Neuroimaging in Psychological Testing
Neuroimaging is revolutionizing how mental health conditions are understood and treated. Once used mainly for detecting brain injuries, it plays a growing role in psychological testing. Neuroimaging by revealing brain activity and structure complements interviews, questionnaires, and other tools to create more accurate mental health profiles. This article explores how neuroimaging enhances psychological testing by offering deeper insight into the brain’s role in conditions like depression and anxiety, ultimately supporting more personalized treatment plans.

What Is Neuroimaging?
Neuroimaging, also known as brain imaging, includes a variety of technologies that allow doctors and scientists to see inside a patient’s head and learn how the brain appears and functions. This is especially helpful in diagnosing mental illness, as neuroimaging can reveal more about the brain and how it affects thoughts, emotions, and actions.
Regular medical tests, like X-rays or blood work, can’t detect mental illnesses such as depression, anxiety, and bipolar disorder. However, neuroimaging shows changes in the brain’s structure or activity that could explain what’s happening. For example, they might see areas that are overactive or not active enough.
The newest neuroimaging tools show how different brain regions connect and communicate, tracking the sequence of events in the brain during specific cognitive processes like reading or remembering [1].
In psychological testing, neuroimaging can:
- Support diagnoses by revealing brain patterns linked to disorders like depression, ADHD, or schizophrenia
- Track treatment response by showing how the brain changes with therapy or medication
- Personalize treatment plans based on a patient’s unique brain function
- Further research, especially in understanding the biological basis of mental health conditions
In simple terms, neuroimaging provides a clearer picture of the brain’s neural activity, helping doctors better understand how it works in healthy people and those with mental health conditions.
Types of Neuroimaging Techniques
Doctors and researchers use several neuroimaging techniques to study the brain. Each method provides different information and has strengths and limitations. Understanding the various neuroimaging techniques and brain scan types gives a fuller picture of how the brain works.
Neuroimaging methods are divided into two main types: structural and functional. Both can complement traditional psychological assessments by providing biological context to behavioral symptoms. Here are the most common neuroimaging techniques used by doctors today:
Structural Imaging Techniques
Structural imaging techniques provide detailed images of the outside or physical structure of the brain, including its shape, size, and any possible damage. They help understand what might be happening if someone has a brain injury or a mental health illness.
Structural imaging techniques include:
Magnetic Resonance Imaging (MRI)
An MRI is one of the more popular methods, using magnets and radio waves to take clear and detailed pictures of the brain. This helps identify conditions such as tumors, strokes, or brain structure changes that could affect how it works. Structural MRIs can also show differences in the brain’s volume and shape in people with conditions like schizophrenia, autism, or major depression.
Computed Tomography (CT) Scan
A CT scan uses X-rays to create detailed, layered images of the brain. Doctors use this in emergencies to quickly evaluate bleeding or brain injuries. However, although this is its primary use, it can sometimes help rule out physical causes of cognitive or behavioral symptoms, too.
Structural imaging techniques examine the brain’s physical features and help with:
- Diagnosing injuries after a fall or accident
- Finding tumors or growths
- Spotting strokes and areas where blood flow to the brain is blocked
- Monitoring brain diseases (like Alzheimer’s disease), where there are changes over time
- Planning surgeries with detailed anatomy information
In psychological testing, structural imaging scans can help rule out neurological causes of behavioral symptoms, identify brain atrophy in dementia-related conditions, or examine developmental disorders affecting brain anatomy.
While structural imaging doesn’t show how the brain works (like functional imaging does), it’s vital to understand the brain’s physical conditions. It offers a clear view of what’s happening inside the brain and can guide treatment options.
Functional Imaging Techniques
Doctors use functional imaging techniques to see how the brain works in real time, highlighting which parts are more active during specific tasks and at rest. These help doctors understand how different areas of the brain function and are used to study mental health conditions or brain injuries.
The most common functional imaging techniques are:
Functional Magnetic Resonance Imaging (fMRI)
The role of fMRI is to reveal which parts of the brain are working by tracking blood flow and circulation. When an area of the brain works harder, it receives more blood. This helps doctors understand brain activity during thinking, feeling, or moving and is used to examine memory issues, depression, and healing after injury.
Positron Emission Tomography (PET)
PET scans use a small amount of radioactive dye to examine how the brain uses energy. They show where the brain is and isn’t active, identifying problems like Alzheimer’s or epilepsy. PET scans are also helpful in researching how different treatments affect the brain. At the same time, they can also be used to help clinicians understand chemical changes in the brain, such as reduced serotonin activity in people with depression.
Electroencephalography (EEG)
EEGs test the electrical activity in the brain and identify any unusual activity. They help identify seizures, sleep disorders (like apnea), neurological disorders, and other conditions, such as tumors, infections, and strokes.
