#labeling-pfizer-com\" data-reference-link=\"\" aria-label=\"Reference 12: Pfizer U.S. Pharmaceuticals Group. (2001). Geodon (ziprasidone): Product information. labeling.pfizer.com. Accessed October 10 2026.\" data-reference-number=\"12\">[12]</a></sup>. Do not take ziprasidone if you are taking any of the following medications, as they may cause severe adverse reactions.</p><ul><li>Amiodarone (Cordarone)</li><li>Arsenic trioxide (Trisenox)</li><li><a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/chlorpromazine-use-dosage-warnings-effects\">Chlorpromazine</a> (Thorazine)</li><li>Disopyramide (Norpace)</li><li>Dofetilide (Tikosyn)</li><li>Dolasetron mesylate (Anzemet)</li><li>Droperidol (Inapsine)</li><li>Gatifloxacin (Tequin)</li><li>Halofantrine</li><li>Levomethadyl acetate,</li><li>Mefloquine (Lariam)</li><li>Mesoridazine (Serentil)</li><li>Moxifloxacin (Avelox)</li><li>Pentamidine (Nebupent)</li><li>Pimozide (Orap)</li><li>Probucol</li><li>Procainamide (Pronestyl)</li><li>Quinidine (Cardioquin)</li><li>Sotalol (Betapase)</li><li>Sparfloxacin (Zagam)</li><li>Tacrolimus (Prograf)</li><li>Thioridazine (Mellaril)</li></ul><p>This is not an exhaustive list; please consult your healthcare provider to discuss further. </p><p>Patients taking medication that acts on the central nervous system should also not use ziprasidone, as there is the potential of additive adverse reaction.</p><p>Remember to always inform your doctor of any other medication you might be taking, including non-prescription medication, herbal or alternative medicine, nutritional supplements, and vitamins. </p><p>Make sure to inform your healthcare provider if you are using antidepressants, anxiety medication, <a class=\"article-inline-link\" href=\"https://www.mentalhealth.com/library/carbamazepine-uses-dosage-effects\">carbamazepine</a>, diuretics, dopamine agonists, ketoconazole, medication for high blood pressure, mental illness, seizures, or anxiety, sedatives, sleeping pills, or tranquillisers. </p><p>Finally, avoid consuming alcohol while using ziprasidone.</p><h2 id=\"ziprasidone-storage\">Ziprasidone storage</h2><p>Ziprasidone should not be exposed to heat, light, or humidity, and should be stored in its original container at room temperature, provided it does not exceed 30°C (86 F) and is kept out of the reach of children.</p><p>Ask your pharmacist for proper disposal of leftover or expired medication, avoiding risks to public health and the environment.</p><section aria-label=\"Subject matter expert\" class=\"article-expert article-expert-inline\" data-expert-kind=\"related\" data-expert-layout=\"standard\"><p class=\"article-bio-role\">Subject matter expert</p><div class=\"article-expert-identity\"><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"card-identity-photo\" aria-label=\"Leila Khurshid, Pharm.D.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/90339bb61ace127cee8df5f2.webp\" width=\"64\" decoding=\"async\"></a><h2><a href=\"https://www.mentalhealth.com/people/leila-khurshid\">Leila Khurshid, Pharm.D.</a></h2></div><p class=\"article-expert-focus\">Clinical pharmacy and medication</p><a href=\"https://www.mentalhealth.com/people/leila-khurshid\" class=\"quiet-button\">View profile</a></section><h2 id=\"what-to-do-if-you-overdose-on-ziprasidone\">What to do if you overdose on ziprasidone</h2><p>If you overdose on ziprasidone, seek immediate medical care. If the patient presents symptoms of overdose such as collapse, seizures, or trouble breathing, call your emergency services immediately.</p><p>There is no specific treatment to reverse the effects of a ziprasidone overdose.</p><h2 id=\"faqs\">FAQs</h2><h3 id=\"how-long-does-it-take-for-ziprasidone-to-work\">How long does it take for ziprasidone to work?</h3><p>Ziprasidone should always be taken with food, as its absorption is increased twofold. After administration, it reaches peak plasma concentrations in 6-8 hours.</p><h3 id=\"who-makes-ziprasidone\">Who makes ziprasidone?</h3><p>Ziprasidone is produced by Pfizer under the brand name Geodon.</p><h3 id=\"what-do-i-do-if-i-miss-a-dose\">What do I do if I miss a dose?