23rd Nov 2022
M.S. Counseling Psychology
Amisulpride, often sold under the brand name Solian, is an antipsychotic and anti-nausea medication. It is used intravenously in smaller doses to treat postoperative nausea and vomiting, and orally in larger doses to treat schizophrenia in adults.
There are various brand names for amisulpride, the most prominent of which is Solian.
Other brand names include Amgrace, Amisure, Amisyt, Amplicon, ARIDE, Barhemsys, Bipo-Life, Doxamil, Goldpride, Psyride, Sizopride, Solaze, Sulpitac, Sulpra, Zonapride, and Zulpride.
The primary use of amisulpride is as a first-line treatment for the management of acute psychosis. Adults with schizophrenia are often prone to psychotic episodes, where the patient can, along with hallucinations and delusions (positive symptoms), appear “distressed, not necessarily cooperative, out of touch, and agitated”. The goal of using amisulpride here is to reduce patient distress. It is often associated with the management of agitation and sometimes aggressive behavior.
Another common use of amisulpride is for treating postoperative nausea and vomiting (PONV). After an operation, patients can often feel nauseous and potentially vomit. This can cause distress for patients and can prolong care requirements. If PONV persists after the administration of more conventional first-line anti-nausea prophylaxis, amisulpride has been found to be safe and effective as prophylaxis of postoperative nausea and vomiting when given in combination with an anti-nausea medication from another class.
Studies have also shown that amisulpride can be very effective in the treatment of depression in patients with schizophrenia, in comparison to the more conventional treatment, risperidone.
When used for treating schizophrenia, high doses of amisulpride work by blocking the dopamine D2 and D3 receptors in the brain. These receptors help regulate our locomotion (ability to move), attention, sleep, memory, learning, cognition (perception and understanding), and impulse control. The blocking of these receptors inhibits dopamine production, which in turn reduces the symptoms of psychosis (hallucinations, delusions, agitation, etc.).
When used to treat depression in schizophrenic patients, smaller doses work by blocking the inhibitory receptors in the brain. This helps to increase dopamine production and thus aids with depression and anxiety (negative symptoms of schizophrenia).
When used to treat PONV, amisulpride blocks the signals to the brain that cause nausea and vomiting.
When used to treat schizophrenia, amisulpride is usually taken orally in tablet form. The recommended daily dosage of oral amisulpride is between 400 and 800 milligrams per day.
When used to treat PONV, it is injected intravenously (directly into the veins). The recommended dosage for treating PONV is five to ten milligrams.
After an oral dose, the elimination half-life (the time it takes for the full dosage of a drug to reduce to half within the body) is around 12 hours.
For an intravenous dose, the elimination half-life is four to five hours.
Amisulpride is expelled from the body in the urine.
Like most antipsychotic medications, amisulpride can cause side effects, although the occurrence of side effects is rare. This is why there are few common side effects of the medication and any side effects from the below warrants further medical advice.
You should stop taking amisulpride immediatelyand seek medical attention if you have any of the following side effects:
A doctor should be contacted as soon as possible if any of the following adverse effects are present:
Other side effects include:
Before you take amisulpride, inform your doctor if you:
Before taking amisulpride, you should always inform your doctor or pharmacist if you are taking other medications, including medicines without prescriptions or herbal medicines. Amisulpride can have adverse reactions on the way other medicines work and vice versa.
Tell your doctor if you are taking any of the following:
Do not drink alcohol while taking amisulpride, as it can alter the effect alcohol has on you.
Keep amisulpride in a safe place and out of the reach of children. Do not use it when it has passed its expiration date.
Studies have shown that overdoses of amisulpride can be highly cardiotoxic (harmful to the heart) and can cause various cardiovascular responses, including:
These conditions can all have potentially dangerous complications, and you should therefore seek medical assistance at the earliest opportunity.