Functional imaging techniques are powerful tools for understanding the brain. They give doctors a peek into the brain’s workings, helping them diagnose and treat conditions more effectively.
EEGs are used for:
- Studying brain activity to see which parts of the brain are active
- Diagnosing various mental health issues, like depression or anxiety
- Researching treatments to show how the brain responds to medications and therapies
- Monitoring brain recovery
- Detecting diseases like Alzheimer’s disease or epilepsy
How Is Neuroimaging Used in Testing?
Psychological testing traditionally includes assessments like interviews, self-report questionnaires, and standardized tasks that evaluate thinking, behavior, and emotions. Neuroimaging doesn’t replace these methods, but provides another layer of understanding.
Neuroimaging can be used in a variety of ways in the context of psychological testing, including [2]:
- When Traditional Assessments are Inconclusive: Neuroimaging can help clarify whether symptoms have a neurological basis.
- For Treatment-Resistant Cases: Neuroimaging might uncover biological patterns that point to a different diagnosis or treatment approach if someone doesn’t respond to therapy or medication.
- In Research Settings: Neuroimaging helps validate psychological tests by correlating scores with brain activity.
- To Personalize Care: For example, someone with depression might show a unique brain activation pattern that responds better to one type of therapy over another.
During a neuroimaging test, patients lie still in a machine like an MRI or CT scanner, which takes detailed pictures of the brain. The painless tests yield results that give doctors essential information, aiding in accurate diagnoses and effective treatments.
Limitations of Neuroimaging in Psychological Testing
Though powerful, neuroimaging has limitations regarding psychological testing and mental health assessments. One of the most important things to remember is that neuroimaging isn’t always precise. The scans reveal changes or unusual activity in the brain, but fail to explain why those changes occur or what they mean.
Additional limitations of neuroimaging include:
- Provides an Incomplete Picture: Neuroimaging doesn’t show or measure neuropsychological activities, like emotions, thoughts, and behaviors. While scans reveal parts of the brain that are active during mental processes, they don’t give the complete picture of someone’s inner experience or how they think and feel. They should always be interpreted alongside behavioral assessments.
- Cost and Access: Advanced medical tests, such as neuroimaging, are expensive and not always available to those who could benefit from them. This makes it harder for some people to get the necessary brain scans.
- Difficult to Interpret: Even when the scans are complete, they are complex and challenging to interpret. Doctors may have differing views on what the scans show and how they relate to different mental health conditions and illnesses.
It’s also important to note that neuroimaging isn’t always necessary for diagnosing and treating mental health issues. Doctors can make accurate assessments without needing to order brain scans. Medical guideline recommendations support using brain scans only for specific reasons and if the results will impact diagnosis and treatment decisions [3][4].
Conclusion
Neuroimaging plays an increasingly important role in psychological testing by helping to link the biology of the brain with thoughts, emotions, and behaviors. From revealing structural changes linked to cognitive decline to showing real-time activity related to emotion or memory, these tools help paint a fuller picture of mental health.However, neuroimaging is just one piece of the puzzle that helps us understand the brain and mental health. Ultimately, it works best when combined with other assessments and evaluations, helping to get the complete picture of someone’s overall well-being, so that doctors can provide a more personalized, effective mental health care.
- American Psychological Association. (2014). Scanning the brain. American Psychological Association. https://www.apa.org/topics/neuropsychology/brain-form-function. Accessed June 4 2025.
- XUE, G., CHEN, C., LU, Z.-L., & DONG, Q. (2010). Brain Imaging Techniques and Their Applications in Decision-Making Research. Acta Psychologica Sinica, 42(1), 120–137. https://pmc.ncbi.nlm.nih.gov/articles/PMC2849100/. Accessed June 4 2025.
- Tamangani J. (2016). Neuroimaging. Australian family physician, 45(11), 788–792. Retrieved from https://pubmed.ncbi.nlm.nih.gov/27806446/. Accessed June 4 2025.
- Buethe, J., Nazarian, J., Kalisz, K., & Wintermark, M. (2016). Neuroimaging Wisely. AJNR. American journal of neuroradiology, 37(12), 2182–2188. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC7963871/. Accessed June 4 2025.
The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.
MentalHealth.com is a health technology company guiding people towards self-understanding and connection. The platform provides reliable resources, accessible services, and nurturing communities. Its purpose is to educate, support, and empower people in their pursuit of well-being.
Erin L. George, MFT, holds a master's degree in family therapy with a focus on group dynamics in high-risk families. As a court-appointed special advocate for children, she is dedicated to helping families rebuild relationships and improve their mental and behavioral health.
Jennie Stanford, M.D., is a dual board-certified physician with nearly ten years of clinical experience in traditional practice.
The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.
MentalHealth.com is a health technology company guiding people towards self-understanding and connection. The platform provides reliable resources, accessible services, and nurturing communities. Its purpose is to educate, support, and empower people in their pursuit of well-being.