</h3><p>If you miss a dose, take it as soon as possible. However, if it is near the time for the next dose, skip the missed dose. Do not double the dose.</p><h3 id=\"what-supplements-interact-with-ziprasidone\">What supplements interact with ziprasidone?</h3><p>Using melatonin whilst being treated with ziprasidone might increase side effects, such as difficulty concentrating, dizziness or drowsiness. It might also affect judgement, thinking, and motor coordination, especially in elderly patients.</p></article><div class=\"article-endmatter\"><section class=\"article-sources\" data-reference-list=\"\" data-reference-style=\"author-date-title-source\" data-source-references=\"\" id=\"references\"><h2 id=\"references-2\">References</h2><ol><li id=\"systematic-review-case-series-ziprasidone-psychosis-parkinson-s-disease\" value=\"1\" data-reference-number=\"1\" data-reference-format=\"393\">Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). <em class=\"reference-title\">2019; 9(1):63-71.</em> <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6398550/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>. Accessed October 10 2026.</li><li id=\"impact-calories-fat-content-meals-oral-ziprasidone-absorption-randomised\" value=\"2\" data-reference-number=\"2\" data-reference-format=\"393\">Gandelman K, Alderman JA, Glue P, Lombardo I, LaBadie RR, Versavel M, Preskorn SH. (2009). <em class=\"reference-title\">The impact of calories and fat content of meals on oral Ziprasidone absorption: A randomised, open-label, crossover trial. J Clin Psychiatry.</em> 2009 Jan; 70(1):58-62. <a href=\"https://pubmed.ncbi.nlm.nih.gov/19026256/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>.</li><li id=\"pharmacological-treatment-major-depressive-episodes-mixed-features-systematic-review\" value=\"3\" data-reference-number=\"3\" data-reference-format=\"393\">Shim IH, Bahk WM, Woo YS, Yoon BH. (2018). <em class=\"reference-title\">Pharmacological treatment of major depressive episodes with mixed features: A systematic review.</em> Clin Psychopharmacol Neurosci. 2018 Nov 30; 16(4):376-382. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6245291/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>.</li><li id=\"ziprasidone-haloperidol-clonazepam-intramuscular-administration-treatment-agitation-symp\" value=\"4\" data-reference-number=\"4\" data-reference-format=\"393\">Su L, Lu Z, Shi S, Xu Y. (2018). <em class=\"reference-title\">Ziprasidone, haloperidol and clonazepam intramuscular administration in the treatment of agitation symptoms in Chinese patients with schizophrenia: A network meta-analysis.</em> Gen Psychiatr. 2018; 31(2):e000016. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC6234964/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>. Accessed October 10 2026.</li><li id=\"clinical-pharmacokinetics-atypical-antipsychotics-update\" value=\"5\" data-reference-number=\"5\" data-reference-format=\"393\">Mauri MC, Paletta S, Di Pace C, Reggiori A, Cirnigliaro G, Valli I, Altamura AC. (2018). <em class=\"reference-title\">Clinical Pharmacokinetics of Atypical Antipsychotics: An Update.</em> Clin Pharmacokinet. 2018 Dec;57(12):1493-1528. <a href=\"https://pubmed.ncbi.nlm.nih.gov/29915922/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>. Accessed October 10 2026.</li><li id=\"case-report-ziprasidone-induced-neuroleptic-malignant-syndrome\" value=\"6\" data-reference-number=\"6\" data-reference-format=\"393\">Sedhai YR, Atreya A, Phuyal P, Basnyat S, Pokhrel S. (1000). <em class=\"reference-title\">Case Report: Ziprasidone induced neuroleptic malignant syndrome.</em> F1000Res. 2021; 10:124. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC7953912/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>. Accessed October 10 2026.</li><li id=\"knowledge-pharmacology-antidepressants-antipsychotics-yields-results-comparable-pharmaco\" value=\"7\" data-reference-number=\"7\" data-reference-format=\"393\">Macaluso M, Preskorn SH. (2018). <em class=\"reference-title\">Knowledge of the pharmacology of antidepressants and antipsychotics yields results comparable with pharmacogenetic testing. J Psychiatr Pract.