How effective is Prozac for OCD?
Jesse Hanson, Ph.D.
– Written by
Allan Schwartz, Ph.D.
– Updated on September 7, 2025
Question
I have a question. I am new to this site. I had been on Prozac for about 9 years and it was wonderful. It almost totally alleviated all of my OCD symptoms. Well, I was incredibly stupid and thought I no longer needed medication and weaned off of Prozac last October. Needless to say, my OCD came back full force (worse this time around) in March of this year.
I honestly thought I was going to die. Well, after a try on Lexapro which made me tired and more depressed I went back on Prozac. I started on 20 mg eight weeks ago, went up to 40 mg six weeks ago, and now have been on 60 mg for 2 1/2 weeks. The last time I was on Prozac 40 mg the entire time. Well, I am really scared.
Sometimes I feel like I am feeling better and at other times I feel awful. I know increasing the dose brings increased anxiety, etc., but should I wait with the 60 mg for an extended period of time or do you think Prozac is not working for me this time???? I want this to work again so badly. I know the meds work because it worked for 9 years. I also know I can feel better because I did feel great. Please help me!!!!!!
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Answer
First, let me try to help you by reassuring you that you will get your symptoms under control once again. OCD is an anxiety disorder and you are reacting to this medication issue with great anxiety. So, take a deep breath, relax and think of pleasant things that you really enjoy. More about that later.
Nine years is a long time to be on one anti depressant. It is common for any one anti depressant to stop working as effectively after a few years. Lexapro is an excellent medication but it may it was not right for your particular symptoms and that is not unusual. There are other anti depressants that are very helpful with OCD and one of them is Zoloft.
Chemically, it is similar to Prozac and would not be a giant leap in terms of the type of medicine your body is used to. Zoloft has even been approved by the FDA for the treatment of OCD. Another excellent medication is Paxil and you can be assured that it too will help OCD. Given your level of anxiety at this time, I would recommend Zoloft because you now know that it is approved by the FDA. Psychology plays a big roll in all of this.
My sincere hope is that you are under the care of a psychiatrist. While your family physician is fully capable of prescribing these medications, the psychiatrists are the specialists and experts in this area.
What I want to especially emphasize to you is the need for psychotherapy to be part of the total treatment process. It seems that you had nine years of Prozac, and that was fine, but you evidently did not have the opportunity to engage in Cognitive-Behavioral Therapy (CBT). The value of CBT is to help you to learn to control these symptoms with or without medication.
All the research findings are that a combination of CBT and medication work best and that, in some circumstances, CBT alone works well. However, I believe you are too anxious at this point to have CBT without medication. Therefore, you need a referral to a therapist who knows CBT and will use it (with your medication) to help you learn about OCD and how to stop it.
To return to what I mentioned earlier in this posting, you need to learn relaxation techniques, along with treatment, to help you reduce anxiety. Deep body relaxation, deep breathing and meditation are excellent ways to reduce stress and anxiety. There are classes given at local community centers and colleges for the public to learn to use these techniques.
There are no magic pills. That is why you must learn to do more than rely on medication alone to deal with OCD.
Best of Luck.
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Jesse Hanson, Ph.D., is a somatic psychologist with more than 20 years of experience in clinical psychology and neuropsychology.
Allan Schwartz, LCSW, Ph.D. is a medical writer with more than 30 years of clinical experience as a Licensed Clinical Social Worker. He writes on a wide range of mental health topics, including mood and anxiety disorders, eating disorders, trauma, abuse, stress, and relationship challenges.
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Jesse Hanson, Ph.D.
– Written by
Allan Schwartz, Ph.D.
– Updated on September 7, 2025
Additional Reading
The Clinical Affairs Team at MentalHealth.com is a dedicated group of medical professionals with diverse and extensive clinical experience. They actively contribute to the development of content, products, and services, and meticulously review all medical material before publication to ensure accuracy and alignment with current research and conversations in mental health. For more information, please visit the Editorial Policy.
We are a health technology company that guides people toward self-understanding and connection. The platform provides reliable resources, accessible services, and nurturing communities. Its purpose is to educate, support, and empower people in their pursuit of well-being.