</em> 2018 Nov; 24(6):416-419. <a href=\"https://pubmed.ncbi.nlm.nih.gov/30395549/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>. Accessed October 10 2026.</li><li id=\"drug-induced-diabetes-mellitus-example-atypical-antipsychotics\" value=\"8\" data-reference-number=\"8\" data-reference-format=\"393\">Scheen AJ, De Hert M. (2005). <em class=\"reference-title\">[Drug-induced diabetes mellitus: the example of atypical antipsychotics].</em> Rev Med Liege. 2005 May-Jun; 60(5-6):455-60. <a href=\"https://pubmed.ncbi.nlm.nih.gov/16035311/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>.</li><li id=\"effects-atypical-antipsychotic-drugs-qt-interval-patients-mental-disorders\" value=\"9\" data-reference-number=\"9\" data-reference-format=\"393\">Aronow WS, Shamliyan TA. (2018). <em class=\"reference-title\">Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders.</em> Ann Transl Med. 2018 Apr; 6(8):147. <a href=\"https://pmc.ncbi.nlm.nih.gov/articles/PMC5952011/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">National Library of Medicine</a>. Accessed October 10 2026.</li><li id=\"world-federation-societies-biological-psychiatry-wfsbp-guidelines-biological-treatment\" value=\"10\" data-reference-number=\"10\" data-reference-format=\"393\">Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW, Azorin JM, Yatham L, Mosolov S, Möller HJ, Kasper S., Members of the WFSBP task force on bipolar affective disorders working on this topic. (2018). <em class=\"reference-title\">The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder.</em> World J Biol Psychiatry. 2018 Feb; 19(1):2-58. <a href=\"https://pubmed.ncbi.nlm.nih.gov/29098925/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>.</li><li id=\"danish-society-obstetrics-gynecology\" value=\"11\" data-reference-number=\"11\" data-reference-format=\"393\">Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P., Danish Psychiatric Society. (2015). <em class=\"reference-title\">Danish Society of Obstetrics and Gynecology.</em> Danish Paediatric Society. Danish Society of Clinical Pharmacology. Use of psychotropic drugs during pregnancy and breast-feeding. Acta Psychiatr Scand Suppl. 2015;(445):1-28. <a href=\"https://pubmed.ncbi.nlm.nih.gov/26344706/?utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">PubMed</a>.</li><li id=\"labeling-pfizer-com\" value=\"12\" data-reference-number=\"12\" data-reference-format=\"393\">Pfizer U.S. Pharmaceuticals Group. (2001). <em class=\"reference-title\">Geodon (ziprasidone): Product information.</em> <a href=\"https://labeling.pfizer.com/showlabeling.aspx?id=584&amp;utm_medium=referral&amp;utm_campaign=libra&amp;utm_content=external_resource&amp;utm_id=site-library-ziprasidone-uses-dosage-side-effects&amp;utm_source=mentalhealth.com\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" class=\"reference-source\">labeling.pfizer.com</a>. Accessed October 10 2026.</li></ol></section><section class=\"article-medical article-panel\"><h2 id=\"medical-content\">Medical Content</h2><p><a href=\"https://www.mentalhealth.com/clinical-affairs\">The Clinical Affairs Team</a> at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the <a href=\"https://www.mentalhealth.com/publishing/editorial-policy\">Editorial Policy</a>.</p></section><section class=\"article-about article-panel\"><h2 id=\"about-mentalhealth-com\">About MentalHealth.com</h2><p>MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life.</p><div class=\"article-contributors\"><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/cristina-po-wenger\" class=\"card-identity-photo\" aria-label=\"Cristina Po Wenger\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/0750b49782b2b8f839e63006.webp\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Author</p><h3 id=\"cristina-po-wenger\"><a href=\"https://www.mentalhealth.com/people/cristina-po-wenger\">Cristina Po Wenger</a></h3><p class=\"article-bio-credentials\">Writer</p><p>Cristina Po Wenger is a medical writer and mental health advocate with a Sociology Degree from the University of Stirling.</p><dl><div><dt>Published</dt><dd><time datetime=\"2022-11-22T19:00:00Z\">November 22, 2022</time></dd></div><div><dt>Updated</dt><dd><time datetime=\"2025-08-13T12:00:22Z\">August 13, 2025</time></dd></div></dl></div></section><section class=\"article-bio\"><a href=\"https://www.mentalhealth.com/people/amy-shelby\" class=\"card-identity-photo\" aria-label=\"Amy Shelby, M.S.\"><img alt=\"\" height=\"64\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/21afa080123d8c48701b6218.jpg\" width=\"64\" decoding=\"async\"></a><div><p class=\"article-bio-role\">Medical Reviewer</p><h3 id=\"amy-shelby\"><a href=\"https://www.mentalhealth.com/people/amy-shelby\">Amy Shelby, M.S.</a></h3><p class=\"article-bio-credentials\">M.S. Counseling Psychology</p><p>Amy Shelby is a medical reviewer with a B.A. in Psychology from Northwestern and an M.S. in Psychology from Chatham University.</p><dl><div><dt>Reviewed</dt><dd><time datetime=\"2022-11-23\">November 23, 2022</time></dd></div></dl></div></section></div></section><section aria-label=\"Related community\" class=\"article-topic-community article-topic-community-end\"><a href=\"https://www.mentalhealth.com/community/medications\" class=\"card-identity-photo\" aria-label=\"Medications\"><img alt=\"\" class=\"topic-community-banner\" height=\"675\" loading=\"lazy\" src=\"https://www.mentalhealth.com/assets/optimized/f5e91a4297495afdb6431ec9.webp\" width=\"1199\" decoding=\"async\"></a><p class=\"topic-community-label\">Related community</p><h2><a href=\"https://www.mentalhealth.com/community/medications\">Medications</a></h2><p>Explore questions and perspectives about psychiatric medications and the treatment experience.</p></section></div></div><aside aria-label=\"Article navigation and related information\" class=\"article-sidebar\" data-bounded-rail=\"\" tabindex=\"0\"><details class=\"article-contents\" data-expanded=\"false\" data-scrolled-past=\"false\" data-section-preview=\"3\" open=\"\"><summary><strong>Table of contents</strong><span aria-hidden=\"true\"></span><small data-current-section=\"\">Choose a section</small></summary><nav aria-label=\"Article contents\"><ol id=\"article-section-list\"><li><a aria-label=\"Ziprasidone brand names\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#ziprasidone-brand-names\" title=\"Ziprasidone brand names\">Ziprasidone brand names</a></li><li><a aria-label=\"What is ziprasidone prescribed for?\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#what-is-ziprasidone-prescribed-for\" title=\"What is ziprasidone prescribed for?\">What is ziprasidone prescribed for?</a></li><li><a aria-label=\"How does ziprasidone work?\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#how-does-ziprasidone-work\" title=\"How does ziprasidone work?\">How does ziprasidone work?</a></li><li><a aria-label=\"How is ziprasidone usually taken?\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#how-is-ziprasidone-usually-taken\" title=\"How is ziprasidone usually taken?\">How is ziprasidone usually taken?</a></li><li><a aria-label=\"How long does ziprasidone stay in your system?\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#how-long-does-ziprasidone-stay-in-your-system\" title=\"How long does ziprasidone stay in your system?\">How long does ziprasidone stay in your system?</a></li><li><a aria-label=\"Ziprasidone side effects\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#ziprasidone-side-effects\" title=\"Ziprasidone side effects\">Ziprasidone side effects</a></li><li><a aria-label=\"Ziprasidone precautions\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#ziprasidone-precautions\" title=\"Ziprasidone precautions\">Ziprasidone precautions</a></li><li><a aria-label=\"Ziprasidone interactions\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#ziprasidone-interactions\" title=\"Ziprasidone interactions\">Ziprasidone interactions</a></li><li><a aria-label=\"Ziprasidone storage\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#ziprasidone-storage\" title=\"Ziprasidone storage\">Ziprasidone storage</a></li><li><a aria-label=\"What to do if you overdose on ziprasidone\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#what-to-do-if-you-overdose-on-ziprasidone\" title=\"What to do if you overdose on ziprasidone\">What to do if you overdose on ziprasidone</a></li><li><a aria-label=\"FAQs\" href=\"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#faqs\" title=\"FAQs\">FAQs</a></li></ol><button aria-controls=\"article-section-list\" aria-expanded=\"false\" class=\"article-sections-toggle\" data-sections-toggle=\"\" type=\"button\">View more</button></nav></details></aside></div></div></div>","text":"Home Library Medications Ziprasidone (Geodon) Ziprasidone (Geodon) Written by Cristina Po WengerMedically reviewed by Amy Shelby, M.S. Published on November 22, 2022 · Updated on August 13, 2025 Ziprasidone is an atypical antipsychotic medicine. It is used in the treatment of schizophrenia, manic phases of bipolar disorder and acute agitation⁠[1]. It should not be used to treat symptoms of dementia in elderly patients. Before taking this medicine, consult your doctor, as this medicine interacts with other medications. It should also not be taken if you have heart problems. Key takeaways Ziprasidone is an atypical antipsychotic used for schizophrenia, bipolar manic or mixed episodes, and some acute agitation. Oral treatment is taken with food because food substantially increases absorption. Heart rhythm risks, medication interactions, and other adverse effects require careful clinical assessment and monitoring. Ziprasidone brand names Ziprasidone is sold under the brand name Geodon. What is ziprasidone prescribed for? Ziprasidone is prescribed in the treatment of symptoms of schizophrenia in adults, acute agitation in schizophrenic patients, and bipolar mania⁠[1]. It is used as a monotherapy for adults with manic or mixed episodes of bipolar disorder. It is also used as a maintenance treatment for bipolar patients, in addition to lithium or valproate. It is sometimes used as an off-label monotherapy medication for acute hypomania, hyperactivity, and delirium in intensive care units. How does ziprasidone work? Ziprasidone is an atypical or second-generation antipsychotic. It works by restoring the balance of certain natural substances in our brain (dopamine and serotonin), thus improving thoughts, mood, and behavior. How is ziprasidone usually taken? Ziprasidone is taken orally and as an intramuscular injection. The dose depends on the patient's needs and their response to the treatment. Always make sure to follow your doctor’s instructions. Oral intake: Ziprasidone is available in oral capsules of 20 mg, 40 mg, 60 mg, and 80 mg. Schizophrenic patients will usually be advised to take 20mg twice per day with meals. The maximum dose should not be over 160 mg per day, 80 mg twice per day. Dosage can be adjusted at no fewer than two-day intervals. For the treatment of bipolar disorder, patients will usually be advised to take an initial dose of 40 mg to 80 mg twice per day. Medication should be adjusted on the second day of treatment from 60 mg to 80 mg twice per day. Capsules should not be opened or chewed, but swallowed whole and during high-caloric meals to ensure good absorption⁠[2]. Intramuscular injection: Administering ziprasidone via injection is used to quickly treat severe agitation or aggression in patients with bipolar disorder or schizophrenia, or to treat aggression derived from substance intoxication or other natural causes⁠[3]. It is recommended to administer 10 mg to 20 mg with a maximum dose of 40 mg per day. It should not be administered intravenously, only muscularly⁠[4]. How long does ziprasidone stay in your system? Ziprasidone stays in your system for 7-10 hours and is then eliminated via hepatic metabolism, through the liver⁠[5]. Ziprasidone side effects Ziprasidone can cause multiple adverse effects. Common side effects include⁠[1]: dizziness, drowsiness, light-headedness headache nausea, vomiting hyperglycemia (increase in blood sugar) Serious side effects are the following. If you notice any of these symptoms, you should stop taking ziprasidone and see your doctor immediately: fluttering in your chest, irregular heartbeat, or pounding dizziness difficulty breathing fever muscle stiffness confusion or agitation sores on the skin or in the mouth cough increased thirst and urination and a dry mouth heavy sweating Patients are also at risk of neuroleptic malignant syndrome⁠[6]. If you have stiff muscles, high fever, high or low blood pressure, difficulty in breathing, or heavy sweating, see a doctor immediately. Stop taking the medicine and seek medical advice if you notice symptoms of an allergy or reaction after starting the medicine, such as hives, difficulty breathing, swelling, allergic skin reactions, rash, eye and throat irritation, or fever. These may be symptoms of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), which is extremely rare but has been related to ziprasidone exposure⁠[1]. Treatment with ziprasidone may also lead to tardive dyskinesia, a condition characterized by repetitive, involuntary facial muscle movements. If dyskinesia is suspected, stop taking the medication and see your doctor immediately⁠[7]. Finally, antipsychotic drugs can cause motor and sensory instability, leading to falls and accidents, which may result in fractures or other injuries. This is not a complete list of ziprasidone side effects. If in doubt, consult your doctor. Ziprasidone precautions Before taking ziprasidone, thoroughly inform your doctor of any pre-existing medical conditions and on your own and your family’s medical history, especially related to heart disease, diabetes, low white blood cell count, dementia, obesity, sleep apnea, difficulty swallowing, low levels of potassium or magnesium, or seizures. It is important to discuss any risks and benefits of treatment with your medical professional before you begin taking ziprasidone or other antipsychotic medication. Precautions should be taken regarding the following situations: Patients with diabetes mellitus or with a family history of diabetes: Patients should be monitored daily when taking ziprasidone, and should do so with caution⁠[8]. Patients over 65 years old that suffer from dementia-related psychosis: Patients should not be treated with Ziprasidone, as it is associated with cognitive decline, an increased risk of stroke, and an increased risk of death⁠[1]. Patients with heart problems or with a family history of heart disease: Patients should inform their doctor if they or people in their family have a history of heart rhythm problems, slow heartbeat, heart disease, cardiac death, or heart attacks; Ziprasidone causes QT prolongation, a condition that affects the heart’s rhythm, leading to irregular heartbeat, fainting, dizziness, and other very severe afflictions. Even if you have no heart disease history, let your doctor know if you are taking any other medication, as this can increase your risk of QT prolongation⁠[9]. Patients with low white blood cells: Patients should inform their doctor and monitor their blood count during the first two months of treatment with ziprasidone, as its intake causes the risk of leukopenia, neutropenia, and agranulocytosis. Ziprasidone may also cause dizziness or drowsiness so make sure you know how you react to the drug before you drive or operate heavy machinery. If you are pregnant or suspect pregnancy, please inform your doctor, as alternative medication with a better safety profile is preferred⁠[10]. If you are currently breastfeeding, please take ziprasidone with caution, as infants exposed to the drug via breastfeeding may suffer from a number of side-effects, such as poor feeding, excess sedation, or abnormal muscle movements⁠[11]. Treatment with ziprasidone is long term; therefore, do not stop taking it even though you feel well, as interrupting the treatment or skipping doses may risk a relapse in symptoms. Take ziprasidone as ordered by your doctor to ensure it works properly. Ziprasidone interactions Ziprasidone should not be taken with any other drug that prolongs the QT interval⁠[12]. Do not take ziprasidone if you are taking any of the following medications, as they may cause severe adverse reactions. Amiodarone (Cordarone) Arsenic trioxide (Trisenox) Chlorpromazine (Thorazine) Disopyramide (Norpace) Dofetilide (Tikosyn) Dolasetron mesylate (Anzemet) Droperidol (Inapsine) Gatifloxacin (Tequin) Halofantrine Levomethadyl acetate, Mefloquine (Lariam) Mesoridazine (Serentil) Moxifloxacin (Avelox) Pentamidine (Nebupent) Pimozide (Orap) Probucol Procainamide (Pronestyl) Quinidine (Cardioquin) Sotalol (Betapase) Sparfloxacin (Zagam) Tacrolimus (Prograf) Thioridazine (Mellaril) This is not an exhaustive list; please consult your healthcare provider to discuss further. Patients taking medication that acts on the central nervous system should also not use ziprasidone, as there is the potential of additive adverse reaction. Remember to always inform your doctor of any other medication you might be taking, including non-prescription medication, herbal or alternative medicine, nutritional supplements, and vitamins. Make sure to inform your healthcare provider if you are using antidepressants, anxiety medication, carbamazepine, diuretics, dopamine agonists, ketoconazole, medication for high blood pressure, mental illness, seizures, or anxiety, sedatives, sleeping pills, or tranquillisers. Finally, avoid consuming alcohol while using ziprasidone. Ziprasidone storage Ziprasidone should not be exposed to heat, light, or humidity, and should be stored in its original container at room temperature, provided it does not exceed 30°C (86 F) and is kept out of the reach of children. Ask your pharmacist for proper disposal of leftover or expired medication, avoiding risks to public health and the environment. Subject matter expert Leila Khurshid, Pharm.D. Clinical pharmacy and medication View profile What to do if you overdose on ziprasidone If you overdose on ziprasidone, seek immediate medical care. If the patient presents symptoms of overdose such as collapse, seizures, or trouble breathing, call your emergency services immediately. There is no specific treatment to reverse the effects of a ziprasidone overdose. FAQs How long does it take for ziprasidone to work? Ziprasidone should always be taken with food, as its absorption is increased twofold. After administration, it reaches peak plasma concentrations in 6-8 hours. Who makes ziprasidone? Ziprasidone is produced by Pfizer under the brand name Geodon. What do I do if I miss a dose? If you miss a dose, take it as soon as possible. However, if it is near the time for the next dose, skip the missed dose. Do not double the dose. What supplements interact with ziprasidone? Using melatonin whilst being treated with ziprasidone might increase side effects, such as difficulty concentrating, dizziness or drowsiness. It might also affect judgement, thinking, and motor coordination, especially in elderly patients. References Younce JR, Davis AA, Black KJ. A systematic review and case series of Ziprasidone for psychosis in Parkinson's Disease. J Parkinsons Dis. (n.d.). 2019; 9(1):63-71. National Library of Medicine. Accessed October 10 2026. Gandelman K, Alderman JA, Glue P, Lombardo I, LaBadie RR, Versavel M, Preskorn SH. (2009). The impact of calories and fat content of meals on oral Ziprasidone absorption: A randomised, open-label, crossover trial. J Clin Psychiatry. 2009 Jan; 70(1):58-62. PubMed. Shim IH, Bahk WM, Woo YS, Yoon BH. (2018). Pharmacological treatment of major depressive episodes with mixed features: A systematic review. Clin Psychopharmacol Neurosci. 2018 Nov 30; 16(4):376-382. National Library of Medicine. Su L, Lu Z, Shi S, Xu Y. (2018). Ziprasidone, haloperidol and clonazepam intramuscular administration in the treatment of agitation symptoms in Chinese patients with schizophrenia: A network meta-analysis. Gen Psychiatr. 2018; 31(2):e000016. National Library of Medicine. Accessed October 10 2026. Mauri MC, Paletta S, Di Pace C, Reggiori A, Cirnigliaro G, Valli I, Altamura AC. (2018). Clinical Pharmacokinetics of Atypical Antipsychotics: An Update. Clin Pharmacokinet. 2018 Dec;57(12):1493-1528. PubMed. Accessed October 10 2026. Sedhai YR, Atreya A, Phuyal P, Basnyat S, Pokhrel S. (1000). Case Report: Ziprasidone induced neuroleptic malignant syndrome. F1000Res. 2021; 10:124. National Library of Medicine. Accessed October 10 2026. Macaluso M, Preskorn SH. (2018). Knowledge of the pharmacology of antidepressants and antipsychotics yields results comparable with pharmacogenetic testing. J Psychiatr Pract. 2018 Nov; 24(6):416-419. PubMed. Accessed October 10 2026. Scheen AJ, De Hert M. (2005). [Drug-induced diabetes mellitus: the example of atypical antipsychotics]. Rev Med Liege. 2005 May-Jun; 60(5-6):455-60. PubMed. Aronow WS, Shamliyan TA. (2018). Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders. Ann Transl Med. 2018 Apr; 6(8):147. National Library of Medicine. Accessed October 10 2026. Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW, Azorin JM, Yatham L, Mosolov S, Möller HJ, Kasper S., Members of the WFSBP task force on bipolar affective disorders working on this topic. (2018). The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder. World J Biol Psychiatry. 2018 Feb; 19(1):2-58. PubMed. Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P., Danish Psychiatric Society. (2015). Danish Society of Obstetrics and Gynecology. Danish Paediatric Society. Danish Society of Clinical Pharmacology. Use of psychotropic drugs during pregnancy and breast-feeding. Acta Psychiatr Scand Suppl. 2015;(445):1-28. PubMed. Pfizer U.S. Pharmaceuticals Group. (2001). Geodon (ziprasidone): Product information. labeling.pfizer.com. Accessed October 10 2026. Medical Content The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy. About MentalHealth.com MentalHealth.com helps people understand themselves, build healthier relationships, and access the right care. We bring together mental health education, diagnostics, and care management to support well-being throughout every phase of life. Author Cristina Po Wenger Writer Cristina Po Wenger is a medical writer and mental health advocate with a Sociology Degree from the University of Stirling. Published November 22, 2022 Updated August 13, 2025 Medical Reviewer Amy Shelby, M.S. M.S. Counseling Psychology Amy Shelby is a medical reviewer with a B.A. in Psychology from Northwestern and an M.S. in Psychology from Chatham University. Reviewed November 23, 2022 Related community Medications Explore questions and perspectives about psychiatric medications and the treatment experience. Table of contentsChoose a section Ziprasidone brand names What is ziprasidone prescribed for? How does ziprasidone work? How is ziprasidone usually taken? How long does ziprasidone stay in your system? 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PubMed.","links":[{"url":"https://pubmed.ncbi.nlm.nih.gov/16035311/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-ziprasidone-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"PubMed"}],"url":"https://pubmed.ncbi.nlm.nih.gov/16035311/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-ziprasidone-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":9,"id":"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#effects-atypical-antipsychotic-drugs-qt-interval-patients-mental-disorders","text":"Aronow WS, Shamliyan TA. (2018). Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders. Ann Transl Med. 2018 Apr; 6(8):147. National Library of Medicine. 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The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Acute and long-term treatment of mixed states in bipolar disorder. World J Biol Psychiatry. 2018 Feb; 19(1):2-58. PubMed.","links":[{"url":"https://pubmed.ncbi.nlm.nih.gov/29098925/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-ziprasidone-uses-dosage-side-effects&utm_source=mentalhealth.com","label":"PubMed"}],"url":"https://pubmed.ncbi.nlm.nih.gov/29098925/?utm_medium=referral&utm_campaign=libra&utm_content=external_resource&utm_id=site-library-ziprasidone-uses-dosage-side-effects&utm_source=mentalhealth.com"},{"number":11,"id":"https://www.mentalhealth.com/library/ziprasidone-uses-dosage-side-effects#danish-society-obstetrics-gynecology","text":"Larsen ER, Damkier P, Pedersen LH, Fenger-Gron J, Mikkelsen RL, Nielsen RE, Linde VJ, Knudsen HE, Skaarup L, Videbech P., Danish Psychiatric Society. (2015). 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